Sunosi

Narcolepsy, Disorders of Excessive Somnolence, Obstructive Sleep Apnea
Treatment
20 Active Studies for Sunosi

What is Sunosi

SolriamfetolThe Generic name of this drug
Treatment SummarySolriamfetol, also known as Sunosi, is a medication used to reduce daytime sleepiness caused by narcolepsy or obstructive sleep apnea. It works by blocking the reuptake of dopamine and norepinephrine, two neurotransmitters that regulate wakefulness. The drug was approved by the FDA in 2019.
Sunosiis the brand name
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Sunosi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sunosi
Solriamfetol
2019
4

Effectiveness

How Sunosi Affects PatientsSolriamfetol binds weakly to certain transporters for dopamine and norepinephrine but not serotonin. It does not bind to any other substances or receptors like GABA, adenosine, and histamine. Taking 300mg (twice the maximum recommended dose) of solriamfetol has been associated with an increase in heart rate of 21 beats per minute, and 900mg (six times the maximum recommended dose) has been associated with a 27 beat increase. 300mg of solriamfetol does not significantly affect the QTcF interval.
How Sunosi works in the bodyThe exact way this drug works is not clear, but it may work by blocking the reabsorption of the neurotransmitters dopamine and norepinephrine.

When to interrupt dosage

The suggested dosage of Sunosi depends on the diagnosed medical state, including Daytime Sleepiness, Obstructive Sleep Apnea and Narcolepsy. The quantity of dosage is contingent upon the mode of administration (e.g. Tablet - Oral or Tablet, film coated - Oral) indicated in the table below.
Condition
Dosage
Administration
Narcolepsy
75.0 mg, , 150.0 mg
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, Tablet - Oral
Disorders of Excessive Somnolence
75.0 mg, , 150.0 mg
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, Tablet - Oral
Obstructive Sleep Apnea
75.0 mg, , 150.0 mg
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, Tablet - Oral

Warnings

Sunosi Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Sunosi.
Common Sunosi Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Solriamfetol.
Azelastine
Major
Solriamfetol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Solriamfetol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Iobenguane
Major
Solriamfetol can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Solriamfetol is combined with Oliceridine.
Sunosi Toxicity & Overdose RiskSolriamfetol’s effects are not influenced by age, gender, or race, so no dosage adjustments are necessary for patients over 65. People with kidney problems may have higher levels of the drug in their body and should adjust their dose accordingly. Solriamfetol has been found to cause harm to pregnant animals, so it should not be taken during pregnancy. Breastfeeding infants should be monitored for side effects such as agitation, insomnia, anorexia, and slow weight gain, as the drug can be found in breastmilk. No clinical studies have been conducted on the drug’s safety and effectiveness in children
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Sunosi Novel Uses: Which Conditions Have a Clinical Trial Featuring Sunosi?

Ninety clinical trials are currently evaluating the potential of Sunosi to alleviate Obstructive Sleep Apnea, Narcolepsy and Daytime Sleepiness.
Condition
Clinical Trials
Trial Phases
Obstructive Sleep Apnea
82 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1, Early Phase 1
Narcolepsy
1 Actively Recruiting
Phase 1
Disorders of Excessive Somnolence
0 Actively Recruiting

Sunosi Reviews: What are patients saying about Sunosi?

4Patient Review
1/25/2020
Sunosi for Recurring Sleep Episodes During the Day
This medication helps me stay awake for long periods of time without making my anxiety worse, which is a problem I have with most stimulants. However, it doesn't seem to help with my insomnia.
2.7Patient Review
8/5/2021
Sunosi for Recurring Sleep Episodes During the Day
I have narcolepsy and was hoping this medication would be an effective replacement for Adderall. Unfortunately, I have experienced no improvement in my condition after four weeks of use. In fact, I feel worse than before with constant dizziness and a lack of motivation. For anyone suffering from narcolepsy, I would not recommend this treatment.
2Patient Review
1/15/2020
Sunosi for Sleepiness Due To Obstructive Sleep Apnea
1Patient Review
2/12/2020
Sunosi for Recurring Sleep Episodes During the Day
Unfortunately I had to stop using this after just three days because the side effects were too much for me. These included high blood pressure, headaches, and stomach problems like acid reflux.
1Patient Review
8/12/2020
Sunosi for Sleepiness Due To Obstructive Sleep Apnea
I was on Modafinil for a while, but it eventually stopped working. I tried it again after a couple months and found that it worked much better the second time around.
View All Reviews
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Patient Q&A Section about sunosi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Sunosi a stimulant?

"SUNOSI is not a stimulant; it is a type of medication called a wake-promoting agent. Do not take SUNOSI if you have taken, or stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI)."

Answered by AI

What drug is similar to Sunosi?

"Some possible alternative drugs for treating obstructive sleep apnea (OSA) include armodafinil and modafinil."

Answered by AI

What's the difference between Sunosi and Adderall?

"The active drug in Sunosi is solriamfetol, while the active drugs in Adderall are dextroamphetamine and amphetamine. These medications belong to different drug classes."

Answered by AI

What kind of medication is Sunosi?

"What is Sunosi? Sunosi is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea."

Answered by AI

Clinical Trials for Sunosi

Have you considered Sunosi clinical trials? We made a collection of clinical trials featuring Sunosi, we think they might fit your search criteria.
Have you considered Sunosi clinical trials? We made a collection of clinical trials featuring Sunosi, we think they might fit your search criteria.
Have you considered Sunosi clinical trials? We made a collection of clinical trials featuring Sunosi, we think they might fit your search criteria.
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