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What is Uniretic
MoexiprilThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a drug used to treat high blood pressure and fluid retention. It is the most widely prescribed thiazide diuretic and is often used in combination with other medications such as angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. Hydrochlorothiazide was approved by the FDA in 1959 and is still widely used today, although it has been decreasing in popularity due to the emergence of newer medications.
Univascis the brand name
Uniretic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Univasc
Moexipril
1995
42
Approved as Treatment by the FDA
Moexipril, commonly known as Univasc, is approved by the FDA for 1 uses like Hypertensive disease .Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Effectiveness
How Uniretic Affects PatientsHydrochlorothiazide works by stopping the kidneys from taking in too much water and salt. The amount of this drug taken can vary depending on the person and usually ranges from 25-100mg. Those with reduced kidney or liver function should be careful when taking this medication.
How Uniretic works in the bodyHydrochlorothiazide works by blocking sodium from being reabsorbed into cells in the distal convoluted tubule of the kidneys. Normally, sodium is reabsorbed from the tubule and deposited into the basolateral interstitium, which creates a concentration gradient that draws water back into the cells. Hydrochlorothiazide prevents this process by blocking the sodium-chloride symporter, which decreases the concentration gradient and reduces the reabsorption of water.
When to interrupt dosage
The amount of Uniretic is contingent on the identified condition, including Antepartum magnesium sulfate protection, blood pressure inadequately managed with monotherapy and antihypertensives. The dosage fluctuates as per the mode of delivery (e.g. Tablet, coated - Oral or Oral) delineated in the table beneath.Condition
Dosage
Administration
Hypertensive disease
, 7.5 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated
Warnings
Uniretic has two counter-indications, and so should not be taken when present with any of the conditions listed in the following table.Uniretic ContraindicationsCondition
Risk Level
Notes
Angioedema
Do Not Combine
Type 2 Diabetes
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Uniretic Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Moexipril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Moexipril is combined with Azathioprine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Moexipril is combined with Hydroxyzine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Moexipril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Moexipril.
Uniretic Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Those who overdose may experience low potassium, chloride, and sodium levels. Treatment for an overdose should include fluids, electrolytes, and supportive care such as vasopressors to regulate blood pressure and oxygen for respiratory issues.
Uniretic Novel Uses: Which Conditions Have a Clinical Trial Featuring Uniretic?
Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Uniretic Reviews: What are patients saying about Uniretic?
5Patient Review
11/4/20094.3Patient Review
3/11/20094Patient Review
12/1/2010 I sometimes feel nauseous after taking this medication.
3.7Patient Review
3/13/2009Patient Q&A Section about uniretic
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Univasc used for?
"Univasc is a prescription medication used to address the symptoms of hypertension, and can be used either alone or in conjunction with other drugs. It belongs to a class of drugs referred to as ACE inhibitors."
Answered by AI
What does HCTZ stand for?
"Hydrochlorothiazide is a diuretic that helps reduce water retention by increasing urine output. It is only available with a doctor's prescription."
Answered by AI
Is Moexipril a diuretic?
"Before taking moexipril, it is important to tell your doctor about all other medications you are taking, including over the counter drugs and supplements. You should also share any other medical conditions you have. Diuretic therapy should be discontinued, if possible, 2 to 3 days before starting moexipril. If blood pressure remains uncontrolled with this drug alone, diuretic therapy may be restarted."
Answered by AI
When is the best time to take Moexipril?
"Store the medicine in a closed container at room temperature
Dosing. The dose of this medicine will differ among patients. ... , Missed Dose. If you miss a dose of this medicine, try to take it as soon as you remember. ... , Storage. Keep the medicine in a closed container at room temperature"
Answered by AI