Byetta

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Byetta

What is Byetta

ExenatideThe Generic name of this drug
Treatment SummaryExenatide is a medication that helps to regulate blood sugar levels in patients with diabetes. It works by stimulating the GLP-1 receptor, which causes the pancreas to release insulin and reduces the production of glucagon. It also slows down the emptying of the stomach, helping to keep blood sugar levels stable. Exenatide was approved by the FDA in 2005.
Byettais the brand name
image of different drug pills on a surface
Byetta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Byetta
Exenatide
2005
10

Effectiveness

How Byetta Affects PatientsExenatide helps your body better regulate its response to glucose. It signals your body to release more insulin and less glucagon when glucose is present, except in cases where you have low blood sugar, when a normal amount of glucagon is released. Exenatide also slows down the rate your stomach empties its contents, which helps regulate blood sugar and prevents both low and high blood sugar.
How Byetta works in the bodyExenatide activates a receptor in the body that helps balance levels of insulin and glucagon. This helps to keep blood sugar levels stable and prevents both high and low blood sugar. Exenatide also works to slow down the rate at which food leaves the stomach and decreases appetite, making it easier to maintain healthy blood sugar levels.

When to interrupt dosage

The dose of Byetta is contingent upon the pinpointed condition. The amount of dosage fluctuates, based on the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Physical Activity
, 0.25 mg/mL, 0.005 mg, 0.01 mg, 2.0 mg, 20.0 mg/mL, 2.0 mg/dose, 0.005 mg/pump actuation, 0.01 mg/pump actuation
, Subcutaneous, Injection, Injection - Subcutaneous, Kit, Injection, solution, Injection, solution - Subcutaneous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Subcutaneous, Solution, Solution - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Subcutaneous, Injection, suspension, extended release, Injection, suspension, extended release - Subcutaneous, Suspension, extended release, Suspension, extended release - Subcutaneous
Type 2 Diabetes
, 0.25 mg/mL, 0.005 mg, 0.01 mg, 2.0 mg, 20.0 mg/mL, 2.0 mg/dose, 0.005 mg/pump actuation, 0.01 mg/pump actuation
, Subcutaneous, Injection, Injection - Subcutaneous, Kit, Injection, solution, Injection, solution - Subcutaneous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Subcutaneous, Solution, Solution - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Subcutaneous, Injection, suspension, extended release, Injection, suspension, extended release - Subcutaneous, Suspension, extended release, Suspension, extended release - Subcutaneous
Diet
, 0.25 mg/mL, 0.005 mg, 0.01 mg, 2.0 mg, 20.0 mg/mL, 2.0 mg/dose, 0.005 mg/pump actuation, 0.01 mg/pump actuation
, Subcutaneous, Injection, Injection - Subcutaneous, Kit, Injection, solution, Injection, solution - Subcutaneous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Subcutaneous, Solution, Solution - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Subcutaneous, Injection, suspension, extended release, Injection, suspension, extended release - Subcutaneous, Suspension, extended release, Suspension, extended release - Subcutaneous

Warnings

Byetta has six contraindications. The utilization of Byetta should be avoided if you are afflicted with any of the conditions presented in the below table.Byetta Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Exenatide may interact with Pulse Frequency
There are 20 known major drug interactions with Byetta.
Common Byetta Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Moderate
Exenatide can cause an increase in the absorption of (R)-warfarin resulting in an increased serum concentration and potentially a worsening of adverse effects.
(S)-Warfarin
Moderate
Exenatide can cause an increase in the absorption of (S)-Warfarin resulting in an increased serum concentration and potentially a worsening of adverse effects.
2,4-thiazolidinedione
Moderate
The risk or severity of hypoglycemia can be increased when Exenatide is combined with 2,4-thiazolidinedione.
4-hydroxycoumarin
Moderate
Exenatide can cause an increase in the absorption of 4-hydroxycoumarin resulting in an increased serum concentration and potentially a worsening of adverse effects.
AICA ribonucleotide
Moderate
The risk or severity of hypoglycemia can be increased when Exenatide is combined with AICA ribonucleotide.
Byetta Toxicity & Overdose RiskAnimal studies have linked exenatide to deformities in fetal ribs and vertebrae and slower growth. High blood sugar levels during pregnancy can increase the risk of miscarriage. Exenatide should only be used during pregnancy if the benefits to mother and baby outweigh the risks. In mice, exenatide is found in breast milk, but the effects on breastfed babies is unknown. No data is available on the use of exenatide in children or elderly patients, though caution should be taken when prescribing to the elderly due to their increased risk of side effects. Patients with creatinine clearance of 50mL/min or
image of a doctor in a lab doing drug, clinical research

Byetta Novel Uses: Which Conditions Have a Clinical Trial Featuring Byetta?

162 active studies are presently assessing Byetta's capacity to mitigate symptoms associated with Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
165 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
24 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Byetta Reviews: What are patients saying about Byetta?

5Patient Review
3/31/2015
Byetta for Additional Medication for Diabetes Type 2
Byetta completely stopped my kidney stones from forming.
5Patient Review
5/16/2017
Byetta for Type 2 Diabetes Mellitus
This drug made me so incredibly sick- to the point where I was vomiting uncontrollably and lost a significant amount of hair. I also couldn't sleep because I was so jittery. Needless to say, I will never take this again.
5Patient Review
5/17/2013
Byetta for Type 2 Diabetes Mellitus
The sharp pains in my stomach kept me up at night, to the point where my husband was getting frustrated. Thankfully, this treatment only took a month.
5Patient Review
1/9/2014
Byetta for Additional Medication for Diabetes Type 2
I'm really pleased with how Byetta has worked for me. Not only have my lab results improved, but I've also lost a significant amount of weight as a result of reduced appetite.
5Patient Review
11/23/2012
Byetta for Additional Medication for Diabetes Type 2
Byetta worked to decrease my need for insulin, but unfortunately also gave me such bad indigestion that I had to discontinue use.
4.3Patient Review
2/16/2016
Byetta for Additional Medication for Diabetes Type 2
This drug is effective at curbing your appetite and helping you to avoid overeating. However, it does cause stomach cramps which can be quite uncomfortable. Make sure you're near a bathroom when you take this medication!
4.3Patient Review
1/1/2013
Byetta for Additional Medication for Diabetes Type 2
I began using Byetta at the start of November and have been pleased with results so far. I've lost seven pounds, but my fasting sugar is still a bit high. I'm sure my doctor will increase the dosage when I see him. No bad reactions yet.
4Patient Review
7/19/2014
Byetta for Additional Medication for Diabetes Type 2
I am on my third pen and I am starting to see results now. It really makes me nauseous. ALSO, since I started with Byetta, I have been feeling more depressed. Is this a reported side effect?
4Patient Review
11/22/2012
Byetta for Additional Medication for Diabetes Type 2
3.7Patient Review
12/30/2017
Byetta for Additional Medication for Diabetes Type 2
I've been taking Byetta for a while now and it's helped me keep my A1C at 7.2, which is great.
3.3Patient Review
1/27/2015
Byetta for Type 2 Diabetes Mellitus
This drug has effectively managed my diabetes, and I've even lost weight and brought my A1C down. The only problem is that I can't increase the dosage because it gives me stomach issues. Also, has anyone else experienced chronic bladder infections after taking Byetta for an extended period of time?
3.3Patient Review
6/26/2014
Byetta for Additional Medication for Diabetes Type 2
I only took Byetta for a short while, but I experienced some really severe pain in my stomach and back. It felt like awful gas pressure without any of the benefits of actually passing gas. My doctor told me to stop taking it immediately, which I did. Thankfully, the pain is subsiding as time goes on.
2.7Patient Review
11/8/2015
Byetta for Type 2 Diabetes Mellitus
I'm on day two of the treatment and I haven't felt hungry at all. I had yogurt for breakfast and now I feel like I could vomit. I hope this doesn't last for two weeks like some people have said.
2.3Patient Review
12/9/2018
Byetta for Type 2 Diabetes Mellitus
I tried Byetta for a year, and it didn't help me at all. I'm going to tell my doctor that I'm stopping the medication.
2Patient Review
6/21/2014
Byetta for Type 2 Diabetes Mellitus
I lost all of my hair after starting this treatment. Thankfully, I stopped using it and saw a full reversal in the condition.
1.3Patient Review
2/8/2018
Byetta for Type 2 Diabetes Mellitus
The effect of this medication is excellent; however, the needle is large and difficult to use without drawing blood! It is also longer and bigger than an insulin pen, which makes it more difficult to use without pain.
1Patient Review
3/20/2016
Byetta for Type 2 Diabetes Mellitus
I was really disappointed when my insurance company stopped covering this medication. It did a great job of controlling my Type II diabetes, and the Victoza replacement simply isn't cutting it. I also tried Bydereon, but the needle was painfully large and it left a lump at the injection site.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about byetta

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Byetta still on the market?

"Bydureon is no longer available as of 2018. The two available formulations for exenatide are now Byetta and Bydureon BCise."

Answered by AI

Can Byetta be used for weight loss?

"No, Byetta is not approved for use as a weight-loss drug, however, because Byetta is used along with a healthy diet and exercise program, you may lose weight while using the drug. Additionally, studies show Byetta can cause a loss of appetite. This, too, may lead to weight loss."

Answered by AI

What does Byetta do to the body?

"Byetta lowers blood sugar after eating a meal, between meals, and during fasting periods. It can also help some people lose weight."

Answered by AI

Is Byetta better than metformin?

"Exenatide, sold under the brand name Byetta, is a medication used to treat diabetes mellitus type 2. It is injected subcutaneously twice a day.

Exenatide is used in addition to diet and exercise to lower blood sugar in people with type 2 diabetes. It is usually given together with other diabetes medications, such as metformin.

Exenatide may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation. It may also cause weight loss."

Answered by AI

Clinical Trials for Byetta

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
Image of Medpace Clinical Pharmaology Unit in Cincinnati, United States.

PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
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Estrogen and Testosterone for Gender Differences in Physiology

18 - 40
All Sexes
Kelowna, Canada
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.
Waitlist Available
Has No Placebo
University of British Columbia - OkanaganPhilip Ainslie, PhD
Have you considered Byetta clinical trials? We made a collection of clinical trials featuring Byetta, we think they might fit your search criteria.Go to Trials
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Aerobic Exercise with Blood Flow Restriction for Type 2 Diabetes

19 - 64
All Sexes
Okanagan, Canada
The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.
Waitlist Available
Has No Placebo
Exercise Metabolism and Inflammation Laboratory (+2 Sites)Martin Senechal, PhD
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Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
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Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
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