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What is Atenolol And Chlorthalidone
ChlorthalidoneThe Generic name of this drug
Treatment SummaryAtenolol is a medication used to treat various heart conditions. It was developed in the 1960s and approved by the FDA in 1981. It is one of the most commonly prescribed beta blockers, but it has been shown to only modestly reduce the risk of cardiovascular disease in people with hypertension. It may also not significantly reduce mortality in some patients. The use of atenolol may need to be based on more factors than just hypertension.
Chlorthalidoneis the brand name
Atenolol And Chlorthalidone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorthalidone
Chlorthalidone
1981
193
Effectiveness
How Atenolol And Chlorthalidone Affects PatientsAtenolol is a type of medication used to treat heart-related conditions. It slows down the rate of the heart and reduces the amount of work it needs to do, which helps oxygen flow to the heart more efficiently. This can reduce the frequency of chest pain in people with coronary artery disease. Atenolol also affects the nervous system, which can lead to side effects like fatigue, depression, and insomnia. It can also cause breathing issues in people with asthma or chronic obstructive pulmonary disease. Atenolol does not affect blood sugar levels and does not have any other stimulant effects.
How Atenolol And Chlorthalidone works in the bodyAtenolol is a type of drug that blocks the effects of adrenaline on the heart and lungs. It does this by targeting specific receptors that control how the heart and lungs respond to adrenaline. In the heart, atenolol reduces the activity of certain proteins and molecules that cause the heart to beat faster. This helps the heart beat at a regular rate and with more force. In the lungs, atenolol blocks the receptors that cause bronchoconstriction, or constriction of the airways. This helps to open up the airways and improve breathing.
When to interrupt dosage
The amount of Atenolol And Chlorthalidone is contingent on the diagnosed condition, for instance Atrial Fibrillation, Migraine and Hypertensive disease. Dose varies based on the method of delivery (e.g. Tablet - Oral or Tablet) as specified in the table underneath.Condition
Dosage
Administration
Hypertensive disease
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
multiple antihypertensive drugs likely required
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
not adequately controlled with monotherapy
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Cirrhosis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Atenolol And Chlorthalidone ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
Common Atenolol And Chlorthalidone Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Chlorthalidone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Hexamethonium.
Lithium carbonate
Major
Chlorthalidone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Atenolol And Chlorthalidone Toxicity & Overdose RiskThe toxic dose of Atenolol in mice is 2g/kg when taken orally, 57mg/kg when injected intravenously, 134mg/kg when injected into the muscle, and 400mg/kg when given under the skin. The toxic dose in rats is 2g/kg when taken orally, 77mg/kg when injected intravenously, and 600mg/kg when given under the skin. The toxic dose in rabbits is 50mg/kg when injected intravenously. Studies of rats and mice at doses of 300mg/kg/day (150 times the maximum recommended human dose) for 18-24
Atenolol And Chlorthalidone Novel Uses: Which Conditions Have a Clinical Trial Featuring Atenolol And Chlorthalidone?
Presently, 626 active studies are investigating the potential of Atenolol and Chlorthalidone in counteracting Atrial Fibrillation, Coronary Artery Atherosclerosis and Ventricular Tachycardia.Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
26 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
not adequately controlled with monotherapy
0 Actively Recruiting
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
multiple antihypertensive drugs likely required
0 Actively Recruiting
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
Nephrolithiasis
0 Actively Recruiting
Atenolol And Chlorthalidone Reviews: What are patients saying about Atenolol And Chlorthalidone?
5Patient Review
6/28/2015 I have bruises on my arms and legs that I don't know how I got.
5Patient Review
8/14/2012 Worked great for me and was easy to use, but now I'm experiencing erectile dysfunction.
5Patient Review
6/17/20125Patient Review
6/18/2013 I immediately felt better after taking this medication. I didn't realize the excess water was affecting my blood pressure.
4.7Patient Review
10/23/2015 I gained a lot of weight while taking this medication. I'm thinking about trying another blood pressure medication because of that reason.
Patient Q&A Section about atenolol and chlorthalidone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of atenolol chlorthalidone 50 25?
"Side effects including dizziness, lightheadedness, tiredness, nausea, and diarrhea may occur. To reduce the risk of these side effects, get up slowly when rising from a sitting or lying position. Additionally, this product may reduce blood flow to your hands and feet, causing them to feel cold."
Answered by AI
Can you take chlorthalidone and atenolol together?
"Atenolol and chlorthalidone combination is used to treat high blood pressure (hypertension). High blood pressure puts extra strain on the heart and arteries. If it is not treated, it can cause long-term damage to the heart and arteries."
Answered by AI
Can you take a water pill with atenolol?
"The following is a list of interactions between your drugs. Taking atenolol and hydrochlorothiazide together may lower your blood pressure and slow your heart rate. This can cause dizziness, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control."
Answered by AI
What is the brand name for atenolol and chlorthalidone?
"Tenoretic is a combination medication that contains atenolol and chlorthalidone. It helps to lower blood pressure, which in turn lowers the risk of heart attack and stroke."
Answered by AI
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