What is Duac
Benzoyl peroxideThe Generic name of this drug
Treatment SummaryBenzoyl peroxide is a medication used in topical treatments for acne. It can be found in products with one active ingredient or in combination with other acne-fighting ingredients such as erythromycin, clindamycin, or adapalene. When applied to the skin, benzoyl peroxide breaks down and releases oxygen molecules that interact with proteins. This helps reduce the production of keratin and sebum around follicles and increase cell turnover. The FDA approved benzoyl peroxide in combination with erythromycin in 1984.
Erythromycin-Benzoyl Peroxideis the brand name
Duac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Erythromycin-Benzoyl Peroxide
Benzoyl peroxide
1984
79
Effectiveness
How Duac Affects PatientsBenzoyl peroxide is a medicine used to treat acne. It works by creating free radicals which help to break down pimples and speed up the growth of new skin cells. It wears off quickly, so overdoses are rare. However, it can cause skin irritation, dryness and sunburn, so patients should be aware of these possible side effects.
How Duac works in the bodyAcne is caused by inflammation around the skin's oil glands, hormone levels, and bacteria. Benzoyl peroxide helps clear acne by breaking down the bacteria that cause it, decreasing oil and keratin around skin follicles, and increasing the rate at which skin cells turn over. This helps to break down comedones, which are whiteheads and blackheads associated with acne.
When to interrupt dosage
The measure of Duac is contingent upon the diagnosed complaint, including Inflammatory Acne Vulgaris, Acne and Acne. The amount of dosage can be found in the table below, contingent upon the mode of delivery (e.g. Solution or Kit - Topical).Condition
Dosage
Administration
Acne
25.0 mg/mL, 0.04 mg/mg, 0.075 mL/mL, 0.05 mg/mg, 100.0 mg/mL, 0.025 mg/mg, 0.1 mg/mg, 10.0 mg/mL, 5.0 mg/mL, 0.136 mg/mg, 0.01 mg/mg, 90.0 mg/mL, 60.0 mg/mL, 57.5 mg/mL, 0.03 mg/mg, 0.005 mg/mg, 35.0 mg/mL, 70.0 mg/mL, , 0.025 mg/mL, 0.0587 mg/mg, 65.0 mg/mL, 0.14 mg/mg, 2.75 mg, 0.06 mg/mg, 0.1467 mg/mg, 0.15 mg/mg, 61.62 mg/mL, 0.095 mg/mg, 37.0 mg/mL, 0.00557 mg/mg, 0.329 mg/mg, 2.5 %, 30.0 mg/mL, 3.0 %, 0.000085 mg/mg, 2.5 mg/mL, 44.0 mg/mL, 0.07 mg/mg, 0.035 mg/mg, 42.5 mg/mL, 5.0 %, 0.0425 mg/mg, 4.0 %, 0.3 mL/mL, 0.519 mg/mL, 0.069 mg/mg, 0.56 mg/mg, 50.0 mg/mL, 0.053 mg/mg, 0.0375 mg/mg, 0.098 mg/mg, 0.085 mg/mL, 0.0948 mg/mg, 0.0025 %/mg, 125.0 mg/mL, 50.0 mg, 25000.0 mg/mL, 0.025 mL/mL, 62.0 mg/mL, 0.3 mg/mL, 26.0 mg/mL, 10.0 %, 0.007 mg/mg, 0.07 mg/mL, 0.25 mg/mL, 0.8 mg/mg, 0.295 mL/mL, 0.135 mg/mg, 0.0104 mg/mg, 0.032 mg/mg, 0.055 mg/mg, 0.318 mg/mg, 0.0525 mg/mg, 0.034 mg/mg, 0.05 mg/mL, 0.08 mg/mg, 55.0 mg/mL, 20.0 %, 0.1125 mg/mg, 0.125 mg/mg, 11300.0 mg, 3.5 %, 2.6 %, 0.22 mg/mL, 0.6 mg/mg, 5650.0 mg, 75.0 mg/mL, 0.026 mg/mg, 0.0025 mg/mg, 0.1 mg/mL, 25.0 mg, 0.05 mL/mL, 0.09 mg/mg, 0.1 mL/mL, 3.7 %, 8.0 %, 52.5 mg/mL, 0.045 mg/mL, 200.0 mg/mL, 0.063 mg/mL, 500.0 mg/mL, 0.085 mg/mg, 45.0 mg/mL, 0.0001 mg/mg, 0.068 mg/mg, 0.2 mg/mg, 85.0 mg/mL, 0.283 mg/mg, 36.9 mg/mL, 0.02 mg/mg, 0.037 mL/mL, 50000.0 mg/mL, 0.001 mg/mg, 0.0005 mg/mg, 60.0 mg, 115.0 mg/mL, 40.0 mg/mL, 0.35 mg/mg, 0.5 mg/mg, 0.0275 mg/mg, 70000.0 mg/mL, 0.102 mg/mg, 0.1173 mg/mg, 0.0625 mg/mg, 9.8 mg/mg, 0.075 mg/mL, 0.28 mg/mg, 0.13 mg/mg
Solution, Kit - Topical, Cream; Gel; Kit; Lotion, , Cream - Topical, Topical, Liquid - Topical, Cloth; Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution - Topical, Gel; Kit, Kit; Soap, Gel, Emulsion, Cream, Solution - Topical, Lotion - Topical, Jelly, Gel - Topical, Soap - Topical, Kit, Aerosol, foam - Topical, Gel; Lotion, Liquid, Lotion, Soap, Aerosol - Topical, Gel; Kit; Lotion - Topical, Kit; Liquid; Lotion - Topical, Kit; Soap - Topical, Aerosol, foam, Ointment, Kit; Lotion, Gel; Kit; Liquid - Topical, Cloth, Oil, Suspension, Gel; Kit - Topical, Gel; Kit; Paste, Kit; Lotion; Solution - Topical, Shampoo, suspension - Topical, Emulsion - Topical, Kit; Liquid; Lotion, Oil - Topical, Kit; Lotion - Topical, Cream; Gel; Kit; Lotion - Topical, Aerosol, Cloth - Topical, Gel; Lotion - Topical, Gel; Kit; Lotion, Cream; Kit; Lotion, Gel; Kit; Liquid, Ointment - Topical, Cream; Kit, Swab - Topical, Stick, Paste - Topical, Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution, Cloth; Cream; Kit; Lotion, Cream; Gel; Kit, Stick - Topical, Shampoo, suspension, Liquid, extended release - Topical, Jelly - Topical, Transdermal, Swab, Kit; Lotion; Solution, Cream; Gel; Kit - Topical, Lotion - Transdermal, Suspension - Topical, Lotion / shampoo - Topical, Liquid, extended release, Cream; Kit - Topical, Gel; Kit; Paste - Topical, Paste, Lotion / shampoo
Inflammatory Acne Vulgaris
25.0 mg/mL, 0.04 mg/mg, 0.075 mL/mL, 0.05 mg/mg, 100.0 mg/mL, 0.025 mg/mg, 0.1 mg/mg, 10.0 mg/mL, 5.0 mg/mL, 0.136 mg/mg, 0.01 mg/mg, 90.0 mg/mL, 60.0 mg/mL, 57.5 mg/mL, 0.03 mg/mg, 0.005 mg/mg, 35.0 mg/mL, 70.0 mg/mL, , 0.025 mg/mL, 0.0587 mg/mg, 65.0 mg/mL, 0.14 mg/mg, 2.75 mg, 0.06 mg/mg, 0.1467 mg/mg, 0.15 mg/mg, 61.62 mg/mL, 0.095 mg/mg, 37.0 mg/mL, 0.00557 mg/mg, 0.329 mg/mg, 2.5 %, 30.0 mg/mL, 3.0 %, 0.000085 mg/mg, 2.5 mg/mL, 44.0 mg/mL, 0.07 mg/mg, 0.035 mg/mg, 42.5 mg/mL, 5.0 %, 0.0425 mg/mg, 4.0 %, 0.3 mL/mL, 0.519 mg/mL, 0.069 mg/mg, 0.56 mg/mg, 50.0 mg/mL, 0.053 mg/mg, 0.0375 mg/mg, 0.098 mg/mg, 0.085 mg/mL, 0.0948 mg/mg, 0.0025 %/mg, 125.0 mg/mL, 50.0 mg, 25000.0 mg/mL, 0.025 mL/mL, 62.0 mg/mL, 0.3 mg/mL, 26.0 mg/mL, 10.0 %, 0.007 mg/mg, 0.07 mg/mL, 0.25 mg/mL, 0.8 mg/mg, 0.295 mL/mL, 0.135 mg/mg, 0.0104 mg/mg, 0.032 mg/mg, 0.055 mg/mg, 0.318 mg/mg, 0.0525 mg/mg, 0.034 mg/mg, 0.05 mg/mL, 0.08 mg/mg, 55.0 mg/mL, 20.0 %, 0.1125 mg/mg, 0.125 mg/mg, 11300.0 mg, 3.5 %, 2.6 %, 0.22 mg/mL, 0.6 mg/mg, 5650.0 mg, 75.0 mg/mL, 0.026 mg/mg, 0.0025 mg/mg, 0.1 mg/mL, 25.0 mg, 0.05 mL/mL, 0.09 mg/mg, 0.1 mL/mL, 3.7 %, 8.0 %, 52.5 mg/mL, 0.045 mg/mL, 200.0 mg/mL, 0.063 mg/mL, 500.0 mg/mL, 0.085 mg/mg, 45.0 mg/mL, 0.0001 mg/mg, 0.068 mg/mg, 0.2 mg/mg, 85.0 mg/mL, 0.283 mg/mg, 36.9 mg/mL, 0.02 mg/mg, 0.037 mL/mL, 50000.0 mg/mL, 0.001 mg/mg, 0.0005 mg/mg, 60.0 mg, 115.0 mg/mL, 40.0 mg/mL, 0.35 mg/mg, 0.5 mg/mg, 0.0275 mg/mg, 70000.0 mg/mL, 0.102 mg/mg, 0.1173 mg/mg, 0.0625 mg/mg, 9.8 mg/mg, 0.075 mg/mL, 0.28 mg/mg, 0.13 mg/mg
Solution, Kit - Topical, Cream; Gel; Kit; Lotion, , Cream - Topical, Topical, Liquid - Topical, Cloth; Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution - Topical, Gel; Kit, Kit; Soap, Gel, Emulsion, Cream, Solution - Topical, Lotion - Topical, Jelly, Gel - Topical, Soap - Topical, Kit, Aerosol, foam - Topical, Gel; Lotion, Liquid, Lotion, Soap, Aerosol - Topical, Gel; Kit; Lotion - Topical, Kit; Liquid; Lotion - Topical, Kit; Soap - Topical, Aerosol, foam, Ointment, Kit; Lotion, Gel; Kit; Liquid - Topical, Cloth, Oil, Suspension, Gel; Kit - Topical, Gel; Kit; Paste, Kit; Lotion; Solution - Topical, Shampoo, suspension - Topical, Emulsion - Topical, Kit; Liquid; Lotion, Oil - Topical, Kit; Lotion - Topical, Cream; Gel; Kit; Lotion - Topical, Aerosol, Cloth - Topical, Gel; Lotion - Topical, Gel; Kit; Lotion, Cream; Kit; Lotion, Gel; Kit; Liquid, Ointment - Topical, Cream; Kit, Swab - Topical, Stick, Paste - Topical, Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution, Cloth; Cream; Kit; Lotion, Cream; Gel; Kit, Stick - Topical, Shampoo, suspension, Liquid, extended release - Topical, Jelly - Topical, Transdermal, Swab, Kit; Lotion; Solution, Cream; Gel; Kit - Topical, Lotion - Transdermal, Suspension - Topical, Lotion / shampoo - Topical, Liquid, extended release, Cream; Kit - Topical, Gel; Kit; Paste - Topical, Paste, Lotion / shampoo
Acne Vulgaris
25.0 mg/mL, 0.04 mg/mg, 0.075 mL/mL, 0.05 mg/mg, 100.0 mg/mL, 0.025 mg/mg, 0.1 mg/mg, 10.0 mg/mL, 5.0 mg/mL, 0.136 mg/mg, 0.01 mg/mg, 90.0 mg/mL, 60.0 mg/mL, 57.5 mg/mL, 0.03 mg/mg, 0.005 mg/mg, 35.0 mg/mL, 70.0 mg/mL, , 0.025 mg/mL, 0.0587 mg/mg, 65.0 mg/mL, 0.14 mg/mg, 2.75 mg, 0.06 mg/mg, 0.1467 mg/mg, 0.15 mg/mg, 61.62 mg/mL, 0.095 mg/mg, 37.0 mg/mL, 0.00557 mg/mg, 0.329 mg/mg, 2.5 %, 30.0 mg/mL, 3.0 %, 0.000085 mg/mg, 2.5 mg/mL, 44.0 mg/mL, 0.07 mg/mg, 0.035 mg/mg, 42.5 mg/mL, 5.0 %, 0.0425 mg/mg, 4.0 %, 0.3 mL/mL, 0.519 mg/mL, 0.069 mg/mg, 0.56 mg/mg, 50.0 mg/mL, 0.053 mg/mg, 0.0375 mg/mg, 0.098 mg/mg, 0.085 mg/mL, 0.0948 mg/mg, 0.0025 %/mg, 125.0 mg/mL, 50.0 mg, 25000.0 mg/mL, 0.025 mL/mL, 62.0 mg/mL, 0.3 mg/mL, 26.0 mg/mL, 10.0 %, 0.007 mg/mg, 0.07 mg/mL, 0.25 mg/mL, 0.8 mg/mg, 0.295 mL/mL, 0.135 mg/mg, 0.0104 mg/mg, 0.032 mg/mg, 0.055 mg/mg, 0.318 mg/mg, 0.0525 mg/mg, 0.034 mg/mg, 0.05 mg/mL, 0.08 mg/mg, 55.0 mg/mL, 20.0 %, 0.1125 mg/mg, 0.125 mg/mg, 11300.0 mg, 3.5 %, 2.6 %, 0.22 mg/mL, 0.6 mg/mg, 5650.0 mg, 75.0 mg/mL, 0.026 mg/mg, 0.0025 mg/mg, 0.1 mg/mL, 25.0 mg, 0.05 mL/mL, 0.09 mg/mg, 0.1 mL/mL, 3.7 %, 8.0 %, 52.5 mg/mL, 0.045 mg/mL, 200.0 mg/mL, 0.063 mg/mL, 500.0 mg/mL, 0.085 mg/mg, 45.0 mg/mL, 0.0001 mg/mg, 0.068 mg/mg, 0.2 mg/mg, 85.0 mg/mL, 0.283 mg/mg, 36.9 mg/mL, 0.02 mg/mg, 0.037 mL/mL, 50000.0 mg/mL, 0.001 mg/mg, 0.0005 mg/mg, 60.0 mg, 115.0 mg/mL, 40.0 mg/mL, 0.35 mg/mg, 0.5 mg/mg, 0.0275 mg/mg, 70000.0 mg/mL, 0.102 mg/mg, 0.1173 mg/mg, 0.0625 mg/mg, 9.8 mg/mg, 0.075 mg/mL, 0.28 mg/mg, 0.13 mg/mg
Solution, Kit - Topical, Cream; Gel; Kit; Lotion, , Cream - Topical, Topical, Liquid - Topical, Cloth; Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution - Topical, Gel; Kit, Kit; Soap, Gel, Emulsion, Cream, Solution - Topical, Lotion - Topical, Jelly, Gel - Topical, Soap - Topical, Kit, Aerosol, foam - Topical, Gel; Lotion, Liquid, Lotion, Soap, Aerosol - Topical, Gel; Kit; Lotion - Topical, Kit; Liquid; Lotion - Topical, Kit; Soap - Topical, Aerosol, foam, Ointment, Kit; Lotion, Gel; Kit; Liquid - Topical, Cloth, Oil, Suspension, Gel; Kit - Topical, Gel; Kit; Paste, Kit; Lotion; Solution - Topical, Shampoo, suspension - Topical, Emulsion - Topical, Kit; Liquid; Lotion, Oil - Topical, Kit; Lotion - Topical, Cream; Gel; Kit; Lotion - Topical, Aerosol, Cloth - Topical, Gel; Lotion - Topical, Gel; Kit; Lotion, Cream; Kit; Lotion, Gel; Kit; Liquid, Ointment - Topical, Cream; Kit, Swab - Topical, Stick, Paste - Topical, Cream; Kit; Lotion - Topical, Gel; Kit; Powder, for solution, Cloth; Cream; Kit; Lotion, Cream; Gel; Kit, Stick - Topical, Shampoo, suspension, Liquid, extended release - Topical, Jelly - Topical, Transdermal, Swab, Kit; Lotion; Solution, Cream; Gel; Kit - Topical, Lotion - Transdermal, Suspension - Topical, Lotion / shampoo - Topical, Liquid, extended release, Cream; Kit - Topical, Gel; Kit; Paste - Topical, Paste, Lotion / shampoo
Warnings
Duac has six acknowledged contraindications and should not be used in conjunction with the conditions listed in the following table.Duac ContraindicationsCondition
Risk Level
Notes
History of Antibiotics Associated Colitis
Do Not Combine
pseudomembranous colitis
Do Not Combine
History of Regional Enteritis
Do Not Combine
History of Ulcerative Colitis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Benzoyl Peroxide may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Benzoyl Peroxide may interact with Toxoplasma Infections
Common Duac Drug Interactions
Drug Name
Risk Level
Description
Dapsone
Minor
The risk or severity of adverse effects can be increased when Benzoyl peroxide is combined with Dapsone.
Duac Toxicity & Overdose RiskThere is limited data on overdoses of benzoyl peroxide, but an overdose may cause increased skin irritation, itching, burning, flaking, redness and swelling. The lowest toxic dose of benzoyl peroxide in rats has been found to be 490mg/kg.
Duac Novel Uses: Which Conditions Have a Clinical Trial Featuring Duac?
23 active studies are investigating the potential of Duac to alleviate Inflammatory Acne Vulgaris, Acne and other Acne-related maladies.Condition
Clinical Trials
Trial Phases
Inflammatory Acne Vulgaris
1 Actively Recruiting
Not Applicable
Acne Vulgaris
18 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1
Acne
7 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable
Duac Reviews: What are patients saying about Duac?
5Patient Review
5/27/2009 My daughter's acne was getting out of control, so we decided to go the prescription route. Duac + Differin cleared up her skin within just a few weeks and she's been using it successfully for over a year now.
5Patient Review
12/13/2010 I'm an Indian woman in my early twenties. When I first moved to the States, I had a lot of acne. My doctor prescribed me Duac and Differin, which I used for one month. After using both products religiously, my face was finally clear!
5Patient Review
10/7/2018 Duac was a total lifesaver for me. My acne got really bad about a year ago, to the point where I was too embarrassed to leave my house. But after just two months of using this treatment, my skin completely cleared up! I still get the odd pimple here and there, but it's nothing compared to what it used to be. If you're struggling with acne, I would highly recommend giving duac a try.
5Patient Review
7/25/2016 Despite the burning sensation and itchiness I felt at first, this product has yielded amazing results in just two weeks.
5Patient Review
12/3/2010 This product is amazing. I'm 56 years old and had been using Accutane to clear up my cystic acne (which trust me, really hurts). This product completely cleared up my acne and has prevented others from starting. You need to make sure to use a very thin layer--if you use too much you really can have dry skin. My skin looks wonderful now and this is so much cheaper than trying to have an Rx for Retin-A ($220+).
4.7Patient Review
1/15/2016 I've only been using this product for a week, and I can already see a significant difference in my skin quality. I'm much more confident about going makeup-free now.
4.3Patient Review
4/21/2019 I've been using this for a while and it works great on my acne. If I stop using it, the acne comes back, but not as bad. So, I just keep using it. Not everyone likes that you have to keep using it to see results, but I would still recommend it.
3.7Patient Review
2/28/2009 My skin looked great the first week after starting this treatment. However, I started experiencing some uncomfortable side effects like stomach aches and nausea. Additionally, my acne is starting to come back and it doesn't help with red spots. This medication will dry out your face, so be sure to use a good non-oily lotion.
3Patient Review
9/26/2009 Unfortunately, this product had terrible side effects for me. My skin became incredibly dry and itchy, to the point where I was constantly scratching and flaking. And once I stopped using the medicine, I broke out in hives that were really embarrassing because they were on my face.
2.7Patient Review
3/27/2012 I've been using Duac for five years now, and it's helped somewhat but my acne is still very much a problem. It's also dried out my skin something fierce.
2.3Patient Review
9/24/2018 At first, duac helped my acne clear up a lot. But after using it for two years straight, I stopped for a week and all the progress I made disappeared. Not only that, but my skin became thin and dehydrated. Now I'm seeing a cosmetician on a regular basis and my skin is improving.
1.7Patient Review
3/1/2016 I've been using this product for a 2 months and my face has gone worse!!!My face has gotten red and very itchy and i think more pimples have sprung up. I dont like this product.
1Patient Review
1/19/2010 DO NOT USE THIS CREAM! I tried it last night for some breakouts and woke up with my face burning, red, and itching. It's so bad that I had to miss school today. A tiny bit of this cream went a long way... in the worst possible way.
1Patient Review
10/18/2009 I don't understand why anyone would spend so much money on this when you can get the same thing for way less.
Patient Q&A Section about duac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Duac used for?
"DUAC ONCE DAILY GEL is an acne medication that contains clindamycin and benzoyl peroxide. Clindamycin is an antibiotic that kills the bacteria that cause acne, while benzoyl peroxide reduces the number of blackheads and whiteheads."
Answered by AI
Is Duac the same as clindamycin?
"Therefore, caution should be exercised when DUAC Gel is corporation to a nursing woman.
One of the ingredients in DUAC Gel is clindamycin, which has been known to be present in breast milk when taken orally or by injection. Therefore, DUAC Gel should be used with caution when administered to a nursing woman."
Answered by AI
Is Duac cream good for acne?
"What are the two active ingredients in Duac gel? How long can it take to see results from using Duac gel? Can Duac gel be used for more than 12 weeks?"
Answered by AI