Chia Seeds for Breastfeeding
What You Need to Know Before You Apply
What is the purpose of this trial?
The investigators' over-arching hypothesis is that mechanical and compositional properties of chia seeds supplemented during lactation diminish obesity-induced intestinal inflammation and barrier dysfunction. The investigators hypothesize these changes will result in: 1) reduced maternal systemic inflammation (serum CRP and IL-6) and increased gut microbial diversity and richness, 2) reduced HM fat and inflammatory markers, metrics the research team have demonstrated differ in tandem with maternal metabolic health and 3) improved infant growth/body composition. To test these hypotheses, investigators will evaluate chia seed supplementation during lactation in a 6wk multi-site pilot RCT (Aim 1) and through translational studies using human enteroids (Aim 2).
Who Is on the Research Team?
David A Fields, Phd
Principal Investigator
University of Oklahoma
Kathy Burge, Phd
Principal Investigator
University of Oklahoma Health Sciences
Paige H Berger, Phd, RDN
Principal Investigator
Brigham and Women's Hospital
Are You a Good Fit for This Trial?
This trial is for mothers aged 18-45 with a pre-pregnancy BMI over 25, who had a vaginal delivery of one baby and plan to breastfeed for at least three months. They shouldn't have taken antibiotics within a week before visits or chia seed supplements during pregnancy.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive chia seed supplementation during lactation to evaluate its impact on metabolic health, milk composition, and infant growth
Follow-up
Participants are monitored for changes in breast milk composition and maternal serum levels post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- Chia Seeds
Trial Overview
The study tests if adding chia seeds to the diet of breastfeeding mothers can reduce obesity-related inflammation in their gut and improve the composition of their breast milk, potentially benefiting infant growth and body composition.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
This group will receive the food-based intervention
This arm is the control arm that will not receive food-based dietary intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Oklahoma
Lead Sponsor
Presbyterian Health Foundation
Collaborator
Brigham and Women's Hospital
Collaborator
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