Cardizem La

Angina Pectoris, Variant, Atrial Fibrillation, Proteinuria + 11 more
Treatment
6 FDA approvals
20 Active Studies for Cardizem La

What is Cardizem La

DiltiazemThe Generic name of this drug
Treatment SummaryDiltiazem is a drug used to lower blood pressure and treat certain heart conditions. It belongs to a class of drugs called calcium channel blockers and works by preventing calcium from entering the heart and blood vessels, which relaxes the muscles and lowers the pressure. Diltiazem is available in both an oral and intravenous form and is sold under the brand names Cardizem and Tiazac. It is commonly used to treat high blood pressure, irregular heartbeats, and chest pain. It can also be used to treat anal fissures, migraines, pulmonary hypertension, and rest-related cramps.
Cardizemis the brand name
Cardizem La Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656

Approved as Treatment by the FDA

Diltiazem, commonly known as Cardizem, is approved by the FDA for 6 uses which include Coronary Vasospasm and Coronary Artery Vasospasm .
Coronary Vasospasm
Helps manage Coronary Artery Vasospasm
Coronary Artery Vasospasm
Helps manage Coronary Artery Vasospasm
Anginal Pain
Helps manage Anginal Pain
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Angina Pectoris
Helps manage Anginal Pain

Effectiveness

How Cardizem La Affects PatientsDiltiazem is a medication that lowers blood pressure and relaxes the blood vessels. It does this by blocking calcium from entering the muscle cells of the heart and blood vessels. By doing this, it helps reduce the risk of stroke and heart attack. In studies, taking diltiazem was found to lower the diastolic blood pressure by up to 8.6 mmHg in people with high blood pressure, and improved exercise tolerance in those with chronic stable angina. It has also been suggested that diltiazem may provide a protective effect against stroke in those with hypertension.
How Cardizem La works in the bodyDiltiazem works by blocking calcium from entering the cells in the heart and blood vessels. This reduces the amount of calcium available in the cells and allows the muscles to relax. As a result, blood pressure decreases, oxygen delivery to the heart increases, and the heart's workload is reduced. This leads to improved exercise tolerance and improved heart health.

When to interrupt dosage

The advocated measure of Cardizem La is dependent upon the diagnosed illness, including prophylaxis of migraine headaches, Fissure;Anal and Anginal Pain. The amount of dosage fluctuates as per the delivery approach noted in the table beneath.
Condition
Dosage
Administration
Muscle Cramp
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris, Variant
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Migraine Disorders
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina, Stable
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Cardiomyopathy, Dilated
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Atrial Fibrillation
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Hypertensive disease
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Fissure in Ano
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Tachycardia, Supraventricular
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Proteinuria
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Diabetic Neuropathy
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Hypertension
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Coronary Vasospasm
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Warnings

Cardizem La has ten contraindications, thus should not be utilized when encountering any of the conditions in the following table.Cardizem La Contraindications
Condition
Risk Level
Notes
Heart Attack
Do Not Combine
accessory bypass tract
Do Not Combine
accessory bypass tract
Do Not Combine
Bradycardia
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulmonary Congestion
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Hypotension
Do Not Combine
There are 20 known major drug interactions with Cardizem La.
Common Cardizem La Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Cardizem La Toxicity & Overdose RiskDiltiazem is toxic when taken in large doses. The toxic dose in mice is between 415-740mg/kg, in rats between 560-810mg/kg and in dogs over 50 mg/kg. In monkeys, a dose of 360 mg/kg was fatal. Reports of diltiazem overdose range from less than 1g to 18g. Symptoms include slowed heart rate, low blood pressure, heart blockage, and heart failure which can lead to dizziness, fatigue, and lightheadedness. Treatment includes administering atropine, isoproterenol, or cardiac pacing to treat bradycardia or
image of a doctor in a lab doing drug, clinical research

Cardizem La Novel Uses: Which Conditions Have a Clinical Trial Featuring Cardizem La?

Currently, there are 228 active trials investigating the potential of Cardizem La to alleviate Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Pulmonary Hypertension
30 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Early Phase 1
Tachycardia, Supraventricular
2 Actively Recruiting
Phase 3, Phase 2
Angina, Stable
1 Actively Recruiting
Not Applicable
Diabetic Neuropathy
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Angina Pectoris, Variant
0 Actively Recruiting
Angina Pectoris
2 Actively Recruiting
Not Applicable, Phase 4
Cardiomyopathy, Dilated
0 Actively Recruiting
Proteinuria
3 Actively Recruiting
Phase 2, Phase 3
Muscle Cramp
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Vasospasm
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Fissure in Ano
0 Actively Recruiting

Cardizem La Reviews: What are patients saying about Cardizem La?

5Patient Review
12/4/2008
Cardizem La for High Blood Pressure
5Patient Review
8/11/2010
Cardizem La for High Blood Pressure
my husband is taking it for hypertension. He's allergic to sulfa, which rules out most blood pressure medications. Lisinopril 20mg isn't doing the trick either; his blood pressure is still high.
4.3Patient Review
9/6/2008
Cardizem La for Ventricular Rate Control in Atrial Fibrillation
4.3Patient Review
1/15/2009
Cardizem La for High Blood Pressure
I was prescribed this after I couldn't tolerate metoprolol and bystolic. In the two weeks since I started taking cardizem, I've developed pain in my neck and shoulder on the right side. It's getting worse every day and I have no idea why.
3.7Patient Review
11/5/2008
Cardizem La for High Blood Pressure
View All Reviews
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Patient Q&A Section about cardizem la

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Cardizem LA stand for?

"Generic diltiazem hydrochloride is a calcium channel blocker used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders."

Answered by AI

What is the difference between Cardizem CD and LA?

"Unlike other diltiazem formulations that are taken once a day, CARDIZEM® LA is a tablet formulation. Its pharmacokinetic profile differs from that of CARDIZEM® CD, another extended-release formulation of diltiazem, in that it has a smoother drug-release profile with a "one-peak" plasma concentration time curve."

Answered by AI

Is Cardizem LA long acting?

"Make sure to tell all of your health care providers that you take Cardizem LA (diltiazem long-acting tablets). This includes your doctors, nurses, pharmacists, and dentists. Avoid driving or doing other tasks that require you to be alert until you see how Cardizem LA (diltiazem long-acting tablets) affects you."

Answered by AI

Is diltiazem ER the same as Cardizem LA?

"Diltiazem is a medication used to treat high blood pressure and chest pain by relaxing blood vessels and decreasing the workload of the heart. It is part of a group of medications known as calcium channel blockers."

Answered by AI

Clinical Trials for Cardizem La

Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
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