Aleve Pm

Toothache, Chronic Pain, Migraine + 24 more

Treatment

18 FDA approvals

20 Active Studies for Aleve Pm

Treatment for

Toothache

What is Aleve Pm

Naproxen

The Generic name of this drug

Treatment Summary

Naproxen is a common pain reliever and anti-inflammatory drug. It was first approved for prescription use in 1976 and became available over-the-counter in 1994. It is often used to manage acute pain and pain related to rheumatic diseases, and generally has a good safety record. Naproxen comes in both immediate and delayed release forms, and can be combined with sumatriptan to treat migraines or with esomeprazole to lower the risk of stomach ulcers.

Naprosyn

is the brand name

image of different drug pills on a surface

Aleve Pm Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Naprosyn

Naproxen

1976

1260

Approved as Treatment by the FDA

Naproxen, otherwise known as Naprosyn, is approved by the FDA for 18 uses including Juvenile arthritis and Juvenile Idiopathic Arthritis (JIA) .

Juvenile arthritis

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Juvenile Idiopathic Arthritis (JIA)

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Toothache

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Migraine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Esomeprazole

articular inflammation

Used to treat articular inflammation in combination with Esomeprazole

Inflammation

Used to treat articular inflammation in combination with Esomeprazole

Back

Ankylosing Spondylitis

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Dysmenorrhea

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Headache

Back pain

Ankylosing Spondylitis (AS)

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Menstrual Distress (Dysmenorrhea)

Fever

Acute Coryza

Used to treat Acute Migraine in combination with Sumatriptan

Effectiveness

How Aleve Pm Affects Patients

Naproxen is a type of non-selective NSAID medication used to reduce pain, inflammation, and fever. It works by blocking the production of certain hormones that cause these issues. Although naproxen is effective, it can have negative side effects such as raising blood pressure or increasing the risk of upper gastrointestinal bleeding. This risk is higher if the person is also taking other medications such as corticosteroids or anticoagulants, or has a history of ulcers.

How Aleve Pm works in the body

Naproxen is an NSAID that works by blocking enzymes that produce prostaglandins. Prostaglandins are molecules involved in pain, fever, and inflammation. Naproxen blocks two different kinds of enzymes, called COX-1 and COX-2. The COX-1 enzyme is found in normal tissues like the stomach lining, and blocking this enzyme can cause side effects like gastrointestinal upset. The COX-2 enzyme produces prostaglandins that cause pain, fever, and inflammation, and blocking this enzyme can help reduce these symptoms.

When to interrupt dosage

The recommended dosage of Aleve Pm is contingent upon the diagnosed condition, including Menstrual Distress (Dysmenorrhea), Migraine and Toothache. The amount of dosage is contingent upon the technique of delivery (e.g. Tablet, extended release or Tablet, delayed release) presented in the table below.

Condition

Dosage

Administration

Acute Coryza

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Inflammation

Collagen Diseases

Migraine

Sinusitis

Influenza

Bursitis

Fever

Arthritis, Juvenile

Dysmenorrhea

Spasm

Epilepsy, Post-Traumatic

Back

Primary Dysmenorrhoea

Tendinopathy

Arthritis, Gouty

Rheumatoid Arthritis

Hay Fever

Nasal Congestion

Warnings

Aleve Pm Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Coronary Artery Bypass Grafting

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

There are 20 known major drug interactions with Aleve Pm.

Common Aleve Pm Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The metabolism of Amiodarone can be decreased when combined with Naproxen.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Naproxen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Naproxen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Naproxen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Naproxen.

Aleve Pm Toxicity & Overdose Risk

Naproxen is available over-the-counter, but this increases the risk of someone taking too much and having an overdose. Usually, the effects are mild and include drowsiness, tiredness, stomach pain, nausea and vomiting. There is no specific antidote, but symptoms should go away with proper care. Naproxen should not be taken in late pregnancy as it can cause premature closure of the fetal ductus arteriosus.

image of a doctor in a lab doing drug, clinical research

Aleve Pm Novel Uses: Which Conditions Have a Clinical Trial Featuring Aleve Pm?

635 active clinical trials are currently underway to evaluate the potential of Aleve PM to ameliorate Chronic Pain, Migraine and Juvenile Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Influenza

29 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Postoperative Pain

19 Actively Recruiting

Phase 4, Phase 2, Phase 1, Phase 3, Not Applicable

Chronic Pain

130 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Inflammation

0 Actively Recruiting

Bursitis

0 Actively Recruiting

Tendinopathy

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Juvenile arthritis

8 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Spasm

0 Actively Recruiting

Back

8 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 1

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Collagen Diseases

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Arthritis, Gouty

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Epilepsy, Post-Traumatic

0 Actively Recruiting

Aleve Pm Reviews: What are patients saying about Aleve Pm?

Patient Review

5/4/2016

Aleve Pm for Chronic Trouble Sleeping

I have Fybromyalgia and this product has been a godsend. I can finally get some rest without worrying about my pain levels.

2.7

Patient Review

7/11/2016

Aleve Pm for Chronic Trouble Sleeping

I've taken Aleve pm a few times in the past few months, and each time I wake up feeling like I'm choking. This happens multiple times per night and prevents me from getting any restful sleep.Aleve by itself is great for pain relief, but it doesn't help at all with insomnia.

Patient Review

3/31/2018

Aleve Pm for Chronic Trouble Sleeping

After taking this medication, I was unable to sleep for two hours. The next two hours were incredibly painful, with my muscles feeling like they were going to tear out of my body. I finally got some relief after four more hours but woke up feeling awful.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aleve pm

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Aleve PM to kick in?

"Aleve PM helped me fall asleep without back pain by working quickly, within 30 minutes. This allowed me to feel refreshed for my next shift."

Answered by AI

How many Aleve PM 220 mg can I take?

"Use the medicine every 8 to 12 hours. For the first dose, you can take 2 pills within the first hour. Do not take more than 2 pills in 12 hours, and do not take more than 3 pills in 24 hours."

Answered by AI

What are the side effects of taking Aleve PM every night?

"The following side effects may occur: drowsiness, dizziness, stomach upset, nausea, or blurred vision. If you experience any of these side effects, tell your doctor or pharmacist. Your doctor has decided that the benefits of this medication are greater than the risks of side effects."

Answered by AI

Does Aleve PM make you sleep?

"Aleve PM is for people who occasionally have trouble sleeping because of minor pain. It contains the same pain reliever found in Aleve (naproxen sodium) but also has a sleep aid (diphenhydramine HCl). This way, you can fall asleep and stay asleep for a good night's rest."

Answered by AI

Clinical Trials for Aleve Pm

Have you considered Aleve Pm clinical trials?

We made a collection of clinical trials featuring Aleve Pm, we think they might fit your search criteria.

Have you considered Aleve Pm clinical trials?

We made a collection of clinical trials featuring Aleve Pm, we think they might fit your search criteria.

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+

All Sexes

Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4

Waitlist Available

Has No Placebo

Sunnybrook Health Sciences Centre (+4 Sites)