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What is Truvada
Tenofovir disoproxilThe Generic name of this drug
Treatment SummaryTenofovir disoproxil fumarate, sold under the brand name Viread, is a medication used in combination with other drugs to treat HIV infection and Hepatitis B. It belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). Tenofovir disoproxil was approved by the FDA in 2001.
Vireadis the brand name
Truvada Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viread
Tenofovir disoproxil
2001
154
Effectiveness
How Truvada Affects PatientsTenofovir is used to prevent viral DNA chain elongation in HIV-1 and Hepatitis B infections. Studies have shown it to be effective in laboratory and clinical settings against these viruses, with a 50% effective concentration ranging from 0.04 μM to 8.5 μM. When taken with other drugs (like nucleoside reverse transcriptase inhibitors and protease inhibitors) it has been found to have an additive or synergistic effect. In cell cultures, Tenofovir has demonstrated antiviral activity against HIV-1.
How Truvada works in the bodyTenofovir is an antiretroviral medication used to treat HIV. It works by blocking the enzyme needed for the virus to replicate, which helps lower the amount of virus present in the body. Tenofovir is changed in the body to an active form that is then transformed into an even stronger form called tenofovir diphosphate. This molecule binds to the virus and stops it from making new copies of itself, eventually killing it. In rare cases, HIV can become resistant to tenofovir, developing a mutation that makes it harder for the drug to work.
When to interrupt dosage
The prescribed dosage of Truvada is predicated on the established condition, including Anti-Retroviral Agents, High Risk Patients and Chronic Hepatitis B. The measure is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated) featured in the table beneath.Condition
Dosage
Administration
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Chronic Hepatitis B Infection
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
virologically-suppressed
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weight at least 35 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weigh >40 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Antiretroviral Therapy
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Warnings
There are 20 known major drug interactions with Truvada.Common Truvada Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tenofovir disoproxil is combined with Neomycin.
Tenofovir
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir alafenamide.
Abacavir
Minor
Tenofovir disoproxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Tenofovir disoproxil may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Truvada Toxicity & Overdose RiskThe Centers for Disease Control and Prevention recommends that HIV-1-infected mothers not breastfeed their infants to prevent postnatal transmission of HIV-1. Mothers should not breastfeed if they are taking tenofovir disoproxil. Long-term studies of tenofovir disoproxil in mice and rats have shown liver adenomas in female mice at a dose 16 times higher than the human dose, while the rat study showed no carcinogenic findings with a dose up to 5 times the human dose. Tenofovir disoproxil is a pregnancy Category B drug, meaning reproduction studies in
Truvada Novel Uses: Which Conditions Have a Clinical Trial Featuring Truvada?
46 active trials are being conducted to investigate the possible applications of Truvada to substitute the existing antiretroviral treatment regimen of select adult patients with virologically suppressed HIV1 RNA (<50 copies/mL), Chronic Hepatitis B and HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
0 Actively Recruiting
virologically-suppressed
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
weigh >40 kg
0 Actively Recruiting
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
0 Actively Recruiting
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Truvada Reviews: What are patients saying about Truvada?
5Patient Review
7/2/2013 I started taking Truvada and Isentress four days ago with zero side effects. This is the first time I've ever taken HIV medication, and so far I haven't noticed any changes in my energy, ability to sleep, or mood. Fingers crossed that this continues and I'll update when my levels are rechecked.
5Patient Review
11/14/2014 I've been on this medication for six months to help with vomiting and appetite loss. It's also increased my anxiety levels, but overall it's been good. The only problem is that it doesn't play well with the pills I take for epilepsy.
5Patient Review
7/6/2013 In the year that I've been taking Truvada and Isentress, I've seen great results. My viral load is undetectable and my CD4 count has increased from 50 to 326. Additionally, I've never experienced any negative side effects. This medication is easy to take and I have a great doctor.
5Patient Review
12/28/2013 So far, I'm really pleased with this medication. I haven't experienced any negative side effects yet; however, I have had a few issues with constipation and itchiness.
5Patient Review
9/14/2014 I take this drug alongside isentress and have been doing so since October 2009 with no issues whatsoever. In fact, my viral load has been undetectable since I started this treatment regimen.
5Patient Review
11/15/2019 I've been taking Truvada for 16 years now and it's been great. I highly recommend it to anyone looking for an easy way to take their medication once a day.
4.7Patient Review
2/25/2014 I've been taking Truvada with Viramune for over fifteen years now with great success; my viral load has been undetectable the entire time. Recently, there have been some concerns raised about phosphate levels in kidneys and I will have to monitor that closely from now on (RPB test).
4.3Patient Review
11/6/2015 One of the unfortunate side effects I experienced was weight gain; however, the benefits of this treatment definitely outweighed that for me.
4.3Patient Review
2/22/2014 I've only been taking Truvada for a short while as a preventative measure, but I haven't noticed any significant issues yet. As far as I can tell, my body is tolerating it well. Only time will tell if it's truly effective.
3.3Patient Review
5/30/2013 Truvada is a great medicine except in my very special case it gives me a lot of gas in my stomach and also I have developed a hughe belly full of grease (lypodistrophia), it seems most of my body grease accumulates around my abdominal area, which is uncomfortable.
2.7Patient Review
8/12/2013 I was recently exposed to the virus and, per my doctor's orders, started taking issentress with truvada. Two weeks in, I've experienced severe vomiting and a loss of appetite along with depressed mood. The treatment is expensive and will last for 28 days. In two months, I'll have to get tested again to see if it worked.
1.3Patient Review
11/18/2017 I tried Truvada for PreP under my doctor's supervision and had a horrible allergic reaction both times. My groin and right buttock felt a burning sensation that only went away after discontinuing the medicine.
1Patient Review
5/17/2018 I was already struggling with emphysema when I started taking Truvada, and had to discontinue use after just ten days. This is because I didn't realize I was having an allergic reaction the entire time; if I had known, I could have avoided major respiratory problems. So, if you have any preexisting respiratory issues, be wary of this medication.
1Patient Review
11/15/2018 The side effects of this treatment are very real and potentially dangerous. After only one year of taking Truvada, I was hospitalized for acute kidney injury. My bone density was also classified as osteoporosis at only 36 years old. This medication is especially dangerous when mixed with alcohol; even casual drinkers on Truvada could find themselves in serious risk of kidney damage. Be careful of the promises made about this carefree lifestyle--you may end up on dialysis as a result.
1Patient Review
10/4/2016 Unfortunately, I had to stop taking this medication after just five days due to some really unpleasant side effects. These included headaches, dizziness, difficulty concentrating, and severe body aches.
1Patient Review
12/2/2019 After being on this medicine for 8 months, I developed a severe sore throat which made it impossible to eat or drink for an entire week. I had to be hospitalized due to the intense pain. Even now, two weeks later, I'm still experiencing symptoms. We believe the Truvada caused my body to overreact to a simple virus.
1Patient Review
11/25/2018 This drug ruined my sense of taste and smell after only about a month and a half. I stopped taking it as soon as this happened, but even two months later there's been no improvement.
Patient Q&A Section about truvada
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Truvada?
"The two drugs that make up Truvada, emtricitabine and tenofovir disoproxil fumarate, can cause a range of side effects, the most common of which are headaches, rashes, nausea, vomiting, and weight loss. However, there are also a number of rare but potentially serious side effects associated with the drug, including kidney and liver problems, bone loss, potentially fatal lactic acidosis, and immune reconstitution syndrome."
Answered by AI
How much does Truvada cost a month?
"A month's worth of Truvada will set you back nearly $2,000 without insurance, though a generic version can be had for only $30-$60 per month. If you have private health insurance, Medicare, or Medicaid, though, the cost of the drug should be covered under your plan. Additionally, by law private insurers are not allowed to charge copayments for the drug."
Answered by AI
When should I take Truvada?
"In order to use Prep on-demand, an individual must take 2 pills 2-24 hours before any possible sexual exposure to HIV. They must then continue to take 1 pill each day until 2 days after their last possible sexual exposure. The only PrEP medication that is approved for on-demand use is Truvada."
Answered by AI
What Truvada is used for?
"Truvada is used to treat human immunodeficiency virus (HIV) and hepatitis b virus infection and is now also being used to prevent HIV infection. This prevention is called “pre-exposure prophylaxis” or “Prep”."
Answered by AI
What is Truvada drug used for?
"Truvada is a medication used to treat human immunodeficiency virus (HIV) and hepatitis b virus infection. It is now being used to prevent HIV infection. When taken to prevent HIV infection, it is referred to as "pre-exposure prophylaxis" or "Prep"."
Answered by AI