Upneeq

Nasal Intubation, Rhinorrhea, Rhinitis, Allergic + 10 more

Treatment

3 FDA approvals

20 Active Studies for Upneeq

What is Upneeq

Oxymetazoline

The Generic name of this drug

Treatment Summary

Oxymetazoline is a medicine that stimulates the alpha-adrenergic receptors. It is used in topical and intranasal forms to treat facial redness in adults and nasal and sinus congestion caused by colds, hay fever, and allergies. It can also be used as a regional anesthetic in dentistry and, most recently, was approved as an ophthalmic treatment for ptosis, or drooping eyelids, in adults.

Afrin Original Pump Mist

is the brand name

Upneeq Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Afrin Original Pump Mist

Oxymetazoline

1975

7

Approved as Treatment by the FDA

Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and Obesity .

Anesthesia, Conduction

Used to treat induction of Regional Anesthesia in combination with Tetracaine

Obesity

Used to treat weight 40 kg or more in combination with Tetracaine

Anesthesia, Conduction

Used to treat Regional Anesthesia therapy in combination with Tetracaine

Effectiveness

How Upneeq Affects Patients

Oxymetazoline is a type of drug that works by narrowing the blood vessels and reducing blood flow. It is particularly effective at stimulating two types of adrenergic receptors, the α1- and α2-adrenergic receptors. This drug can be used to relieve nasal congestion and improve airflow in the nose, with effects lasting up to 12 hours. It also has anti-oxidant properties which may protect against tissue damage from inflammation.

How Upneeq works in the body

Oxymetazoline works by targeting certain types of receptors in the body. It stimulates alpha 1A-adrenergic receptors, which can reduce the facial redness associated with rosacea. In blepharoptosis, it stimulates alpha-adrenergic receptors in the Muller muscle, which causes the eyelid to lift up. It is also used in combination with tetracaine to numb areas of the body for dental procedures. Lastly, it helps relieve nasal congestion by constricting blood vessels in the nose, reducing mucosal blood flow and edema.

When to interrupt dosage

The recommended dose of Upneeq is contingent upon the diagnosed condition, such as Regional Anesthesia, weight 40 kg or more and Hay Fever. The amount of dosage is adjusted as per the delivery technique (e.g. Solution - Nasal or Solution) specified in the table below.

Condition

Dosage

Administration

Sinus Congestion

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Postoperative Hemorrhage

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Nasal Intubation

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Rhinorrhea

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Rhinitis, Allergic

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Obesity

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Nasal Congestion

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Acquired Blepharoptosis

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Anesthesia, Conduction

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Rosacea

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Anesthesia, Conduction

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Airway visualization

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

persistent facial erythema

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream - Topical, Cream, Spray - Topical, Solution / drops - Nasal, Kit, Kit - Topical, Jelly, Solution / drops; Spray, Solution / drops; Spray - Nasal, Solution - Ophthalmic, Nasal; Oral, Jelly - Nasal

Warnings

Upneeq has one contraindication and should not be taken concurrently with the conditions noted in the following table.

Upneeq Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Oxymetazoline may interact with Pulse Frequency

There are 20 known major drug interactions with Upneeq.

Common Upneeq Drug Interactions

Drug Name

Risk Level

Description

Antazoline

Major

The absorption of Antazoline can be decreased when combined with Oxymetazoline.

Azelastine

Major

The absorption of Azelastine can be decreased when combined with Oxymetazoline.

Beclomethasone dipropionate

Major

The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.

Betamethasone

Major

The absorption of Betamethasone can be decreased when combined with Oxymetazoline.

Budesonide

Major

The absorption of Budesonide can be decreased when combined with Oxymetazoline.

Upneeq Toxicity & Overdose Risk

In rats, the toxic dose of oxymetazoline is 680 micrograms per kilogram when taken orally and 1630 micrograms per kilogram when administered subcutaneously. For mice, the toxic dose is 4700 micrograms per kilogram when taken orally, 48 milligrams per kilogram when taken intraperitoneally, and 34 milligrams per kilogram when administered subcutaneously. Overdosing on oxymetazoline can lead to dizziness, chest pain, headaches, heart attack, stroke, vision problems, irregular heartbeat, high or low blood pressure, drowsiness, pupil dilation,

image of a doctor in a lab doing drug, clinical research

Upneeq Novel Uses: Which Conditions Have a Clinical Trial Featuring Upneeq?

Thirteen active clinical trials are currently underway to assess the utility of Upneeq in providing Nasal Congestion relief, Ear structure Anesthesia, and Conduction Anesthesia.

Condition

Clinical Trials

Trial Phases

Postoperative Hemorrhage

7 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

persistent facial erythema

0 Actively Recruiting

Rhinorrhea

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

Rosacea

0 Actively Recruiting

Acquired Blepharoptosis

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

Airway visualization

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

Nasal Intubation

0 Actively Recruiting

Obesity

631 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1, Phase 3

Sinus Congestion

0 Actively Recruiting

Upneeq Reviews: What are patients saying about Upneeq?

5

Patient Review

8/11/2022

Upneeq for acquired drooping of the upper eyelid

Upneeq completely impressed me. I could immediately tell the difference between my treated and untreated eye, and now use it for special occasions. I highly recommend this product to anyone looking for a quick beauty boost with zero side effects!

5

Patient Review

8/10/2022

Upneeq for acquired drooping of the upper eyelid

I used Upneeq for a special occasion and I was really happy with the results! I got so many compliments from people who know me well, and many asked if I'd had surgery to lift my eyes. Of course, I hadn't - Upneeq is just that good. Now, it's part of my daily routine and I couldn't be without it.

5

Patient Review

7/19/2022

Upneeq for acquired drooping of the upper eyelid

I adore Upneeq! It's been such a gamechanger for me, both in terms of how I look and feel.

5

Patient Review

8/24/2022

Upneeq for acquired drooping of the upper eyelid

UPNEEQ is perfect for special occasions when you want your eyes to look extra bright and awake. It takes effect within five minutes and lasts for six hours with no noticeable side effects.

5

Patient Review

11/7/2022

Upneeq for acquired drooping of the upper eyelid

This product has really changed things for me. I used to be very self-conscious about my droopy eyelids, but Upneeq gives me a subtle yet noticeable lift that feels great. Plus, it doesn't have any negative side effects that I've experienced. Would definitely recommend it to others!

5

Patient Review

6/14/2022

Upneeq for acquired drooping of the upper eyelid

These worked great for me! I'm 52 and they made my eyes look wide awake.

5

Patient Review

6/21/2022

Upneeq for acquired drooping of the upper eyelid

This is by far the best cosmetic product I've used in a long time. It gave me a great eyelid lift with no side effects whatsoever.

4.7

Patient Review

6/6/2022

Upneeq for acquired drooping of the upper eyelid

I really enjoy this product, but there are a few things to be aware of. Firstly, it can be tough to open the packaging; I use small scissors. Secondly, if you use it every day it can get costly; I save money by only using it for parties or other social functions. The upside is that the lid lift is great and my eyes look incredibly white. It also lasts for six hours without any discomfort or side effects. Additionally, the onset is very fast – within 5-10 minutes – and improves my field of vision.

3.3

Patient Review

6/16/2022

Upneeq for acquired drooping of the upper eyelid

I got droopy eyelids after Botox, and this helped to fix that problem to some degree. Although, I have high blood pressure which made me feel really jittery after taking it. So be careful if you have any heart conditions.

3.3

Patient Review

11/6/2022

Upneeq for acquired drooping of the upper eyelid

Though this did alleviate the ptosis in my right eye, it made my left appear smaller by comparison. Additionally, it's been almost a day and my pupil is still very dilated. I also experienced issues with seeing halos around lights while driving at night.

2

Patient Review

8/9/2022

Upneeq for acquired drooping of the upper eyelid

The eyedrops helped for a short while, but then the rebound effect was really terrible. They also made me feel weird and my tinnitus has gotten much worse since using them.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about upneeq

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Upneeq prescription only?

"This product requires a prescription. Please consult your doctor for more information. Find a doctor in your area!"

Answered by AI

What is Upneeq used for?

"This drug is used to treat blepharoptosis, a condition that causes the eyelid to droop. It is classified as an alpha agonist. Oxymetazoline works by shortening and tightening the eyelid muscle."

Answered by AI

How long can you use Upneeq?

"Another factor to consider is the price. A monthly prescription for Upneeq costs around $105 a month, which adds up to $1,200 a year. Dr.Jun says that depending on one's budget, it might make more financial sense to opt for eyelid surgery—it costs around $5,000 and lasts about 20 years."

Answered by AI

What does Upneeq cost?

"How much is Upneeq? Upneeq is $105 for a 30-day supply."

Answered by AI

Clinical Trials for Upneeq

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Alison B Hamilton, PhD MPH

Image of Brigham and Womens Hospital in Boston, United States.

Chia Seeds for Breastfeeding

18 - 45
All Sexes
Boston, MA

The investigators' over-arching hypothesis is that mechanical and compositional properties of chia seeds supplemented during lactation diminish obesity-induced intestinal inflammation and barrier dysfunction. The investigators hypothesize these changes will result in: 1) reduced maternal systemic inflammation (serum CRP and IL-6) and increased gut microbial diversity and richness, 2) reduced HM fat and inflammatory markers, metrics the research team have demonstrated differ in tandem with maternal metabolic health and 3) improved infant growth/body composition. To test these hypotheses, investigators will evaluate chia seed supplementation during lactation in a 6wk multi-site pilot RCT (Aim 1) and through translational studies using human enteroids (Aim 2).

Waitlist Available
Has No Placebo

Brigham and Womens Hospital (+1 Sites)

David A Fields, Phd

Have you considered Upneeq clinical trials?

We made a collection of clinical trials featuring Upneeq, we think they might fit your search criteria.
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Image of Public Health Research Center: Clinical Exercise Research Center in Columbia, United States.

Pistachio Snacking for Obesity

25 - 45
All Sexes
Columbia, SC

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Recruiting
Has No Placebo

Public Health Research Center: Clinical Exercise Research Center

Katie R Hirsch, PhD

Image of People Science in Los Angeles, United States.

CLB101 for Gut Health in Obesity

18 - 65
All Sexes
Los Angeles, CA

Anaerostipes caccae CLB101TM️ is a next-generation probiotic isolated from healthy humans. It was shown to be in decreased abundance in people with protein-based food sensitivities/allergies. CLB101TM️ is different from most commercially available probiotics in that it directly produces butyrate. Butyrate is a naturally occurring small molecule found in the gut of healthy individuals, and it has been shown to provide clinical benefits including strengthening the gut lining, providing immune health, and supporting a balanced microbiome. The rationale for developing CLB101TM️ is to provide a probiotic that generates butyrate in the targeted intestinal locations where it can optimally benefit cells that line the gut.

Waitlist Available
Paid Trial

People Science

Naoh Craft, MD

ClostraBio Inc.

Have you considered Upneeq clinical trials?

We made a collection of clinical trials featuring Upneeq, we think they might fit your search criteria.
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Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of Local Restaurant Site in Bryan, United States.

Menu Labeling for Healthy Habits and Diet

18+
All Sexes
Bryan, TX

This study evaluates the impact of culturally tailored menu labeling interventions on psychosocial factors and ordering behavior among customers in two independently owned Hispanic restaurants in East-Central Texas. Participants will be exposed to one of three sequential menu conditions at each restaurant: (1) a standard menu without nutrition information, (2) a paper menu with bilingual nutrition labels, or (3) a digital menu app enhanced with Augmented Reality (AR) and Artificial Intelligence (AI) providing interactive nutrition guidance. The study will assess whether menu formats influence nutrition literacy, decision-making confidence, self-efficacy, attitudes, behavioral intentions, and actual ordering behavior. Data will be collected through surveys, purchase receipts, and app interaction logs.

Recruiting
Has No Placebo

Local Restaurant Site

Hyunjung Lee, PhD

Have you considered Upneeq clinical trials?

We made a collection of clinical trials featuring Upneeq, we think they might fit your search criteria.
Go to Trials