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What is Trihexyphenidyl Hydrochloride
TrihexyphenidylThe Generic name of this drug
Treatment SummaryTrihexyphenidyl is a drug used to treat Parkinson’s disease and other movement disorders caused by taking certain medications. It was discovered in 1949 and is rarely used today due to its significant side effects. It has been mostly replaced by medications like levodopa. Trihexyphenidyl was approved by the FDA in 1949.
Trihexyphenidyl Hydrochlorideis the brand name
Trihexyphenidyl Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trihexyphenidyl Hydrochloride
Trihexyphenidyl
1987
71
Approved as Treatment by the FDA
Trihexyphenidyl, also known as Trihexyphenidyl Hydrochloride, is approved by the FDA for 11 uses which include Idiopathic Parkinson's Disease and Extrapyramidal disorder .Idiopathic Parkinson's Disease
Extrapyramidal disorder
Helps manage Extrapyramidal disorder
arteriosclerotic Parkinsonism
Parkinson Disease
Extrapyramidal symptoms caused by thioxanthenes
Helps manage Extrapyramidal symptoms caused by thioxanthenes
Extrapyramidal symptoms caused by dibenzoxazepines
Helps manage Extrapyramidal symptoms caused by dibenzoxazepines
phenothiazine
Helps manage Extrapyramidal symptoms caused by phenothiazines
Basal Ganglia Diseases
Helps manage Extrapyramidal disorder
Butyrophenones
Helps manage Extrapyramidal symptoms caused by butyrophenones
Parkinsonism post encephalitic
Arteriosclerosis
Effectiveness
How Trihexyphenidyl Hydrochloride Affects PatientsTrihexyphenidyl is used to treat Parkinson's Disease, or to reduce certain effects of medicine on the body. It only needs to be taken occasionally, not every day, and is generally safe to take in large doses. Those taking this medication should have their eye pressure monitored and be aware of the risk of excessive sweating and heat stroke.
How Trihexyphenidyl Hydrochloride works in the bodyTrihexyphenidyl works by blocking receptors in the brain, called muscarinic acetylcholine receptors. These receptors are responsible for sending signals that affect movement. Blocking these receptors helps to reduce the symptoms associated with Parkinson's disease or other movement disorders. Trihexyphenidyl may also increase dopamine release, which helps to further improve movement. The exact way this drug works is not yet fully understood.
When to interrupt dosage
The prescribed amount of Trihexyphenidyl Hydrochloride is contingent upon the determined condition, comprising phenothiazine, Extrapyramidal symptoms induced by dibenzoxazepines and Butyrophenones. The quantity of dosage relies on the mode of administration (e.g. Tablet or Tablet - Oral) indicated in the table underneath.Condition
Dosage
Administration
Basal Ganglia Diseases
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by dibenzoxazepines
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by thioxanthenes
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Arteriosclerosis
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Butyrophenones
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
phenothiazine
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Parkinson Disease
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Parkinsonism post encephalitic
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Warnings
Trihexyphenidyl Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Trihexyphenidyl may interact with Pulse Frequency
Common Trihexyphenidyl Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Trihexyphenidyl is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Ipratropium.
Trihexyphenidyl Hydrochloride Toxicity & Overdose RiskSymptoms of trihexyphenidyl overdose include a dry mouth, no sweating, dilated pupils, nausea, vomiting, fast heartbeat, high fever, reduced digestive activity, difficulty or inability to urinate, rash, confusion, restlessness, poor coordination, paranoia, delirium, hallucinations, coma, trouble breathing, and circulatory failure. These symptoms can be treated with supportive care such as maintaining a clear airway and using a medication called physostigmine. If left untreated, an overdoes of trihexyphenidyl can be fatal, particularly in children.
Trihexyphenidyl Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Trihexyphenidyl Hydrochloride?
At present, 8 active trials are assessing the utility of Trihexyphenidyl Hydrochloride in providing relief from Extrapyramidal symptoms caused by thioxanthenes, encephalitic Parkinsonism and dibenzoxazepine induced Extrapyramidal symptoms.Condition
Clinical Trials
Trial Phases
Arteriosclerosis
6 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Parkinsonism post encephalitic
0 Actively Recruiting
Extrapyramidal symptoms caused by dibenzoxazepines
0 Actively Recruiting
Butyrophenones
0 Actively Recruiting
Basal Ganglia Diseases
0 Actively Recruiting
Extrapyramidal symptoms caused by thioxanthenes
0 Actively Recruiting
phenothiazine
0 Actively Recruiting
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable
Trihexyphenidyl Hydrochloride Reviews: What are patients saying about Trihexyphenidyl Hydrochloride?
5Patient Review
3/30/2019 This drug stops my tremors which is amazing. The only downside is that it causes a really dry mouth and I have no appetite. Consequently, I've lost 8 pounds since starting the medication 3 months ago.
5Patient Review
1/7/20104.3Patient Review
3/15/2013 I'm curious about the name of the drug I'm taking. I have the generic version, but it would be nice to know what exactly I'm consuming.
4.3Patient Review
11/8/20094Patient Review
3/15/2010 I started this medication recently and it's already helping my essential tremor. I'm optimistic that it will help stop the shaking completely.
Patient Q&A Section about trihexyphenidyl hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of trihexyphenidyl?
"Abdominal or stomach cramps or pain, delusions of persecution, mistrust, suspiciousness, or combativeness, excessive dryness of the mouth, nausea or vomiting, seeing, hearing, or feeling things that are not there, skin rash, stomach pain, swollen, painful, or tender lymph glands on the side of the face or neck."
Answered by AI
Is trihexyphenidyl a sedative?
"Although ARTANE is not classified as a controlled substance, it is possible that it will be abused because it has stimulant and euphoric properties."
Answered by AI
What does trihexyphenidyl do to the brain?
"Trihexyphenidyl helps to control symptoms of Parkinson's disease by blocking the receptors for acetylcholine. This restores the balance of acetylcholine and dopamine in the brain."
Answered by AI
What is trihexyphenidyl Hydrochloride used for?
"Trihexyphenidyl is a medication used to treat the symptoms of Parkinson's disease, such as difficulties with movement, muscle control, and balance. It is also used to control extrapyramidal symptoms, such as tremor, slurred speech, caused by certain medications."
Answered by AI
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