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What is Xarelto
RivaroxabanThe Generic name of this drug
Treatment SummaryRivaroxaban is a blood-thinning medication. It is the first of its kind that can be taken orally and works by stopping the body's natural formation of blood clots. Unlike other anticoagulants, Rivaroxaban does not require regular tests to monitor its effectiveness. However, there is no antidote available if a person experiences excessive bleeding. The 10 mg tablet can be taken without food, while the 15 mg and 20 mg tablets should be taken with food. Rivaroxaban was approved by the FDA in 2011.
Xareltois the brand name
Xarelto Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xarelto
Rivaroxaban
2011
15
Approved as Treatment by the FDA
Rivaroxaban, otherwise called Xarelto, is approved by the FDA for 22 uses like Deep vein thrombosis recurrent and Chronic Coronary Artery Disease .Deep vein thrombosis recurrent
Chronic Coronary Artery Disease
Used to treat Chronic Coronary Artery Disease in combination with Acetylsalicylic acid
Non Valvular Atrial Fibrillation (nv AF)
Prophylaxis of Deep Vein Thrombosis
Recurrent Pulmonary Embolism (Disorder)
Peripheral Arterial Disease (PAD)
Used to treat Peripheral Arterial Disease (PAD) in combination with Acetylsalicylic acid
Deep Vein Thrombosis
Deep Vein Thrombosis
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Acetylsalicylic acid
Cerebrovascular accident prophylaxis
Total Knee Arthroplasty
Arthroplasty
Heart Attack
Used to treat Myocardial Infarction in combination with Acetylsalicylic acid
Disease
Stroke
Used to treat Cerebrovascular Accident in combination with Acetylsalicylic acid
Systemic Embolism
Peripheral Arterial Disease
Used to treat Peripheral Arterial Disease (PAD) in combination with Acetylsalicylic acid
Coronary Artery Disease
Used to treat Chronic Coronary Artery Disease in combination with Acetylsalicylic acid
prophylaxis of systemic embolism
Atrial Fibrillation
Deep Vein Thrombosis
Pulmonary Embolism
Effectiveness
How Xarelto Affects PatientsRivaroxaban is a medication that stops blood from clotting. It works by blocking a protein (called Factor Xa) that helps start the process of forming a blood clot. Rivaroxaban is different from other anticoagulants because it is taken orally, not injected, and it does not need another protein (called antithrombin III) to work. Testing the levels of rivaroxaban in the blood is not recommended as it does not give an accurate measure of how well the drug is working.
How Xarelto works in the bodyRivaroxaban stops the formation of blood clots by blocking a protein called factor Xa from activating. Factor Xa is needed to turn prothrombin into thrombin, which helps form a loose meshwork in the clotting process. Rivaroxaban prevents this process from happening, making it difficult for a clot to form. The effects of rivaroxaban are irreversible.
When to interrupt dosage
Condition
Dosage
Administration
Deep Vein Thrombosis (DVT)
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
prophylaxis of systemic embolism
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Deep Vein Thrombosis
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Cerebrovascular accident prophylaxis
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Total Knee Arthroplasty
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Congenital Heart Defect
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Arthroplasty
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Peripheral Arterial Disease
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Coronary Disease
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Heart Attack
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Pulmonary Embolism
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Fontan Procedure
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Stroke
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Deep Vein Thrombosis
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Coronary Artery Disease
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Major Adverse Cardiovascular Events
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Acute Coryza
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Systemic Embolism
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Prophylaxis of Venous Thromboembolic Events
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Atrial Fibrillation
, 10.0 mg, 15.0 mg, 20.0 mg, 2.5 mg, 5250.0 mg, 2625.0 mg, 1.0 mg/mL, 51.7 mg, 103.4 mg, 155.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Granule, for suspension - Oral, Granule, for suspension, Granule - Oral, Granule
Warnings
Xarelto ContraindicationsCondition
Risk Level
Notes
Hemorrhage
Do Not Combine
Common Xarelto Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Rivaroxaban.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Rivaroxaban.
Anti-inhibitor coagulant complex
Major
The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Rivaroxaban.
Antihemophilic factor (recombinant), PEGylated
Major
The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Rivaroxaban.
Antihemophilic factor human
Major
The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Rivaroxaban.
Xarelto Toxicity & Overdose RiskTaking too much of this drug can cause excessive bleeding. Treatment may include activated charcoal and other measures to help stop the bleeding. If the bleeding does not stop, a doctor may give procoagulants, such as activated prothrombin complex concentrate, prothrombin complex concentrate, or recombinant factor VIIa. People who take this drug may also have a higher chance of post-procedure bleeding compared to those taking enoxaparin.
Xarelto Novel Uses: Which Conditions Have a Clinical Trial Featuring Xarelto?
206 active trials are presently being conducted to assess the effectiveness of Xarelto in Total Knee Replacement, Recurrent Venous Thromboembolism and Deep Vein Thrombosis interventions.Condition
Clinical Trials
Trial Phases
prophylaxis of systemic embolism
0 Actively Recruiting
Cerebrovascular accident prophylaxis
0 Actively Recruiting
Coronary Disease
1 Actively Recruiting
Not Applicable
Deep Vein Thrombosis
0 Actively Recruiting
Deep Vein Thrombosis (DVT)
25 Actively Recruiting
Phase 4, Early Phase 1, Phase 3, Phase 2, Not Applicable
Coronary Artery Disease
0 Actively Recruiting
Arthroplasty
3 Actively Recruiting
Not Applicable
Acute Coryza
0 Actively Recruiting
Pulmonary Embolism
25 Actively Recruiting
Phase 4, Phase 3, Early Phase 1, Not Applicable
Peripheral Arterial Disease
37 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1, Phase 4
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Systemic Embolism
3 Actively Recruiting
Not Applicable
Fontan Procedure
0 Actively Recruiting
Venous Thromboembolism
0 Actively Recruiting
Major Adverse Cardiovascular Events
0 Actively Recruiting
Congenital Heart Defect
35 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
Disease
0 Actively Recruiting
Prophylaxis of Venous Thromboembolic Events
0 Actively Recruiting
Deep Vein Thrombosis
10 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4
Xarelto Reviews: What are patients saying about Xarelto?
5Patient Review
9/6/2022 I haven't had any of the side effects mentioned by other people on this site. I would rather take this medication than risk a blood clot resulting in stroke or death.
5Patient Review
9/13/2019 I had a pulmonary embolism and started this treatment six years ago. I have not experienced any negative side effects from it.
5Patient Review
5/14/2022 I've been using this medication for three months now and I couldn't be happier. No side effects whatsoever.
5Patient Review
11/2/2020 There are no adverse effects to taking this medication. I would recommend doing so at bedtime. Whenever I have cut myself while on this medication, the bleeding has been minimal.
4.3Patient Review
9/3/2021 I've been on Xarelto for half a year now, and it's kept the blood clot in my heart at bay. I haven't had any serious side effects that I know of, though there is an unusual rash on my forearm that won't go away. My doctor suggested a "Watchman" procedure if I want to stop taking this medication, but I'm not sure if that's the best idea.
Patient Q&A Section about xarelto
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the serious side effects of Xarelto?
"The following are symptoms of cervical cancer: back pain, bloody stools, bowel or bladder dysfunction, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing up blood, difficulty with breathing or swallowing, headache, increased menstrual flow or vaginal bleeding."
Answered by AI
What is better eliquis or Xarelto?
"Medication A (apixaban/Eliquis) is better than medication B (rivaroxaban/Xarelto) for stroke prevention in patients with atrial fibrillation, according to a study published in JAMA. Medication A was associated with reduced rates of severe bleeding complications and strokes."
Answered by AI
Why was Xarelto taken off the market?
"Xarelto also has a number of additional side effects, including abdominal bleeding, brain hemorrhage, abnormal liver function and reduced platelet levels. Janssen Pharmaceuticals issued a voluntary recall of 13,500 bottles of Xarelto last October due to a microbial contamination discovered in a sample."
Answered by AI
What is the most common side effect of Xarelto?
"Common side effects of Xarelto include bleeding. Xarelto is an anticoagulant drug that makes it harder for your body to form blood clots, so an increased risk for bleeding is to be expected."
Answered by AI
Why is Xarelto taken at night?
"XARELTO should be taken orally once daily with the evening meal."
Answered by AI
What is Xarelto used for?
"This can lead to blood clots, which can travel to the brain, causing a stroke, or to other parts of the body
XARELTO is a prescription medication used to reduce the risk of stroke and blood clots in adults who have a medical condition called atrial fibrillation."
Answered by AI
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