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What is Telmisartan And Hydrochlorothiazide
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryTelmisartan is a medication used to treat high blood pressure. It belongs to a group of drugs called angiotensin II receptor blockers (ARBs) that work by blocking the action of the hormone angiotensin II. Telmisartan may also have beneficial metabolic effects due to its ability to act as a PPAR-gamma agonist.
Esidrixis the brand name
Telmisartan And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and Left Ventricular Hypertrophy .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Effectiveness
How Telmisartan And Hydrochlorothiazide Affects PatientsTelmisartan is a type of drug that stops the hormone angiotensin II from working. Angiotensin II affects blood pressure by narrowing blood vessels and making the heart work harder. Telmisartan blocks these effects, which helps lower blood pressure. Telmisartan may also have other beneficial effects on metabolism, such as reducing inflammation. Studies are being done to see if this is true.
How Telmisartan And Hydrochlorothiazide works in the bodyTelmisartan works by blocking a hormone called angiotensin II from binding to receptors in the body. Angiotensin II causes blood vessels to tighten, raising blood pressure. By blocking it, telmisartan reduces blood pressure by decreasing blood vessel tightness. Additionally, telmisartan may help with diabetes by activating a protein called PPARγ, which helps with metabolic functions.
When to interrupt dosage
The recommended measure of Telmisartan And Hydrochlorothiazide is contingent upon the diagnosed condition, for example, inability to take ACE inhibitors, Hypertensive disease and Diabetic Nephropathy. The amount of dosage can be found in the table below, contingent upon the administration approach (e.g. Tablet - Oral or Tablet, multilayer).Condition
Dosage
Administration
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Telmisartan And Hydrochlorothiazide has one contraindication, so it should not be employed concurrently with any of the conditions named in the following table.Telmisartan And Hydrochlorothiazide ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Telmisartan And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Telmisartan And Hydrochlorothiazide Toxicity & Overdose RiskThe lowest toxic dose of telmisartan in rats is 150-200 mg/kg in males and 200-250 mg/kg in females. Even when given a dose as high as 2000 mg/kg, no deaths or changes have been reported in rats or dogs. A human overdose on telmisartan may cause low blood pressure, dizziness, and rapid heartbeat, while a slower heartbeat can also occur due to stimulation of the vagus nerve.
Telmisartan And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Telmisartan And Hydrochlorothiazide?
328 active clinical trials are currently taking place to assess the utility of Telmisartan And Hydrochlorothiazide in providing adequate blood pressure control for individuals who cannot take ACE inhibitors, have no initial therapy or are unresponsive to monotherapy.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Renal tubular acidosis
0 Actively Recruiting
Diabetes Insipidus
2 Actively Recruiting
Phase 1, Phase 2
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Nephrolithiasis
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
hypokalemia with solo treatment
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
calcium channel blockers
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Telmisartan And Hydrochlorothiazide Reviews: What are patients saying about Telmisartan And Hydrochlorothiazide?
4.3Patient Review
3/26/2013 I switched from the name brand to a generic brand and started experiencing nose bleeds, which I've never had before. Has anyone else had this problem after taking Telmisartan?
4Patient Review
10/22/2010 I'm experiencing muscle pain and weakness, as well as periodic waves of dizziness. I also had a severe reaction in the form of hives. I'm changing physicians and requesting that we change medication.
4Patient Review
4/24/2015 I've been on this medication for seven years and it has done wonders for my blood pressure. My doctor tried a bunch of different treatments before finding this one, and I'm so glad he did. It's made a world of difference.
4Patient Review
9/28/2010 The only issue I have is remembering to take the medicine, especially when I'm feeling fine.
4Patient Review
3/25/20083.7Patient Review
12/20/2015 This drug is very effective. I'm glad I found it.
2.7Patient Review
5/19/2020 I have been taking this medication for 3 weeks now with no significant results.
2.7Patient Review
3/24/2014 Unfortunately, I experienced some intense pain in my lower back after taking this medication.
1.7Patient Review
11/7/2016 I took Diovan for six years without any real issues, other than the cost per pill going up to $4.50. However, in the last two months I noticed it hasn't been controlling my blood pressure as well as it used to.
1.7Patient Review
10/5/2012 This treatment works well and I haven't experienced any negative side effects.
Patient Q&A Section about telmisartan and hydrochlorothiazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the dangers of taking hydrochlorothiazide?
"You should speak to your doctor if you experience any of the following symptoms as they may be indicative of an underlying issue: seizures, decreased urine output, drowsiness, dry mouth, excessive thirst, increased heart rate or pulse, muscle pains or cramps, nausea or vomiting, or unusual tiredness or weakness."
Answered by AI
What are the side effects of telmisartan hydrochlorothiazide?
"You may have bladder pain, decreased urine, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position. You may also have a fast, pounding, or irregular heartbeat or pulse, increased thirst, muscle pain or cramps, nausea or vomiting, and numbness or tingling in the hands, feet, or lips."
Answered by AI
When should I take telmisartan and hydrochlorothiazide tablets?
"swallows This medication is usually taken once a day. You can take it with or without food. Try to take it at the same time each day. If you have trouble sleeping, avoid taking it too close to bedtime. If you have any questions about your dose, talk to your doctor or pharmacist."
Answered by AI
What is telmisartan and hydrochlorothiazide used for?
"Telmisartan and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure puts extra strain on the heart and arteries. If it continues for a long time, the heart and arteries may not function properly."
Answered by AI