Cardizem La

Paroxysmal Supraventricular Tachycardia (PSVT), Pulmonary Hypertension, Coronary Artery Spasm + 12 more
Treatment
4 FDA approvals
20 Active Studies for Cardizem La

What is Cardizem La

DiltiazemThe Generic name of this drug
Treatment SummaryDiltiazem is a drug used to lower blood pressure and treat certain heart conditions. It belongs to a class of drugs called calcium channel blockers and works by preventing calcium from entering the heart and blood vessels, which relaxes the muscles and lowers the pressure. Diltiazem is available in both an oral and intravenous form and is sold under the brand names Cardizem and Tiazac. It is commonly used to treat high blood pressure, irregular heartbeats, and chest pain. It can also be used to treat anal fissures, migraines, pulmonary hypertension, and rest-related cramps.
Cardizemis the brand name
Cardizem La Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656

Approved as Treatment by the FDA

Diltiazem, commonly known as Cardizem, is approved by the FDA for 4 uses which include Hypertensive disease and Coronary Artery Vasospasm .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Coronary Artery Vasospasm
Helps manage Coronary Artery Vasospasm
Anginal Pain
Helps manage Anginal Pain
Chronic Stable Angina Pectoris
Helps manage Chronic Stable Angina Pectoris

Effectiveness

How Cardizem La Affects PatientsDiltiazem is a medication that lowers blood pressure and relaxes the blood vessels. It does this by blocking calcium from entering the muscle cells of the heart and blood vessels. By doing this, it helps reduce the risk of stroke and heart attack. In studies, taking diltiazem was found to lower the diastolic blood pressure by up to 8.6 mmHg in people with high blood pressure, and improved exercise tolerance in those with chronic stable angina. It has also been suggested that diltiazem may provide a protective effect against stroke in those with hypertension.
How Cardizem La works in the bodyDiltiazem works by blocking calcium from entering the cells in the heart and blood vessels. This reduces the amount of calcium available in the cells and allows the muscles to relax. As a result, blood pressure decreases, oxygen delivery to the heart increases, and the heart's workload is reduced. This leads to improved exercise tolerance and improved heart health.

When to interrupt dosage

The advocated measure of Cardizem La is dependent upon the diagnosed illness, including prophylaxis of migraine headaches, Fissure;Anal and Anginal Pain. The amount of dosage fluctuates as per the delivery approach noted in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Chronic Stable Angina Pectoris
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Anginal Pain
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Proteinuria
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Pulmonary Hypertension
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Coronary Artery Spasm
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
prophylaxis of migraine headaches
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Diabetic Neuropathy
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Fissure;Anal
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Dilated Cardiomyopathies, Idiopathic
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Atrial Fibrillation
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Angina Pectoris, Variant
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Paroxysmal Supraventricular Tachycardia (PSVT)
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
Flutter, Atrial
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous
leg cramps
120.0 mg, 180.0 mg, , 90.0 mg, 300.0 mg, 240.0 mg, 360.0 mg, 30.0 mg, 420.0 mg, 5.0 mg/mL, 60.0 mg, 100.0 mg, 0.83 mg/mL, 1.0 mg/mL
, Capsule, extended release, Tablet, extended release - Oral, Capsule - Oral, Solution - Intravenous, Tablet, extended release, Injection, solution, Tablet, Capsule, extended release - Oral, Oral, Tablet, coated - Oral, Capsule, Liquid, Tablet, film coated - Oral, Solution, Tablet - Oral, Tablet, coated, Capsule, coated, extended release - Oral, Injection, solution - Intravenous, Intravenous, Capsule, coated, extended release, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Tablet, film coated, Injection - Intravenous, Injection, Powder, for solution - Intravenous

Warnings

Cardizem La has ten contraindications, thus should not be utilized when encountering any of the conditions in the following table.Cardizem La Contraindications
Condition
Risk Level
Notes
Heart Attack
Do Not Combine
Hypotension
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Atrial Fibrillation
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
sinus shock syndrome
Do Not Combine
Pulmonary Congestion
Do Not Combine
accessory bypass tract
Do Not Combine
There are 20 known major drug interactions with Cardizem La.
Common Cardizem La Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Cardizem La Toxicity & Overdose RiskDiltiazem is toxic when taken in large doses. The toxic dose in mice is between 415-740mg/kg, in rats between 560-810mg/kg and in dogs over 50 mg/kg. In monkeys, a dose of 360 mg/kg was fatal. Reports of diltiazem overdose range from less than 1g to 18g. Symptoms include slowed heart rate, low blood pressure, heart blockage, and heart failure which can lead to dizziness, fatigue, and lightheadedness. Treatment includes administering atropine, isoproterenol, or cardiac pacing to treat bradycardia or
image of a doctor in a lab doing drug, clinical research

Cardizem La Novel Uses: Which Conditions Have a Clinical Trial Featuring Cardizem La?

Currently, there are 228 active trials investigating the potential of Cardizem La to alleviate Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
Pulmonary Hypertension
19 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Phase 1, Phase 4, Not Applicable
Proteinuria
4 Actively Recruiting
Phase 2, Phase 3, Phase 4
Anginal Pain
2 Actively Recruiting
Not Applicable, Phase 4
Atrial Fibrillation
163 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Diabetic Neuropathy
24 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
Flutter, Atrial
0 Actively Recruiting
Fissure;Anal
0 Actively Recruiting
Chronic Stable Angina Pectoris
2 Actively Recruiting
Not Applicable
Angina Pectoris, Variant
0 Actively Recruiting
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4
Coronary Artery Spasm
0 Actively Recruiting
Paroxysmal Supraventricular Tachycardia (PSVT)
1 Actively Recruiting
Phase 3
prophylaxis of migraine headaches
0 Actively Recruiting
Dilated Cardiomyopathies, Idiopathic
0 Actively Recruiting
leg cramps
0 Actively Recruiting

Cardizem La Reviews: What are patients saying about Cardizem La?

5Patient Review
12/4/2008
Cardizem La for High Blood Pressure
5Patient Review
8/11/2010
Cardizem La for High Blood Pressure
my husband is taking it for hypertension. He's allergic to sulfa, which rules out most blood pressure medications. Lisinopril 20mg isn't doing the trick either; his blood pressure is still high.
4.3Patient Review
9/6/2008
Cardizem La for Ventricular Rate Control in Atrial Fibrillation
4.3Patient Review
1/15/2009
Cardizem La for High Blood Pressure
I was prescribed this after I couldn't tolerate metoprolol and bystolic. In the two weeks since I started taking cardizem, I've developed pain in my neck and shoulder on the right side. It's getting worse every day and I have no idea why.
3.7Patient Review
11/5/2008
Cardizem La for High Blood Pressure
3.7Patient Review
1/9/2010
Cardizem La for Hypertrophic Cardiomyopathy
This medication got my heart arrhythmia under control quickly. However, after a few months of taking it, the afib has come back and now my blood pressure is very low. I'm going to have to talk to my doctor again about this.
3.7Patient Review
11/26/2011
Cardizem La for High Blood Pressure
My son takes this for spasms in his esophagus- it relaxes the muscles there so that food can pass through. He has to take it at bedtime because it makes him dizzy, but it works really well!
3Patient Review
12/28/2008
Cardizem La for Ventricular Rate Control in Atrial Fibrillation
This medication works well for me, as long as I take it before bed. If I miss a day, I experience some pretty intense side effects like rapid heart palpitations and chest pain. So, while it's great for high blood pressure, just be aware that you need to be very consistent with taking it.
2.3Patient Review
3/14/2009
Cardizem La for High Blood Pressure
I started taking this medication a month ago and last night I started to experience a rash on my legs that has been extremely itchy and swollen.
1Patient Review
2/13/2008
Cardizem La for High Blood Pressure
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cardizem la

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Cardizem LA stand for?

"Generic diltiazem hydrochloride is a calcium channel blocker used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders."

Answered by AI

What is the difference between Cardizem CD and LA?

"Unlike other diltiazem formulations that are taken once a day, CARDIZEM® LA is a tablet formulation. Its pharmacokinetic profile differs from that of CARDIZEM® CD, another extended-release formulation of diltiazem, in that it has a smoother drug-release profile with a "one-peak" plasma concentration time curve."

Answered by AI

Is Cardizem LA long acting?

"Make sure to tell all of your health care providers that you take Cardizem LA (diltiazem long-acting tablets). This includes your doctors, nurses, pharmacists, and dentists. Avoid driving or doing other tasks that require you to be alert until you see how Cardizem LA (diltiazem long-acting tablets) affects you."

Answered by AI

Is diltiazem ER the same as Cardizem LA?

"Diltiazem is a medication used to treat high blood pressure and chest pain by relaxing blood vessels and decreasing the workload of the heart. It is part of a group of medications known as calcium channel blockers."

Answered by AI

Clinical Trials for Cardizem La

Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
Have you considered Cardizem La clinical trials? We made a collection of clinical trials featuring Cardizem La, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top