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What is Atenolol And Chlorthalidone
ChlorthalidoneThe Generic name of this drug
Treatment SummaryAtenolol is a medication used to treat various heart conditions. It was developed in the 1960s and approved by the FDA in 1981. It is one of the most commonly prescribed beta blockers, but it has been shown to only modestly reduce the risk of cardiovascular disease in people with hypertension. It may also not significantly reduce mortality in some patients. The use of atenolol may need to be based on more factors than just hypertension.
Chlorthalidoneis the brand name
Atenolol And Chlorthalidone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorthalidone
Chlorthalidone
1981
193
Effectiveness
How Atenolol And Chlorthalidone Affects PatientsAtenolol is a type of medication used to treat heart-related conditions. It slows down the rate of the heart and reduces the amount of work it needs to do, which helps oxygen flow to the heart more efficiently. This can reduce the frequency of chest pain in people with coronary artery disease. Atenolol also affects the nervous system, which can lead to side effects like fatigue, depression, and insomnia. It can also cause breathing issues in people with asthma or chronic obstructive pulmonary disease. Atenolol does not affect blood sugar levels and does not have any other stimulant effects.
How Atenolol And Chlorthalidone works in the bodyAtenolol is a type of drug that blocks the effects of adrenaline on the heart and lungs. It does this by targeting specific receptors that control how the heart and lungs respond to adrenaline. In the heart, atenolol reduces the activity of certain proteins and molecules that cause the heart to beat faster. This helps the heart beat at a regular rate and with more force. In the lungs, atenolol blocks the receptors that cause bronchoconstriction, or constriction of the airways. This helps to open up the airways and improve breathing.
When to interrupt dosage
The amount of Atenolol And Chlorthalidone is contingent on the diagnosed condition, for instance Atrial Fibrillation, Migraine and Hypertensive disease. Dose varies based on the method of delivery (e.g. Tablet - Oral or Tablet) as specified in the table underneath.Condition
Dosage
Administration
not adequately controlled with monotherapy
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
multiple antihypertensive drugs likely required
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Cirrhosis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Atenolol And Chlorthalidone ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
Common Atenolol And Chlorthalidone Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Chlorthalidone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Hexamethonium.
Lithium carbonate
Major
Chlorthalidone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Atenolol And Chlorthalidone Toxicity & Overdose RiskThe toxic dose of Atenolol in mice is 2g/kg when taken orally, 57mg/kg when injected intravenously, 134mg/kg when injected into the muscle, and 400mg/kg when given under the skin. The toxic dose in rats is 2g/kg when taken orally, 77mg/kg when injected intravenously, and 600mg/kg when given under the skin. The toxic dose in rabbits is 50mg/kg when injected intravenously. Studies of rats and mice at doses of 300mg/kg/day (150 times the maximum recommended human dose) for 18-24
Atenolol And Chlorthalidone Novel Uses: Which Conditions Have a Clinical Trial Featuring Atenolol And Chlorthalidone?
Presently, 626 active studies are investigating the potential of Atenolol and Chlorthalidone in counteracting Atrial Fibrillation, Coronary Artery Atherosclerosis and Ventricular Tachycardia.Condition
Clinical Trials
Trial Phases
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Chronic Kidney Disease (CKD)
245 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
multiple antihypertensive drugs likely required
0 Actively Recruiting
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Nephrolithiasis
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Atenolol And Chlorthalidone Reviews: What are patients saying about Atenolol And Chlorthalidone?
5Patient Review
6/28/2015 I have bruises on my arms and legs that I don't know how I got.
5Patient Review
8/14/2012 Worked great for me and was easy to use, but now I'm experiencing erectile dysfunction.
5Patient Review
6/17/20125Patient Review
6/18/2013 I immediately felt better after taking this medication. I didn't realize the excess water was affecting my blood pressure.
4.7Patient Review
10/23/2015 I gained a lot of weight while taking this medication. I'm thinking about trying another blood pressure medication because of that reason.
4.7Patient Review
8/18/2012 This treatment has helped me tremendously with my stomach pain, bone pain, and bloating. I'm feeling so much better now and would highly recommend it to others!
4Patient Review
4/23/2013 I experience shortness of breath and a loss of energy when I do any physical activity. Additionally, my joints have been hurting more, but I'm not sure if the drug is to blame. However, I do appreciate the pressure readings that are taken while on the medication.
4Patient Review
8/13/20123.7Patient Review
4/10/2013 Almost immediately after starting this medication, I began to experience kidney and lower back pain. This worsened over time, to the point where my doctor had to put me on other medication for the pain. Thankfully, once I stopped taking this treatment, the pain subsided.
3.7Patient Review
4/9/2015 The medication for my high blood pressure left me feeling so exhausted that I couldn't bring myself to do anything, including the things that would help lower my blood pressure. It's a vicious cycle.
3.7Patient Review
8/31/2014 I took this for five days as directed, but I found myself struggling to stay awake in the afternoons. On the fifth night, I woke up in agony with leg, ankle, foot, and toe cramps. Additionally, I developed a cold sore that only abated when I started taking valtrex.
3.7Patient Review
2/4/2017 I've been on 100-25 mg of this medication for about a year. My blood pressure has gone down, but I'm always exhausted and have no motivation to do anything. It's frustrating when I have a lot that I need or want to get done in a day, and I can't even summon the energy to get off the couch.
3.3Patient Review
10/23/2012 I have put on 20 pounds since I started taking this medication. Additionally, my feet and ankles are often swollen.
3.3Patient Review
10/3/2016 I've been on this medication for over 8 months and it has helped my numbers a lot. However, I am experiencing some side effects that are concerning me. First, I am very active in tennis and biking. I am noticing my level of energy has decreased, I had a bout with gout, my ankles get swollen and big toe joint pain. Not to mention ED as well. If these side effects are from the drug, then I need to ween off of it.
3Patient Review
2/13/2013 I've been sweating a lot more since taking this medication, to the point where it's really bothersome. My blood pressure is also all over the place, which wasn't an issue before. The water pill makes me have to go to the bathroom constantly, and I'm already pretty used to the med after 10 years. I might need to ask my doctor for something different.
3Patient Review
9/16/2014 After trying another blood pressure medication that resulted in a chronic cough, I decided to switch to this one. It worked great for my blood pressure, but after a couple months I started experiencing some frustrating side effects like dry mouth, weight gain, and extreme dizziness when getting up. Additionally, I found myself with a sore and stiff lower back whenever I stood up. In the end, these problems were too much so I stopped taking the medication.
3Patient Review
6/8/2017 I've been on a 50/25 dosage for three years. Age is 77. Blood pressure stays in the 130/90 range. After starting a beet juice and part time vegetarian regimen six months ago my bp dropped to 110/67. I still wake up three to four times a night to empty a full bladder. Also experience toe and ankle cramps. Both ankles are usually slightly swollen.
2.3Patient Review
3/5/2013 I'm not thrilled with this medication because I've started to lose hair since taking it. Has anyone else had this issue? Is there anything I can do to mitigate the side effect?
Patient Q&A Section about atenolol and chlorthalidone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of atenolol chlorthalidone 50 25?
"Side effects including dizziness, lightheadedness, tiredness, nausea, and diarrhea may occur. To reduce the risk of these side effects, get up slowly when rising from a sitting or lying position. Additionally, this product may reduce blood flow to your hands and feet, causing them to feel cold."
Answered by AI
Can you take chlorthalidone and atenolol together?
"Atenolol and chlorthalidone combination is used to treat high blood pressure (hypertension). High blood pressure puts extra strain on the heart and arteries. If it is not treated, it can cause long-term damage to the heart and arteries."
Answered by AI
Can you take a water pill with atenolol?
"The following is a list of interactions between your drugs. Taking atenolol and hydrochlorothiazide together may lower your blood pressure and slow your heart rate. This can cause dizziness, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control."
Answered by AI
What is the brand name for atenolol and chlorthalidone?
"Tenoretic is a combination medication that contains atenolol and chlorthalidone. It helps to lower blood pressure, which in turn lowers the risk of heart attack and stroke."
Answered by AI