Torisel

Kidney Neoplasms
Treatment
2 FDA approvals
16 Active Studies for Torisel

What is Torisel

TemsirolimusThe Generic name of this drug
Treatment SummaryTemsirolimus, sold under the brand name Torisel, is an medication used to treat kidney cancer. It was developed by Wyeth Pharmaceuticals and approved by the FDA in 2007 and the European Medicines Agency in November of the same year.
Toriselis the brand name
image of different drug pills on a surface
Torisel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Torisel
Temsirolimus
2007
5

Approved as Treatment by the FDA

Temsirolimus, otherwise called Torisel, is approved by the FDA for 2 uses including Advanced Renal Cell Carcinoma (aRCC) and Kidney Neoplasms .
Advanced Renal Cell Carcinoma (aRCC)
Kidney Neoplasms

Effectiveness

How Torisel works in the bodyTemsirolimus stops cell division by blocking a protein called mTOR. This protein helps control cell division and when it is blocked, cells can't divide. Temsirolimus also blocks two other proteins, p70S6k and S6 ribosomal protein, which are part of the PI3 Kinase/AKT pathway. Finally, it reduces the levels of two substances called hypoxia-inducible factors (HIF-1 and HIF-2 alpha) and a protein responsible for blood vessel growth (vascular endothelial growth factor).

When to interrupt dosage

The suggested measure of Torisel is contingent upon the diagnosed circumstance. The dosage likewise changes as indicated by the approach of delivery featured in the table beneath.
Condition
Dosage
Administration
Kidney Neoplasms
, 30.0 mg, 25.0 mg/mL
Intravenous, , Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Kit - Intravenous

Warnings

Torisel has one contraindication and should not be utilized while enduring the conditions laid out in the subsequent table.Torisel Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Torisel.
Common Torisel Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Temsirolimus.
Abetimus
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with Acteoside.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Temsirolimus.
Torisel Toxicity & Overdose RiskTemsirolimus can be given to cancer patients in doses of up to 220mg/m2. However, higher doses can increase the risk of serious problems such as blood clots, punctured intestines, lung disease, seizures, and mental health issues.
image of a doctor in a lab doing drug, clinical research

Torisel Novel Uses: Which Conditions Have a Clinical Trial Featuring Torisel?

15 active trials are being conducted to analyze the potential of Torisel to treat Advanced Renal Cell Carcinoma (aRCC).
Condition
Clinical Trials
Trial Phases
Kidney Neoplasms
16 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1

Torisel Reviews: What are patients saying about Torisel?

4.7Patient Review
2/6/2008
Torisel for Cancer Involving the Kidney Cells
I was diagnosed with renal cell carcinoma three years ago and had one kidney removed. I've been on Torisel for three months now, and it has effectively stopped the growth of the tumor and even caused a slight reduction in the active area. The side effects are definitely worth it considering what could happen if I wasn't taking this medication.
4.7Patient Review
2/22/2009
Torisel for Cancer Involving the Kidney Cells
Torisel has been a godsend. I've been taking it for nine months with few negative side effects. My tumors have stopped growing, and I'm feeling much better overall.
4.7Patient Review
12/31/2007
Torisel for Cancer Involving the Kidney Cells
Torisel has been great for me. I haven't experienced too many side effects, and my tumors have stayed the same size according to my CT scan.
4Patient Review
2/2/2009
Torisel for Cancer Involving the Kidney Cells
So far, I've had good results with this treatment. My tumors were growing and now they're stable. I don't have any new ones either. The worst side effect is the fatigue after taking Benedryl as a pre-medication.
4Patient Review
12/4/2008
Torisel for Cancer Involving the Kidney Cells
I've completed nine rounds of this treatment and the only notable side effect has been a change in taste. As for efficacy, my most recent scan showed no change in cancer size.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about torisel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Torisel administered?

"Use an infusion pump to deliver TORISEL intravenously over 30-60 minutes once a week."

Answered by AI

Is temsirolimus a chemotherapy?

"The drug Temsirolimus is also known by the brand name Torisel. Your healthcare professional may use the brand name when referencing the generic drug."

Answered by AI

How is temsirolimus administered?

"Temsirolimus is a prescription medication used to treat a certain type of kidney cancer. It comes as a solution that is injected into a vein over 30-60 minutes. Temsirolimus is usually given once a week by a doctor or nurse in a doctor's office or infusion center."

Answered by AI

What is Torisel used for?

"Torisel is a cancer medicine that slows the growth and spread of cancer cells in the body. It is used to treat renal cell carcinoma, a type of cancer that affects the kidneys. Torisel may also be used for other purposes not listed in this medication guide."

Answered by AI

Clinical Trials for Torisel

Have you considered Torisel clinical trials? We made a collection of clinical trials featuring Torisel, we think they might fit your search criteria.
Have you considered Torisel clinical trials? We made a collection of clinical trials featuring Torisel, we think they might fit your search criteria.
Have you considered Torisel clinical trials? We made a collection of clinical trials featuring Torisel, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top