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What is Aralen
ChloroquineThe Generic name of this drug
Treatment SummaryChloroquine is a drug that was developed in the 1940s to treat malaria. For a long time, it was the most common treatment for malaria until newer drugs like pyrimethamine, artemisinin, and mefloquine were created. In recent years, chloroquine and its derivative hydroxychloroquine have been used to treat other conditions such as HIV, lupus, and rheumatoid arthritis. In 2020, the FDA gave emergency use authorization for hydroxychloroquine and chloroquine as treatments for COVID-19, but this authorization was revoked in June. Chlor
Aralenis the brand name
Aralen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aralen
Chloroquine
1972
22
Approved as Treatment by the FDA
Chloroquine, also called Aralen, is approved by the FDA for 4 uses which include Extraintestinal Amebiasis and acute, uncomplicated Malaria .Extraintestinal Amebiasis
acute, uncomplicated Malaria
prophylaxis of Malaria
Malaria
Effectiveness
How Aralen Affects PatientsChloroquine stops the growth of a certain type of parasite. It is effective for a long time, with a half-life of up to two months. It is important to warn patients that taking this drug for an extended period of time or in large doses can cause vision problems, muscle weakness, and potential toxicity in children.
How Aralen works in the bodyChloroquine works against malaria by stopping a molecule called heme polymerase from converting heme into a toxic compound. It also stops viruses from entering cells by increasing the pH of certain organelles, like endosomes and lysosomes. Chloroquine also affects the glycosylation state of ACE2, which is the receptor that SARS-CoV and SARS-CoV-2 use to enter cells. This makes it harder for the virus to attach to the ACE2 receptor and enter the cell.
When to interrupt dosage
The measure of Aralen is based upon the diagnosed condition, such as Porphyria Cutanea Tarda, Actinic prurigo and acute, uncomplicated Malaria. The amount also depends on the procedure of delivery specified in the table beneath.Condition
Dosage
Administration
Lupus Erythematosus, Discoid
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
acute, uncomplicated Malaria
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Sarcoidosis
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Rheumatoid Arthritis
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
prophylaxis of Malaria
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Malaria
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Porphyria Cutanea Tarda
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Extraintestinal Amebiasis
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Actinic prurigo
, 250.0 mg, 500.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Aralen ContraindicationsCondition
Risk Level
Notes
visual field changes
Do Not Combine
retinal changes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Chloroquine may interact with Pulse Frequency
Common Aralen Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Acetophenazine.
Agalsidase beta
Major
The therapeutic efficacy of Agalsidase beta can be decreased when used in combination with Chloroquine.
Alimemazine
Major
The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Alimemazine.
Aralen Toxicity & Overdose RiskAn overdose of Metoprolol can cause headaches, drowsiness, vision problems, nausea, vomiting, low potassium levels, shock, seizures, difficulty breathing, heart failure, and cardiovascular collapse. Treatment for an overdose may include inducing vomiting, cleaning the stomach with a tube, and giving activated charcoal.
Aralen Novel Uses: Which Conditions Have a Clinical Trial Featuring Aralen?
92 active studies are currently underway to assess the effectiveness of Aralen in providing relief for Porphyria Cutanea Tarda, Rheumatoid Arthritis and as a prophylaxis for Malaria.Condition
Clinical Trials
Trial Phases
Lupus Erythematosus, Discoid
2 Actively Recruiting
Phase 2
Actinic prurigo
0 Actively Recruiting
Malaria
0 Actively Recruiting
acute, uncomplicated Malaria
0 Actively Recruiting
Porphyria Cutanea Tarda
0 Actively Recruiting
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Sarcoidosis
16 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Phase 1
prophylaxis of Malaria
0 Actively Recruiting
Extraintestinal Amebiasis
0 Actively Recruiting
Aralen Reviews: What are patients saying about Aralen?
5Patient Review
2/21/2016 I've been taking this since 2000 and it's the only thing that works for me. I tried all of the newer drugs, but I either didn't respond well to them or ended up having an allergic reaction. The manufacturers have stopped making it, so I'm struggling to find it now.
1Patient Review
10/3/2011 In 2005, I developed congestive heart failure from taking aralen. I had been taking it since 1999 for lupus, and my heart problems began shortly thereafter.
Patient Q&A Section about aralen
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Aralen used for?
"Aralen is an antimalarial drug that is used to treat and prevent malaria, as well as treat infections caused by amoebae. The drug is available in generic form."
Answered by AI
What is primaquine used for?
"Primaquine is an antiprotozoal drug used to treat malaria and prevent it from recurring after treatment."
Answered by AI
What is the trade name for chloroquine?
"Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. According to the CDC, chloroquine is effective in preventing malaria in most people who take it."
Answered by AI
What are chloroquine side effects?
"The person may have a headache, feel nauseous, have loss of appetite, diarrhea, or stomach pain, and have a rash or itching."
Answered by AI