Amlodipine Besylate

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more
Treatment
5 FDA approvals
20 Active Studies for Amlodipine Besylate

What is Amlodipine Besylate

AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and angina. It belongs to a group of drugs called dihydropyridine calcium channel blockers, which are less likely to cause heart depression or abnormal heart rhythms than other calcium channel blockers. It has antioxidant properties and can help produce nitric oxide, which helps relax blood vessels and lower blood pressure. A major benefit of amlodipine is that it can be taken once a day.
Norvascis the brand name
image of different drug pills on a surface
Amlodipine Besylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Vasospastic Angina and Coronary Artery Disease (CAD) .
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Disease
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease
Used to treat angiographically documented disease in combination with Atorvastatin
Angina, Stable
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin

Effectiveness

How Amlodipine Besylate Affects PatientsAmlodipine attaches to cell membranes and slows the flow of calcium, which can reduce blood pressure. This drug works for a long time, so it does not need to be taken as often as other medications. When taken by people with hypertension, it reduces both lying down and standing up blood pressure without significantly changing heart rate or the levels of certain chemicals in the blood. When given to people with angina, it increases how long they can exercise, how long it takes before they experience chest pain, and the time until there is a change on an electrocardiogram. It also decreases how often they experience chest
How Amlodipine Besylate works in the bodyAmlodipine is used to lower blood pressure and treat angina. It works by stopping calcium from entering cells in the heart and blood vessels. This makes the blood vessels wider, reducing the pressure of the blood and easing the workload on the heart. Amlodipine also helps to widen the main arteries and small vessels around the heart to improve blood flow. All of these effects help to reduce the symptoms of angina.

When to interrupt dosage

The amount of Amlodipine Besylate is contingent upon the diagnosed state, such as inadequate reply to diet, High Cardiovascular Risk and Lifestyle Modification. The dosage fluctuates as per the technique of delivery (e.g. Tablet, film coated or Tablet) indicated in the table beneath.
Condition
Dosage
Administration
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Angina, Stable
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Amlodipine Besylate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Amlodipine Besylate.
Common Amlodipine Besylate Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Amlodipine Besylate Toxicity & Overdose RiskThe amount of amlodipine needed to be toxic to mice is 37 mg/kg. Overdosing on amlodipine can cause severe dilation of the blood vessels, leading to a rapid heartbeat and shock, which may be fatal. Studies of the drug in rats and mice have not found any evidence of it causing cancer, gene or chromosomal damage, or decreased fertility. Amlodipine is not recommended for pregnant or nursing women, as the safety of the drug in these cases has not been proven. Nursing mothers should discontinue using amlodipine while breastfeeding.
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Amlodipine Besylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Amlodipine Besylate?

Currently, there are 46 active studies investigating the potential of Amlodipine Besylate to reduce High Cardiovascular Risk, alleviate Vasospastic Angina and manage Coronary Artery Disease (CAD).
Condition
Clinical Trials
Trial Phases
Dyslipidemias
1 Actively Recruiting
Phase 2
Congestive Heart Failure
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
inadequate response to diet
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Hypertensive disease
3 Actively Recruiting
Not Applicable
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Dyslipidemias
0 Actively Recruiting
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Lifestyle Modification
2 Actively Recruiting
Not Applicable
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Artery Disease
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Pharmacotherapy
0 Actively Recruiting

Amlodipine Besylate Reviews: What are patients saying about Amlodipine Besylate?

5Patient Review
9/18/2022
Amlodipine Besylate for High Blood Pressure
I've been on this medication for nearly 30 years and it's by far the best one I've tried. I had zero side effects, which is amazing considering how long I've been on it.
5Patient Review
8/5/2022
Amlodipine Besylate for High Blood Pressure
I was really surprised by how well this worked. My blood pressure dropped 20% with just one 2.5MG tablet once a day. And I didn't experience any negative side effects, which was great.
3.3Patient Review
10/27/2022
Amlodipine Besylate for High Blood Pressure
I'm finding myself more tired than usual since starting this medication. Each day, I've needed to take at least a two hour nap.
3Patient Review
6/30/2022
Amlodipine Besylate for High Blood Pressure
I've been on 2.5 mg of Amlodipine for about two weeks now, and it hasn't been as effective as Lisinopril. Lisinopril caused multiple side effects, so my doctor switched me to Amlodipine. However, I've experienced headaches, chest pain, shoulder pain, fatigue, and a dry cough since starting Amlodipine. I'm not sure if I'll continue with this medication or not.
2.3Patient Review
6/22/2022
Amlodipine Besylate for High Blood Pressure
My blood pressure has been higher than normal for the last few years. I started taking amlodipine and it helped for a while, but then my numbers starting going up again. My doctor added losartan, but now I'm experiencing joint pain in my fingers. I'm hoping this will work soon.
View All Reviews
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Patient Q&A Section about amlodipine besylate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the most common side effect of amlodipine?

"You may have swelling while you're taking amlodipine oral tablets. This was the most common side effect reported in studies of the drug. Swelling from amlodipine oral tablets typically happens in your arms, feet, hands, or legs. Your risk for swelling with amlodipine may increase with higher doses of the drug."

Answered by AI

What are the dangers of taking amlodipine besylate?

"If you have high blood pressure for a long time, it can damage your heart, brain, and kidneys. This can lead to a stroke, heart failure, or kidney failure. High blood pressure also can increase your risk of having a heart attack."

Answered by AI

What is amlodipine besylate given for?

"Amlodipine is used to lower blood pressure, either on its own or with other medications. This can help prevent strokes, heart attacks and kidney problems. Amlodipine belongs to a class of drugs called calcium channel blockers. These work by relaxing blood vessels, so that blood can flow more easily."

Answered by AI

What is the best time to take amlodipine besylate?

"The general recommended dosage for amlodipine is to take it once a day, at any time. It is important to take it at the same time each day to maintain even levels of the drug in your system. Amlodipine can be taken with or without food."

Answered by AI

Clinical Trials for Amlodipine Besylate

Have you considered Amlodipine Besylate clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate, we think they might fit your search criteria.
Have you considered Amlodipine Besylate clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate, we think they might fit your search criteria.
Have you considered Amlodipine Besylate clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate, we think they might fit your search criteria.
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