Pistachio Snacking for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
Who Is on the Research Team?
Katie R Hirsch, PhD
Principal Investigator
University of South Carolina
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 25-45 who are overweight or obese (BMI=25.0-34.9), don't exercise much, eat a varied diet, and have poor sleep quality. It's not for those with metabolic, cardiovascular, sleep disorders or any condition affecting metabolism or ability to do the exercise test.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo two conditions: four days of pistachio snacking and four days of normal dietary habits, with metabolic measurements taken pre- and post-intervention.
Follow-up
Participants are monitored for changes in metabolic flexibility, diet quality, sleep characteristics, and physical activity post-treatment.
What Are the Treatments Tested in This Trial?
Interventions
- Pistachio
Trial Overview
The study tests if eating pistachios affects how the body uses energy at rest, during exercise, and after exercising in overweight/obese individuals. Participants alternate between four days of pistachio snacking and their regular diet while researchers measure changes in metabolism and other health aspects like sleep and hormones.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Four days of pistachio snacking, to be consumed mid-morning (1oz; 9-11am), mid-afternoon (1oz; 2-4pm), and pre-sleep (0.5 oz; within 1hr of bedtime), while otherwise maintaining normal dietary habits. An addition snack will be consumed post-exercise (0.5oz).
Maintain normal dietary habits for four days.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of South Carolina
Lead Sponsor
American Pistachio Growers
Collaborator
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