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What is Trelegy Ellipta
Fluticasone furoateThe Generic name of this drug
Treatment SummaryFluticasone furoate is a synthetic steroid medication used for treating inflammation. It is available as an inhaler and nasal spray and was first approved by the FDA in 2007.
Veramystis the brand name
Trelegy Ellipta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Veramyst
Fluticasone furoate
2007
22
Approved as Treatment by the FDA
Fluticasone furoate, otherwise known as Veramyst, is approved by the FDA for 2 uses which include Chronic Obstructive Pulmonary Disease and Asthma .Chronic Obstructive Pulmonary Disease
Used to treat Chronic Obstructive Pulmonary Disease (COPD) in combination with Umeclidinium
Asthma
Used to treat Asthma in combination with Umeclidinium
Effectiveness
How Trelegy Ellipta Affects PatientsFluticasone furoate has been shown to activate certain hormones and inhibit certain chemicals when tested in a laboratory setting. This drug has been found to reduce eosinophilia (a type of white blood cell) in the lungs of rats.
How Trelegy Ellipta works in the bodyFluticasone furoate works to reduce inflammation in the body. In tests, it has been shown to activate certain receptors in the body, as well as inhibit certain proteins. This prevents the body from producing substances that cause inflammation.
When to interrupt dosage
The prescribed dosage of Trelegy Ellipta is contingent upon the recognized condition, including Sinusitis, Sinusitis and Perennial Allergic Rhinitis (PAR). The amount of dosage is contingent upon the technique of delivery (e.g. Respiratory (inhalation) or Powder - Respiratory (inhalation)) outlined in the table beneath.Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.0275 mg, 0.1 mg, 0.2 mg, 0.0275 mg/spray, 0.05 mg, 0.092 mg, 0.184 mg, 0.1 mg/pump actuation, 0.2 mg/pump actuation, 0.0275 mg/pump actuation
, Nasal, Spray, metered - Nasal, Spray, metered, Respiratory (inhalation), Powder - Respiratory (inhalation), Powder, Intrasinal, Spray, suspension, Spray, suspension - Intrasinal, Powder, metered - Respiratory (inhalation), Powder, metered
Asthma
, 0.0275 mg, 0.1 mg, 0.2 mg, 0.0275 mg/spray, 0.05 mg, 0.092 mg, 0.184 mg, 0.1 mg/pump actuation, 0.2 mg/pump actuation, 0.0275 mg/pump actuation
, Nasal, Spray, metered - Nasal, Spray, metered, Respiratory (inhalation), Powder - Respiratory (inhalation), Powder, Intrasinal, Spray, suspension, Spray, suspension - Intrasinal, Powder, metered - Respiratory (inhalation), Powder, metered
Seasonal Allergies
, 0.0275 mg, 0.1 mg, 0.2 mg, 0.0275 mg/spray, 0.05 mg, 0.092 mg, 0.184 mg, 0.1 mg/pump actuation, 0.2 mg/pump actuation, 0.0275 mg/pump actuation
, Nasal, Spray, metered - Nasal, Spray, metered, Respiratory (inhalation), Powder - Respiratory (inhalation), Powder, Intrasinal, Spray, suspension, Spray, suspension - Intrasinal, Powder, metered - Respiratory (inhalation), Powder, metered
Perennial Allergy
, 0.0275 mg, 0.1 mg, 0.2 mg, 0.0275 mg/spray, 0.05 mg, 0.092 mg, 0.184 mg, 0.1 mg/pump actuation, 0.2 mg/pump actuation, 0.0275 mg/pump actuation
, Nasal, Spray, metered - Nasal, Spray, metered, Respiratory (inhalation), Powder - Respiratory (inhalation), Powder, Intrasinal, Spray, suspension, Spray, suspension - Intrasinal, Powder, metered - Respiratory (inhalation), Powder, metered
Warnings
Trelegy Ellipta has seven contraindications and should not be combined with the conditions provided in the following table.Trelegy Ellipta ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Fluticasone Furoate may interact with Pulse Frequency
Asthma Acute
Do Not Combine
primary treatment of status asthmaticus
Do Not Combine
Status Asthmaticus
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fluticasone Furoate may interact with Pulse Frequency
Common Trelegy Ellipta Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Fluticasone furoate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Fluticasone furoate.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Acteoside.
Aldesleukin
Major
The therapeutic efficacy of Aldesleukin can be decreased when used in combination with Fluticasone furoate.
Trelegy Ellipta Toxicity & Overdose RiskTaking fluticasone furoate through the nose may lead to a decrease in the body's adrenal hormones or a longer than usual heartbeat. No dose adjustments are needed for those with kidney problems, but those with liver problems should use caution. Fluticasone has not been linked to cancer, mutations, or infertility. There is not much data on how it affects pregnant women or babies, though animal studies have shown that it can cause birth defects and low adrenal hormones in offspring. Children should be given the lowest dose possible and monitored for any growth delays. Elderly patients should also be monitored closely as they may need a different
Trelegy Ellipta Novel Uses: Which Conditions Have a Clinical Trial Featuring Trelegy Ellipta?
252 active clinical trials are examining the potential of Trelegy Ellipta in alleviating Sinusitis, Chronic Obstructive Pulmonary Disease (COPD) and Asthma.Condition
Clinical Trials
Trial Phases
Seasonal Allergies
0 Actively Recruiting
Perennial Allergy
0 Actively Recruiting
Chronic Obstructive Pulmonary Disease
99 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Trelegy Ellipta Reviews: What are patients saying about Trelegy Ellipta?
5Patient Review
5/7/2022 Trelegy has been a godsend for my stage 4 COPD. It's prevented exacerbations and flare-ups since I started using it four months ago. The only side effect I've noticed is some gunk around my eyes in the morning, but that's nothing compared to how well this medication works. Be sure to rinse your mouth out after use or you'll get thrush, though. Overall, managing COPD is a lot easier with Trelegy.
5Patient Review
4/7/2022 I had been taking Spiriva, but it wasn't very effective. Trelegy has given me my life back. Recently I was on vacation and did a lot of walking without needing a wheelchair or stops to catch my breath. It's wonderful. Thanks GSK!
5Patient Review
2/28/2021 I was prescribed Trelegy after Symbicort wasn't helping. This was all after Covid Double Pneumonia
5Patient Review
11/26/2021 Trelegy has been an absolute godsend. I never smoked, but severe asthma starting when I was four years old led to lung damage as the years went by. Trelegy is the best thing that's ever happened to me in terms of managing my condition.
4.7Patient Review
7/2/2022 Advair was my maintenance medication for many years, but it gradually lost its effectiveness. However, the first day after using Trelegy, I found that I didn't need to use my rescue inhaler as often. I'm very pleased with this product and haven't experienced any negative side effects.
3.3Patient Review
1/6/2022 Though this treatment helped my copd for a little while, I found that after 6 or 8 hours I was right back to feeling short of breath and wheezing. This is supposed to be a once-a-day medication, but I had to use my nebulizer and emergency inhaler the rest of the day.
3Patient Review
1/30/2022 I unfortunately experienced some intense side effects after taking this medication. Bladder pain and uncontrolled urination were the main two issues I had.
2.3Patient Review
8/15/2022 I find that all breathing aids provide me with temporary relief at best, and often leave me feeling more congested than before. At $472, this is an ineffective and overpriced medication.
2Patient Review
7/22/2022 Within two days of taking this medication, my left parotid gland (responsible for producing saliva) began to swell. I'm not sure if the powder from the drug caused a blockage that led to the swelling.
1.7Patient Review
9/29/2022 I got sick after using this treatment for only eleven days out of the fourteen day sample. I had the flu for two weeks and then developed thrush. I still don't feel back to normal even a month later.
Patient Q&A Section about trelegy ellipta
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How much does Trelegy cost per month?
"62.3% of TRELEGY prescriptions fall under $50 per month, with the average prescription costing $178 per month. The amount an individual pays is based on the coverage provided by their prescription drug benefit plan."
Answered by AI
What are the side effects of trilogy?
"If you have a fungal infection in your mouth or throat, you may be at risk for developing pneumonia. If you have a weakened immune system, you may be more likely to get infections. If you have reduced adrenal function, you may experience sudden breathing problems after inhaling TRELEGY. If you experience serious allergic reactions, you should seek medical attention immediately."
Answered by AI
Is Trelegy Ellipta a steroid inhaler?
"The long term use of inhaled steroids can lead to weight gain by causing an increase in the production of cortisol. Cortisol is a hormone which can effect your metabolism and too much of it can lead to weight gain."
Answered by AI