Upneeq

Nasal Intubation, Rhinorrhea, acute Rhinitis + 10 more
Treatment
3 FDA approvals
4 Active Studies for Upneeq

What is Upneeq

OxymetazolineThe Generic name of this drug
Treatment SummaryOxymetazoline is a medicine that stimulates the alpha-adrenergic receptors. It is used in topical and intranasal forms to treat facial redness in adults and nasal and sinus congestion caused by colds, hay fever, and allergies. It can also be used as a regional anesthetic in dentistry and, most recently, was approved as an ophthalmic treatment for ptosis, or drooping eyelids, in adults.
Afrin Original Pump Mistis the brand name
Upneeq Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afrin Original Pump Mist
Oxymetazoline
1975
7

Approved as Treatment by the FDA

Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and weight 40 kg or more .
Anesthesia, Conduction
Used to treat induction of Regional Anesthesia in combination with Tetracaine
weight 40 kg or more
Used to treat weight 40 kg or more in combination with Tetracaine
Anesthesia, Conduction
Used to treat Regional Anesthesia therapy in combination with Tetracaine

Effectiveness

How Upneeq Affects PatientsOxymetazoline is a type of drug that works by narrowing the blood vessels and reducing blood flow. It is particularly effective at stimulating two types of adrenergic receptors, the α1- and α2-adrenergic receptors. This drug can be used to relieve nasal congestion and improve airflow in the nose, with effects lasting up to 12 hours. It also has anti-oxidant properties which may protect against tissue damage from inflammation.
How Upneeq works in the bodyOxymetazoline works by targeting certain types of receptors in the body. It stimulates alpha 1A-adrenergic receptors, which can reduce the facial redness associated with rosacea. In blepharoptosis, it stimulates alpha-adrenergic receptors in the Muller muscle, which causes the eyelid to lift up. It is also used in combination with tetracaine to numb areas of the body for dental procedures. Lastly, it helps relieve nasal congestion by constricting blood vessels in the nose, reducing mucosal blood flow and edema.

When to interrupt dosage

The recommended dose of Upneeq is contingent upon the diagnosed condition, such as Regional Anesthesia, weight 40 kg or more and Hay Fever. The amount of dosage is adjusted as per the delivery technique (e.g. Solution - Nasal or Solution) specified in the table below.
Condition
Dosage
Administration
persistent facial erythema
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Postoperative Hemorrhages
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Nasal Intubation
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Sinus Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Rhinorrhea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Acquired Blepharoptosis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
weight 40 kg or more
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
acute Rhinitis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Nasal Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Rosacea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Airway visualization
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal

Warnings

Upneeq has one contraindication and should not be taken concurrently with the conditions noted in the following table.Upneeq Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxymetazoline may interact with Pulse Frequency
There are 20 known major drug interactions with Upneeq.
Common Upneeq Drug Interactions
Drug Name
Risk Level
Description
Antazoline
Major
The absorption of Antazoline can be decreased when combined with Oxymetazoline.
Azelastine
Major
The absorption of Azelastine can be decreased when combined with Oxymetazoline.
Beclomethasone dipropionate
Major
The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.
Betamethasone
Major
The absorption of Betamethasone can be decreased when combined with Oxymetazoline.
Budesonide
Major
The absorption of Budesonide can be decreased when combined with Oxymetazoline.
Upneeq Toxicity & Overdose RiskIn rats, the toxic dose of oxymetazoline is 680 micrograms per kilogram when taken orally and 1630 micrograms per kilogram when administered subcutaneously. For mice, the toxic dose is 4700 micrograms per kilogram when taken orally, 48 milligrams per kilogram when taken intraperitoneally, and 34 milligrams per kilogram when administered subcutaneously. Overdosing on oxymetazoline can lead to dizziness, chest pain, headaches, heart attack, stroke, vision problems, irregular heartbeat, high or low blood pressure, drowsiness, pupil dilation,
image of a doctor in a lab doing drug, clinical research

Upneeq Novel Uses: Which Conditions Have a Clinical Trial Featuring Upneeq?

Thirteen active clinical trials are currently underway to assess the utility of Upneeq in providing Nasal Congestion relief, Ear structure Anesthesia, and Conduction Anesthesia.
Condition
Clinical Trials
Trial Phases
persistent facial erythema
0 Actively Recruiting
Rhinorrhea
0 Actively Recruiting
Rosacea
0 Actively Recruiting
Nasal Intubation
0 Actively Recruiting
weight 40 kg or more
0 Actively Recruiting
Nasal Congestion
1 Actively Recruiting
Not Applicable
Anesthesia, Conduction
0 Actively Recruiting
Sinus Congestion
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
acute Rhinitis
0 Actively Recruiting
Airway visualization
0 Actively Recruiting
Postoperative Hemorrhages
3 Actively Recruiting
Not Applicable, Phase 1
Acquired Blepharoptosis
0 Actively Recruiting

Upneeq Reviews: What are patients saying about Upneeq?

5Patient Review
8/11/2022
Upneeq for acquired drooping of the upper eyelid
Upneeq completely impressed me. I could immediately tell the difference between my treated and untreated eye, and now use it for special occasions. I highly recommend this product to anyone looking for a quick beauty boost with zero side effects!
5Patient Review
8/10/2022
Upneeq for acquired drooping of the upper eyelid
I used Upneeq for a special occasion and I was really happy with the results! I got so many compliments from people who know me well, and many asked if I'd had surgery to lift my eyes. Of course, I hadn't - Upneeq is just that good. Now, it's part of my daily routine and I couldn't be without it.
5Patient Review
7/19/2022
Upneeq for acquired drooping of the upper eyelid
I adore Upneeq! It's been such a gamechanger for me, both in terms of how I look and feel.
5Patient Review
8/24/2022
Upneeq for acquired drooping of the upper eyelid
UPNEEQ is perfect for special occasions when you want your eyes to look extra bright and awake. It takes effect within five minutes and lasts for six hours with no noticeable side effects.
5Patient Review
11/7/2022
Upneeq for acquired drooping of the upper eyelid
This product has really changed things for me. I used to be very self-conscious about my droopy eyelids, but Upneeq gives me a subtle yet noticeable lift that feels great. Plus, it doesn't have any negative side effects that I've experienced. Would definitely recommend it to others!
5Patient Review
6/14/2022
Upneeq for acquired drooping of the upper eyelid
These worked great for me! I'm 52 and they made my eyes look wide awake.
5Patient Review
6/21/2022
Upneeq for acquired drooping of the upper eyelid
This is by far the best cosmetic product I've used in a long time. It gave me a great eyelid lift with no side effects whatsoever.
4.7Patient Review
6/6/2022
Upneeq for acquired drooping of the upper eyelid
I really enjoy this product, but there are a few things to be aware of. Firstly, it can be tough to open the packaging; I use small scissors. Secondly, if you use it every day it can get costly; I save money by only using it for parties or other social functions. The upside is that the lid lift is great and my eyes look incredibly white. It also lasts for six hours without any discomfort or side effects. Additionally, the onset is very fast – within 5-10 minutes – and improves my field of vision.
3.3Patient Review
6/16/2022
Upneeq for acquired drooping of the upper eyelid
I got droopy eyelids after Botox, and this helped to fix that problem to some degree. Although, I have high blood pressure which made me feel really jittery after taking it. So be careful if you have any heart conditions.
3.3Patient Review
11/6/2022
Upneeq for acquired drooping of the upper eyelid
Though this did alleviate the ptosis in my right eye, it made my left appear smaller by comparison. Additionally, it's been almost a day and my pupil is still very dilated. I also experienced issues with seeing halos around lights while driving at night.
2Patient Review
8/9/2022
Upneeq for acquired drooping of the upper eyelid
The eyedrops helped for a short while, but then the rebound effect was really terrible. They also made me feel weird and my tinnitus has gotten much worse since using them.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about upneeq

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Upneeq prescription only?

"This product requires a prescription. Please consult your doctor for more information. Find a doctor in your area!"

Answered by AI

What is Upneeq used for?

"This drug is used to treat blepharoptosis, a condition that causes the eyelid to droop. It is classified as an alpha agonist. Oxymetazoline works by shortening and tightening the eyelid muscle."

Answered by AI

How long can you use Upneeq?

"Another factor to consider is the price. A monthly prescription for Upneeq costs around $105 a month, which adds up to $1,200 a year. Dr.Jun says that depending on one's budget, it might make more financial sense to opt for eyelid surgery—it costs around $5,000 and lasts about 20 years."

Answered by AI

What does Upneeq cost?

"How much is Upneeq? Upneeq is $105 for a 30-day supply."

Answered by AI

Clinical Trials for Upneeq