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What is Tymlos
AbaloparatideThe Generic name of this drug
Treatment SummaryAbaloparatide (known as Tymlos) is a synthetic peptide used to treat postmenopausal women with osteoporosis who are at high risk for fracture. Abaloparatide stimulates bone formation while limiting bone resorption, which could make it more convenient and easier to take than other bone-strengthening drugs. The FDA approved Abaloparatide in 2017.
Tymlosis the brand name
Tymlos Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tymlos
Abaloparatide
2017
1
Approved as Treatment by the FDA
Abaloparatide, also known as Tymlos, is approved by the FDA for 2 uses which include Postmenopause and high risk of fracture Osteoporosis .Postmenopause
high risk of fracture Osteoporosis
Effectiveness
How Tymlos Affects PatientsAbaloparatide (BA058) is a drug being studied for its ability to treat osteoporosis in postmenopausal women. It is based on human parathyroid hormone-related protein (hPTHrP), which helps create new bone. Unlike parathyroid hormone, which mostly affects calcium and bone breakdown, PTHrP encourages the formation of new bone. Clinical trials have shown that higher doses of this drug result in increased bone mineral density and more bone formation.
How Tymlos works in the bodyAbaloparatide works by attaching to a particular type of receptor in target cells, which then triggers a signaling pathway. This pathway, known as cAMP and ERK-1/2, causes the cell to respond in a more short-term way, than other receptors.
When to interrupt dosage
The suggested portion of Tymlos is contingent upon the identified condition. The measure of dosage fluctuates, as per the delivery technique (e.g. Injection, solution or Injection, solution - Subcutaneous) specified in the table beneath.Condition
Dosage
Administration
Postmenopause
, 2.0 mg/mL
, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
high risk of fracture Osteoporosis
, 2.0 mg/mL
, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
Warnings
Tymlos has one contraindication, and so should not be employed when having any of the circumstances stated in the following table.There are 20 known major drug interactions with Tymlos.Common Tymlos Drug Interactions
Drug Name
Risk Level
Description
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Abaloparatide.
Carbutamide
Minor
The therapeutic efficacy of Carbutamide can be decreased when used in combination with Abaloparatide.
Chlorpropamide
Minor
The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Abaloparatide.
Glibornuride
Minor
The therapeutic efficacy of Glibornuride can be decreased when used in combination with Abaloparatide.
Gliclazide
Minor
The therapeutic efficacy of Gliclazide can be decreased when used in combination with Abaloparatide.
Tymlos Toxicity & Overdose RiskAbaloparatide may cause an increase in osteosarcoma (bone cancer) in rats, though this has not been proven to happen in humans. People with Paget's disease, open growth plates, or other skeletal malignancies should avoid this treatment. Abaloparatide may also lead to high levels of calcium in the blood, so people with hyperthyroidism or hypercalcemia should not take it. Overdosing on abaloparatide may cause high calcium levels, nausea, vomiting, dizziness, fast heart rate, low blood pressure when standing, and headaches. There is no known
Tymlos Novel Uses: Which Conditions Have a Clinical Trial Featuring Tymlos?
Currently, five active trials are exploring the possibility of utilizing Tymlos to reduce the risk of fracture in Osteoporosis patients.Condition
Clinical Trials
Trial Phases
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
high risk of fracture Osteoporosis
0 Actively Recruiting
Tymlos Reviews: What are patients saying about Tymlos?
5Patient Review
4/27/2021 I was diagnosed with severe osteoporosis in my spine about 4 years ago. Started Tymlos 2 years ago at a -3.5 in spine. After 2 years and tolerating the medication very well I am thrilled to say my t-score has improved to -2.1!! No more osteoporosis and a 15% improvement in bone density.
5Patient Review
7/24/2019 I have not experienced any negative side effects from this treatment, which is amazing given how easy it is to use.
4.7Patient Review
2/5/2020 I find that my heart rate increases by about two hours when I use this medication, but if I drink a lot of water before using it, that helps. Prior to taking Tymlos, I had two fractures and was still having microfractures, which caused me a lot of pain. But within a month of taking Tymlos, I felt stronger and much less pain—more like my old self again.
4Patient Review
6/28/2022 I've only been using Tymlos for a month, but it's been really great so far! I haven't had any negative side effects, except for a brief headache in the morning that goes away after 30 minutes or so. I make sure to stretch and drink lots of water every day, which may help reduce the chances of other side effects. The daily injection can be a bit annoying, but it's not too bad. Overall, I'm very happy with this treatment.
3Patient Review
7/10/2022 I've started taking Tymlos, but I'm struggling with the injection site they suggest. After gaining a lot of weight while pregnant with triplets, I needed surgery to repair my stomach muscles and remove excess skin. Now that I've lost all the weight, my stomach is very muscular but it's also covered in scar tissue and stretch marks. Is there an alternative location where I can inject the Tymlos?
2.7Patient Review
1/27/2019 I have to space out my doses of this medication because it raises my heart rate too much if I take it too frequently. Additionally, I don't enjoy the sensation of giving myself a shot every day.
2.3Patient Review
9/28/2019 Though easy to use, I haven't been using it long enough to tell if it's effective. It has caused side effects like rapid heart rate, exhaustion, and ringing in my ears that make me feel bad for the rest of the day. Hopefully it will work though.
2.3Patient Review
1/1/2020 I frequently have episodes of feeling very sad during the day, and I also suffer from constant joint pain and easy bruising.
2.3Patient Review
7/15/2021 I experienced some nausea and heart palpitations while taking the medicine. I also felt "growing" pains at different times during the first year. My dexa scores remained relatively unchanged, with one score being slightly worse (-.1). I was hopeful that this treatment would increase my bone mass, but unfortunately it did not.
2.3Patient Review
2/27/2020 It's easy to administer, but I don't see why it gives me such bad chest tightening according to the list of side effects. All side effects only last an hour, though, so I give myself a shot an hour before bed. So far, so good.
1Patient Review
4/26/2019 Unfortunately, this drug caused my elderly mother a lot of pain. She experienced jaw and arm pain, flushing and heat in her face, and dizziness that would last for an hour or more after the shot. Her blood pressure is now also very unpredictable and can be dangerously high on some days.
Patient Q&A Section about tymlos
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is TYMLOS safer than Forteo?
"Tymlos is promoted as being a better version of Forteo with a 43% reduction in relative risk of nonvertebral fractures. However, relative risk can be an inaccurately high statistic. The truth is that for both drugs, there was only a 2-4% reduction in the absolute risk of non vertebral fractures."
Answered by AI
How long do you take TYMLOS for?
"Tymlos is only recommended for two years of use, after which its effectiveness decreases and side effects increase. Patients are supposed to follow up Tymlos treatment by using bisphosphonates for several years to maintain bone density gains."
Answered by AI
What are the side effects of the drug TYMLOS?
"High calcium levels in urine (hypercalciuria) can cause symptoms such as dizziness, headache, abdominal pain, and vertigo."
Answered by AI
Is Tymlos the same as Prolia?
"The drug Tymlos contains the active ingredient abaloparatide, while Prolia contains denosumab. These drugs work differently, belonging to different medication classes."
Answered by AI
What kind of drug is TYMLOS?
"TYMLOS is a prescription medicine used to prevent fractures in postmenopausal women with thinning and weakening bones, as well as to treat osteoporosis in postmenopausal women who are at high risk for bone fractures."
Answered by AI
What is the side effects of Tymlos?
"High levels of calcium in the urine (hypercalciuria) can cause dizziness, nausea, headache, palpitations, fatigue, upper abdominal pain, and a spinning sensation (vertigo)."
Answered by AI
Is Tymlos safer than Forteo?
"Tymlos promises to be a more effective version of Forteo, with a 43% reduction in the relative risk of non-vertebral fractures. However, relative risk can be a misleadingly high statistic. In reality, both drugs only offer a 2-4% reduction in the absolute risk of non-vertebral fractures."
Answered by AI
Does Tymlos increase bone density?
"Women with T-scores of -2.5 or lower have osteoporosis. Femoral neck (upper thighbone): -2.6. Women with T-scores of -2.5 or lower have osteoporosis.
At the start of the trial, the average T-score for the women was -2.9 in the lumbar spine (lower back) and -2.6 in the femoral neck (upper thighbone). A T-score of -2.5 or lower indicates osteoporosis. The trial showed that, compared to the placebo group, the group of women taking TYMLOS had significant increases in bone mineral density in both the spine and hip."
Answered by AI