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LY3214996 + Abemaciclib for Glioblastoma
Study Summary
This trial is testing a new cancer treatment on 50 people with recurrent glioblastoma. The treatment will be given before surgery to remove the tumor.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You have a current and serious bacterial or fungal infection that requires intravenous antibiotics or a detectable viral infection such as HIV or Hepatitis B/C. You don't need to get tested for these infections to join the study.You have already taken medicines like CDK4/6 inhibitors or ERK1/2 inhibitors as part of your treatment.You have taken part in another experimental treatment or received any other intervention within the last 30 days or 5 half-lives of the investigational product, whichever is longer.You can take medication by mouth without difficulty.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Group 1: Arm 1
Frequently Asked Questions
Are participants currently being accepted for this clinical experiment?
"According to the clinicaltrials.gov listing, this investigation is still searching for suitable subjects. This trial was initially announced on July 8th 2020 and updated in March 10th 2022."
How many individuals are presently participating in this clinical research?
"Affirmative. According to the records on clinicaltrials.gov, this medical experiment is actively seeking out participants since it was first posted in July 8th 2020 and last updated at March 10th 2022. 50 patients need to be sourced from three separate research sites."
What symptoms has LY3214996 typically been effective in alleviating?
"LY3214996 is a common intervention for patients at high risk of recurrence, as well as those with advanced hr+her2- breast cancer, endocrine therapy related issues, and other forms of the disease."
What is the ultimate purpose of this experiment?
"According to the study sponsor, Eli Lilly and Company, Phase 0: Pharmacokinetic analysis of cerebrospinal fluid (CSF) will be measured over an 8 hour interval as a primary metric. During this clinical trial other outcomes such as mortality rate, abnormalities per CTCAE grading system, and drug-related toxicity incidence shall also be evaluated."
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