Annovera

Birth Control, Acne Vulgaris, Folate supplementation therapy + 5 more
Treatment
1 FDA approval
20 Active Studies for Annovera

What is Annovera

EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the hormone estrogen. It was developed in 1938 and has a higher rate of absorption when taken orally than other forms of estrogen. It is most commonly used in birth control pills, and was approved by the FDA in 1943.
LOESTRIN Fe 1.5/30is the brand name
image of different drug pills on a surface
Annovera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679

Approved as Treatment by the FDA

Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .
Birth Control
Used to treat Contraception in combination with Levonorgestrel

Effectiveness

How Annovera Affects PatientsEthinylestradiol is a form of synthetic estrogen that works by reducing hormones responsible for menstrual cycles and ovulation. It is taken once a day and is typically considered safe, even in the case of overdose. However, patients should be aware of the risk of blood clots that comes with taking this drug.
How Annovera works in the bodyEthinylestradiol is a synthetic estrogen. It is used in combination with other hormones to prevent pregnancy. It works by decreasing the amount of luteinizing hormone, which reduces the chances of a fertilized egg implanting in the uterus. It also thickens cervical mucus to prevent sperm from entering the uterus and increases sex hormone binding globulin. Finally, it decreases bone density.

When to interrupt dosage

The proposed dosage of Annovera is contingent upon the established condition, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The degree of dosage is contingent upon the administration approach detailed in the table beneath.
Condition
Dosage
Administration
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule - Oral, Capsule

Warnings

Annovera has twenty-six contraindications, so it should not be employed for the ailments illustrated in the following table.Annovera Contraindications
Condition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
There are 20 known major drug interactions with Annovera.
Common Annovera Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Annovera Toxicity & Overdose RiskWomen who overdose on birth control may experience bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment for overdose should include monitoring for changes in potassium and sodium levels, as well as signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Annovera Novel Uses: Which Conditions Have a Clinical Trial Featuring Annovera?

38 active trials are currently examining the potential of Annovera for Folate supplementation therapy, Premenstrual Dysphoric Disorder and Menopausal relief.
Condition
Clinical Trials
Trial Phases
Birth Control
33 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting

Annovera Reviews: What are patients saying about Annovera?

5Patient Review
7/24/2020
Annovera for Birth Control
I started using Annovera after seeing an advertisement on YouTube and I'm really happy with it so far. The sex is good and my husband is happy, too. The ring is very small and very soft, so I don't even feel it.
5Patient Review
7/20/2020
Annovera for Birth Control
This treatment is great! It really helped me out.
5Patient Review
11/30/2020
Annovera for Birth Control
I am very pleased with the Annovera ring. I only wish I had known about it sooner! I would recommend it to anyone who is looking for an effective contraception method.
5Patient Review
5/20/2022
Annovera for Birth Control
I had tried oral combined birth control but was getting constant bleeding. This ring is awesome. Skin is good, no mood swings, no weight fluctuations. I felt terribly nauseous for the first week, but it subsided. I strongly recommend this birth control.
5Patient Review
7/4/2020
Annovera for Birth Control
5Patient Review
7/5/2020
Annovera for Birth Control
5Patient Review
7/29/2020
Annovera for Birth Control
I'm really happy with this product. It's amazing.
5Patient Review
4/22/2021
Annovera for Birth Control
I've been using Annovera for 11 months now and I highly recommend it to others. It's an easy ring to take out.
4.7Patient Review
2/13/2022
Annovera for Birth Control
It was tough to find a ring that fit well and didn't have negative side effects, but this one finally did the trick!
4.7Patient Review
5/10/2021
Annovera for Birth Control
At first I was hesitant to use this medication, but my doctor convinced me and now I'm really glad that he did.
3Patient Review
7/18/2020
Annovera for Birth Control
Annovera was a huge help and made life much easier.
2Patient Review
9/6/2021
Annovera for Birth Control
I tried this for almost a full cycle but had to stop because the side effects were too much for me. My depression was worse than it had been in months, and I also experienced severe cramping and bleeding. This might work for some people, but it definitely didn't work for me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about annovera

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Annovera ring?

"Some of the most commonly reported side effects by women taking ANNOVERA in clinical studies were headaches or migraines, nausea or vomiting, fungal infections, abdominal pain, menstrual cramps, vaginal discharge, urinary tract infection, breast tenderness or pain, and irregular bleeding including bleeding between periods."

Answered by AI

What type of birth control is Annovera?

"Annovera is a reusable, non-biodegradable, flexible vaginal system that is placed in the vagina for three weeks followed by one week out of the vagina, at which time women may experience a period (a withdrawal bleed)."

Answered by AI

Does Annovera stop your period?

"If you're using Annovera, you don't have to take it out after three weeks. You can skip a single period by leaving it in, or you can skip multiple periods throughout the year. You can even skip all of your periods for a year by leaving it in continuously."

Answered by AI

Is Annovera the same as NuvaRing?

"Annovera and NuvaRing are similar in that they both contain ethinyl estradiol, but differ in that they have different progestins. Annovera contains segesterone acetate and NuvaRing contains etonogestrel."

Answered by AI

Clinical Trials for Annovera

Have you considered Annovera clinical trials? We made a collection of clinical trials featuring Annovera, we think they might fit your search criteria.
Have you considered Annovera clinical trials? We made a collection of clinical trials featuring Annovera, we think they might fit your search criteria.
Have you considered Annovera clinical trials? We made a collection of clinical trials featuring Annovera, we think they might fit your search criteria.