MACI vs Microfracture for Knee Cartilage Injury
(PEAK Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of patients aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is MACI safe for treating knee cartilage injuries?
MACI (Matrix-induced Autologous Chondrocyte Implantation) has been approved by the U.S. Food and Drug Administration for treating knee cartilage defects, indicating it meets safety standards. Research shows patients generally do well after the procedure, with improvements lasting up to 5 years.12345
How does the MACI treatment differ from other treatments for knee cartilage injury?
MACI (Matrix-induced Autologous Chondrocyte Implantation) is unique because it uses a patient's own cultured cartilage cells on a collagen membrane to repair knee cartilage, potentially offering better surgical handling and patient comfort compared to microfracture, which involves creating small fractures in the bone to stimulate cartilage growth.12678
What data supports the effectiveness of the treatment MACI for knee cartilage injury?
MACI (Matrix-induced Autologous Chondrocyte Implantation) has been approved by the US FDA for treating knee cartilage defects, and it is known to improve surgical handling and patient comfort. It has been used since 2000 for repairing knee cartilage, and studies suggest it may allow for faster rehabilitation compared to traditional methods.12378
Who Is on the Research Team?
Jonathan Hopper
Principal Investigator
Vericel Corporation
Are You a Good Fit for This Trial?
This trial is for young people aged 10-17 with knee problems like cartilage damage or osteochondritis. They should have a specific type of severe cartilage injury that can be treated surgically, and their knee must be stable. It's not for those who've had recent surgery on the same knee, are pregnant, have certain allergies, or joint conditions like rheumatoid arthritis.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either MACI or microfracture treatment
Rehabilitation
Participants follow a recommended postoperative rehabilitation program
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- MACI
- Microfracture
MACI is already approved in United States, European Union for the following indications:
- Symptomatic articular cartilage defects of the knee
- Symptomatic articular cartilage defects of the knee
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vericel Corporation
Lead Sponsor