Combined Aerobic and Resistance Exercise via videoconferencing for Moderate-severe Chronic Kidney Disease Not Treated With Dialysis

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Moderate-severe Chronic Kidney Disease Not Treated With Dialysis+1 MoreCombined Aerobic and Resistance Exercise via videoconferencing - Behavioral
Eligibility
30 - 75
All Sexes
What conditions do you have?
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Study Summary

This trial is studying how well a combined resistance training and aerobic exercise program works compared to a health education program in improving physical function in people with kidney dysfunction.

Eligible Conditions
  • Moderate-severe Chronic Kidney Disease Not Treated With Dialysis
  • Diabetic Kidney Disease, HbA1c Less Than 8.5

Treatment Effectiveness

Effectiveness Progress

1 of 3

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dulaglutide injection
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Study Objectives

2 Primary · 21 Secondary · Reporting Duration: 12 weeks

12 weeks
Change in Systemic oxidative stress (markers of arachidonic acid peroxidation)
Change in aerobic capacity (VO2max) (ml/kg/min)
Change in muscle fatigue
Change in physical performance
Connor-Davidson Resilience Scale 25 (CD-RISC-25)
FACIT fatigue scale (Version 4)
Health Questionnaire
Kidney Diseases
Lubben Social Network Scale
Indium
MoCA test (cognitive testing)
Monocyte bioenergetics
Muscle mitochondrial oxidative phosphorylation capacity.
Muscle mitochondrial reactive oxygen species production from muscle tissue.
Muscle mitochondrial reactive oxygen species production from permeabilized muscle fibers.
Perceived Stress (NIH)
Physical Activity Questionnaire (HAP)
Pittsburgh Fatigability Scale
Quadriceps muscle work efficiency
Self-Efficacy for Managing Chronic Conditions (PROMIS Bank)
Self-reported fatigue (NIH PROMIS Fatigue)
Self-reported physical function (PROMIS mobility)
Total work
Walking economy during 6 minute walk

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

2
US-APR2020
2
dulaglutide injection
2
Exercise Training/Sodium Bicarbonate

Trial Design

2 Treatment Groups

Usual Care
1 of 2
Combined Aerobic and Resistance Exercise
1 of 2

Active Control

Experimental Treatment

45 Total Participants · 2 Treatment Groups

Primary Treatment: Combined Aerobic and Resistance Exercise via videoconferencing · No Placebo Group · Phase 2

Combined Aerobic and Resistance Exercise
Behavioral
Experimental Group · 1 Intervention: Combined Aerobic and Resistance Exercise via videoconferencing · Intervention Types: Behavioral
Usual CareNoIntervention Group · 1 Intervention: Usual Care · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks

Who is running the clinical trial?

University of California, DavisLead Sponsor
843 Previous Clinical Trials
5,012,306 Total Patients Enrolled
Baback Roshanravan, MD MS MSPHPrincipal InvestigatorUC Davis
Javier Lopez, MDPrincipal InvestigatorUC Davis Department of Medicine/Division of Cardiology
1 Previous Clinical Trials
225 Total Patients Enrolled

Eligibility Criteria

Age 30 - 75 · All Participants · 7 Total Inclusion Criteria

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References

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