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What is Azasan
AzathioprineThe Generic name of this drug
Treatment SummaryAzathioprine is a medication used to treat inflammatory conditions like rheumatoid arthritis and to prevent organ rejection in transplant patients. It was first developed in 1956 and was approved by the FDA in 1968. It is a derivative of 6-mercaptopurine, which works to reduce inflammation and suppress the immune system.
Imuranis the brand name
Azasan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Imuran
Azathioprine
1968
50
Approved as Treatment by the FDA
Azathioprine, otherwise called Imuran, is approved by the FDA for 2 uses like Kidney Transplantation and Rheumatoid Arthritis .Kidney Transplantation
Rheumatoid Arthritis
Effectiveness
How Azasan Affects PatientsAzathioprine reduces the activity of the immune system and is taken once a day. It has a narrow range at which it is effective, and patients should be warned of the potential risks of skin cancer and lymphomas.
How Azasan works in the bodyAzathioprine works to control inflammation in the body, but the exact mechanism is not fully understood. It may work by limiting the production of certain molecules, as well as preventing certain types of immune cells from properly functioning. Additionally, one of its metabolites is thought to trigger a chain reaction in cells that leads to cell death.
When to interrupt dosage
The dosage of Azasan is contingent upon the diagnosed condition, such as Atopic Dermatitis, Kidney Transplantation and Crohn's Disease. The measure varies, in accordance with the technique of delivery (e.g. Tablet, film coated - Oral or Injection, powder, lyophilized, for solution - Intravenous) detailed in the table below.Condition
Dosage
Administration
Rheumatoid Arthritis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Kidney Transplantation
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Crohn's Disease
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Uveitis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Multiple Sclerosis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Pericarditis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Psoriasis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Lupus Nephritis
50.0 mg, , 75.0 mg, 100.0 mg, 10.0 mg/mL, 25.0 mg, 100.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Suspension - Oral, Suspension
Warnings
Azasan has two counterindications, and so should not be implemented when encountering any of the conditions in the following table.Azasan ContraindicationsCondition
Risk Level
Notes
Alkylating Agents
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Azathioprine may interact with Pulse Frequency
Common Azasan Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Azathioprine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Azathioprine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Azathioprine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Azathioprine is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Azathioprine is combined with Aldosterone.
Azasan Toxicity & Overdose RiskThe lowest amount of the drug that is toxic to mice is 2500mg/kg, and 400mg/kg for rats. Those who overdose may have symptoms such as decreased production of blood cells, bleeding, and infection, which can be deadly. Treatments for overdose include supportive care and hemodialysis, which can remove up to 45% of the drug from the bloodstream.
Azasan Novel Uses: Which Conditions Have a Clinical Trial Featuring Azasan?
430 active studies are currently being conducted to evaluate the potential of Azasan to mitigate the effects of Rejection; Transplant, Kidney, Uveitis and Crohn's Disease.Condition
Clinical Trials
Trial Phases
Lupus Nephritis
21 Actively Recruiting
Phase 4, Phase 3, Phase 2, Phase 1
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Multiple Sclerosis
194 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Psoriasis
0 Actively Recruiting
Uveitis
15 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Kidney Transplantation
0 Actively Recruiting
Pericarditis
2 Actively Recruiting
Phase 2, Phase 3
Crohn's Disease
35 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Azasan Reviews: What are patients saying about Azasan?
5Patient Review
6/28/2014 This drug has been an absolute godsend. I've tried a lot of different treatments for my condition, and this is by far the most effective one.
5Patient Review
4/24/2010 I had ulcerated colitis for six months and nothing worked to reduce my symptoms. This medication returned me to normal in only a week.
5Patient Review
4/16/2009 I've been taking this medication for two years to help with my ulcerative colitis, in conjunction with prednisone. I worry about the long-term effects of both drugs, but haven't been able to wean myself off the prednisone without experiencing a relapse.
4Patient Review
3/16/2009 This medication has been incredibly effective in keeping my ulcerative colitis under control. I only worry about the long-term effects of taking it.
4Patient Review
10/22/2009 I have had ulcerative colitis for a decade, but this medication has helped me stay in remission for four years now. Although it's not recommended to use during pregnancy, my doctor and I decided that the benefits outweighed the risks in my case and I successfully gave birth to two healthy babies while taking this drug. A few potential side effects to be aware of are easy bruising and slightly elevated blood pressure, both of which I've experienced myself. All things considered, though, I believe this medication is safe and effective when used responsibly under a doctor's supervision.
4Patient Review
10/22/2011 This medication has been great for my Crohn's. I'm able to eat whatever I want and have even gained back all the weight I lost. The only downside is that I worry about long-term effects, but it's been four years and I haven't missed a day of work yet, so fingers crossed!
3.7Patient Review
12/24/2007 I've been on this medication for three months now and unfortunately have not seen any improvement in my Chron's Disease. I constantly feel tired, and my joints are starting to hurt more and more. It's becoming difficult to walk, especially after sitting or lying down for a while. And if I get even the slightest cut or scrape, it gets infected very easily if I don't catch it right away and use antibiotic cream.
3.3Patient Review
12/8/20072.7Patient Review
11/2/20072Patient Review
2/4/2014 I'm on my third week of treatment, and I've started having severe abdominal pain and diarrhea. My doctor says that if I get the flu or anything else, I should stop taking the medication until I recover. I'm just sick of being sick!
1Patient Review
12/9/2008 I have used this treatment for three months and it has helped with my Crohn's disease and arthritis. I believe it is responsible for my remission.
Patient Q&A Section about azasan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Azasan an immunosuppressant?
"Azasan is a drug that is part of a class of drugs called DMARDs. These are drugs that help to regulate the immune system, and Azasan specifically helps to suppress the immune system."
Answered by AI
What is Azasan used for?
"Azathioprine is a medication used to prevent organ rejection in people who have received a kidney transplant. It is usually taken along with other medications to help the new kidney function properly. Azathioprine is also used to treat rheumatoid arthritis."
Answered by AI
Is Azasan a steroid?
"This medication belongs to a class of drugs called immunomodulators, which help to reduce irritation and swelling (inflammation) in the intestines. It also decreases the long-term need for steroids, making it sometimes referred to as a "steroid-sparing" drug."
Answered by AI
Is Azasan and azathioprine the same?
"Azathioprine is a drug that reduces the activity of the immune system. It is used to stop the body from rejecting a transplanted kidney. It is also used to treat the symptoms of rheumatoid arthritis."
Answered by AI