Acetazolamide Sodium
Familial periodic paralysis, Calorimetry, Indirect, Hypercapnia + 12 more
Treatment
5 FDA approvals
20 Active Studies for Acetazolamide Sodium
Treatment for
Familial periodic paralysis
What is Acetazolamide Sodium
Acetazolamide
The Generic name of this drug
Treatment Summary
Acetazolamide is a medication sometimes used to help treat seizure disorders, particularly absence seizures. It can also be used as an additional treatment for tonic-clonic, myoclonic, and atonic seizures, especially in women whose seizures are triggered by the menstrual cycle. However, the effects of acetazolamide can quickly wear off due to tolerance. The antiepileptic effect of this drug is thought to be due to its ability to inhibit brain carbonic anhydrase, which increases chloride levels in the brain and increases inhibition.
AcetaZOLAMIDE
is the brand name
Acetazolamide Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
AcetaZOLAMIDE
Acetazolamide
1978
96
Approved as Treatment by the FDA
Acetazolamide, commonly known as AcetaZOLAMIDE, is approved by the FDA for 5 uses such as Open Angle Glaucoma (OAG) and Other and unspecified effects of high altitude .
Open Angle Glaucoma (OAG)
Other and unspecified effects of high altitude
Altitude Sickness
Open Angle Glaucoma
nonuveitic secondary glaucoma
Effectiveness
How Acetazolamide Sodium Affects Patients
Acetazolamide is a medicine used to reduce the amount of fluid in the body, treat certain types of seizures, and increase urination. It is not a type of antibiotic, but instead belongs to a group of drugs called sulfonamides. It works differently than other medications and has a unique chemical structure and effect on the body.
How Acetazolamide Sodium works in the body
Acetazolamide works in two main ways. First, it reduces the amount of carbon dioxide in the lungs, which increases the amount of oxygen in your blood. Second, it stops a chemical reaction that helps the body absorb hydrogen ions. This affects the way that salt and water are passed out of your body in urine, making you pass more water than usual.
When to interrupt dosage
The measure of Acetazolamide Sodium is contingent upon the identified disorder, including Inflammation, Tonic - clonic seizures and Metabolic Alkalosis. The dosage amount fluctuates according to the method of delivery (e.g. Injection, powder, lyophilized, for solution - Intravenous or Powder, for solution) specified in the table beneath.
Condition
Dosage
Administration
Respiration stimulated
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Urine alkalinization therapy
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Congestive Heart Failure
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Preoperative
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Metabolic Alkalosis
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Open Angle Glaucoma
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Hypercapnia
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
nonuveitic secondary glaucoma
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Swollen feet or ankles
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Familial periodic paralysis
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Calorimetry, Indirect
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Altitude Sickness
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Kidney Calculi
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
salicylate intoxication
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Edema
, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg
, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule
Warnings
Acetazolamide Sodium Contraindications
Condition
Risk Level
Notes
Acidosis
Do Not Combine
Angle Closure Glaucoma
Do Not Combine
Disease
Do Not Combine
Cirrhosis
Do Not Combine
depressed sodium and/or potassium blood serum levels
Do Not Combine
Glaucoma
Do Not Combine
Sulfonamides
Do Not Combine
Chronic Kidney Disease (CKD)
Do Not Combine
hyperchloremic acidosis
Do Not Combine
Glaucoma
Do Not Combine
Chronic Kidney Disease (CKD)
Do Not Combine
Addison Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Acetazolamide may interact with Pulse Frequency
There are 20 known major drug interactions with Acetazolamide Sodium.
Common Acetazolamide Sodium Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Acetazolamide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Acetazolamide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Acetazolamide.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Acetazolamide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Acetazolamide.
Acetazolamide Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetazolamide Sodium?
76 active studies are currently being conducted to assess the potential of Acetazolamide Sodium to treat Glaucoma, Preoperative Swelling and other related conditions.
Condition
Clinical Trials
Trial Phases
Hypercapnia
0 Actively Recruiting
Familial periodic paralysis
0 Actively Recruiting
Metabolic Alkalosis
0 Actively Recruiting
Edema
0 Actively Recruiting
Preoperative
0 Actively Recruiting
Calorimetry, Indirect
0 Actively Recruiting
Respiration stimulated
0 Actively Recruiting
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
salicylate intoxication
0 Actively Recruiting
nonuveitic secondary glaucoma
0 Actively Recruiting
Urine alkalinization therapy
0 Actively Recruiting
Altitude Sickness
0 Actively Recruiting
Open Angle Glaucoma
10 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Kidney Calculi
0 Actively Recruiting
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Patient Q&A Section about acetazolamide sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does acetazolamide cause hyponatremia?
"Side effects of acetazolamide can include tingling in the hands and feet, tiredness, drowsiness, depression, decreased sex drive, a bitter or metallic taste in the mouth, nausea, vomiting, stomach cramps, diarrhea, dark stool, increased urination, kidney stones, acidosis (too much acid in the blood), and electrolyte changes (low potassium or sodium levels)."
Answered by AI
Does acetazolamide increase sodium?
"Acetazolamide causes an increase in the loss of sodium and potassium ions into the tubular fluid, which causes urine to become more alkaline. However, the hydrogen ions are retained in the plasma, which causes a mild acidosis. However, the drop in the plasma concentration of hydrogen ions stimulates the activity of carbonic anhydrase, which quickly leads to tolerance to the diuretic action of acetazolamide."
Answered by AI
Does acetazolamide lower sodium?
"Acetazolamide inhibits carbonic anhydrase, causing sodium, bicarbonate, and chloride to be excreted rather than reabsorbed. This also leads to the excretion of excess water."
Answered by AI
What is the use of acetazolamide?
"Acetazolamide is a medication used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Acetazolamide works by decreasing the pressure in the eye."
Answered by AI