L-Isoleucine for Obesity
(ISOLATE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
Who Is on the Research Team?
Jean Fry, PhD
Principal Investigator
University of Kentucky
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Run-in
Participants transition from a typical American diet to a plant-based diet low in isoleucine
Treatment
Participants receive a low-isoleucine diet with either isoleucine supplementation or placebo
Follow-up
Participants are monitored for changes in insulin sensitivity and other metabolic markers
What Are the Treatments Tested in This Trial?
Interventions
- L-Isoleucine
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will be randomized to receive low-isoleucine diet and isoleucine supplement
Participants will be randomized to receive low-isoleucine diet and placebo supplement
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jean L. Fry
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator
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