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What is Ziac
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medication used to treat fluid retention and high blood pressure. It is the most commonly prescribed medication in its category, although it is being replaced by newer medications such as angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. The FDA approved Hydrochlorothiazide in 1959.
Esidrixis the brand name
Ziac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Antihypertensive Treatment and Stroke .Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Effectiveness
How Ziac Affects PatientsHydrochlorothiazide is a drug that helps the body get rid of extra water in the form of urine. It is usually taken in doses of 25-100mg and should be used with caution in those with kidney or liver problems.
How Ziac works in the bodyHydrochlorothiazide enters cells in the distal convoluted tubule of the kidney and is then moved to the lumen of the tubule. Normally, sodium is absorbed by these cells and pumped into the tissue around them, which creates a concentration gradient that helps reabsorb water. Hydrochlorothiazide prevents this process by blocking the absorption of sodium and reducing the concentration gradient. This reduces the amount of water that is reabsorbed.
When to interrupt dosage
Condition
Dosage
Administration
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
hypokalemia with solo treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Ziac has two contraindications, so it ought not to be taken when encountering any of the conditions detailed in the following table.Ziac ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Ziac Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Ziac Toxicity & Overdose RiskThe toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Symptoms of an overdose include low levels of potassium, chlorine, and sodium in the blood, as well as hypotension and difficulty breathing. Treatment includes replacing lost fluids and electrolytes, as well as using oxygen and vasopressors to help with breathing and blood pressure.
Ziac Novel Uses: Which Conditions Have a Clinical Trial Featuring Ziac?
There are 158 active studies examining the potential of Ziac to alleviate Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Antihypertensive Treatment
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
41 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cirrhosis
49 Actively Recruiting
Phase 1, Not Applicable, Phase 4, Phase 3, Phase 2, Early Phase 1
Renal tubular acidosis
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diabetes Insipidus
1 Actively Recruiting
Phase 1
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
hypokalemia with solo treatment
0 Actively Recruiting
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Ziac Reviews: What are patients saying about Ziac?
5Patient Review
8/19/2017 This treatment is effective.
5Patient Review
6/9/20115Patient Review
7/24/20115Patient Review
4/6/2012 1) cough 2) heartburn 3) gaining weight
5Patient Review
10/30/2013 I'm experiencing a lot of fatigue and now have a rash. Not happy with the side effects.
5Patient Review
7/25/2012 I take one pill every day after brushing my teeth. This, in combination with exercise, has helped me lower my blood pressure significantly. My doctor was very impressed with the results after only one visit. I still watch my salt intake and exercise regularly to maintain this health improvement.
5Patient Review
10/12/2011 I'm glad my insurance covers this medication.
5Patient Review
11/7/2012 Though blood pressure has lowered, I have unfortunately experienced more joint pain and dizziness.
4.3Patient Review
5/27/20114.3Patient Review
6/29/20114.3Patient Review
10/13/2014 I was on this medication for 11 years and developed many serious side effects, including a skin condition, shortness of breath, swelling in my feet and legs, and feelings of congestive heart failure. I kept trying to tell the doctors but they brushed me off. Finally, I got a pharmacist's help to wean myself off the drug. It was very difficult and almost killed me.
3.3Patient Review
12/8/2011 I didn't experience any side effects, which is great. And I also didn't have the dry cough that's common with this medication, so that was a plus.
3Patient Review
6/8/20113Patient Review
9/9/2013 This pill has been a miracle for me. I'm 43 years old and I feel great! My blood pressure and heart rate are both lower, and the swelling is under control now.
2.7Patient Review
12/5/2011 This treatment didn't do much for my cough. I'm still hacking away and it's been a week since I started using it.
2.7Patient Review
5/21/2013 I find that this medication gives me a very dry cough.
2.3Patient Review
10/24/2013 I was doing well on Ziac, even the generic Bioprolo 5/6.25 until it was taken off the market. My doctor then doubled my dosage of bisprolo fum tabs to 12.5 because they no longer made the 6.25 version any more. I don't understand why my medication would need to be doubled...
Patient Q&A Section about ziac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Ziac prescribed for?
"This medication is a combination of two drugs that are used to treat high blood pressure, which is also known as hypertension. By lowering high blood pressure, this medication can help to prevent strokes, heart attacks, and kidney problems."
Answered by AI
Is Ziac a water pill?
"Ziac is a combination of two drugs that are used to treat high blood pressure. The first drug is a thiazide diuretic, which helps to remove excess fluid from the body. The second drug is a beta-blocker, which works by blocking the action of certain hormones that can raise blood pressure."
Answered by AI
What class of drug is Ziac?
"Hydrochlorothiazide, the second medication in the combination pill, is a diuretic, which prevents the body from holding on to extra salt and water.
Ziac is a combination pill that contains two different medications. The first medication, bisoprolol, is a beta blocker which slows down the heart. The second medication, hydrochlorothiazide, is a diuretic. Diuretics help the body to get rid of extra salt and water."
Answered by AI
Does bisoprolol make you pee?
"If you take this medicine, you may have to urinate more often. To avoid having trouble sleeping, don't take the medicine too close to bedtime."
Answered by AI