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What is Silvadene
Silver sulfadiazineThe Generic name of this drug
Treatment SummarySilver sulfadiazine is an antibacterial medication used to treat severe burn wounds. It is applied directly to the skin and helps prevent infection in second- and third-degree burns.
Silvadeneis the brand name
Silvadene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Silvadene
Silver sulfadiazine
1973
69
Approved as Treatment by the FDA
Silver sulfadiazine, also known as Silvadene, is approved by the FDA for 1 uses which include Wound Infections .Wound Infections
Used to treat Wound Infections in combination with Chlorhexidine
Effectiveness
How Silvadene Affects PatientsSilver sulfadiazine is an effective antibiotic that can kill many types of bacteria and yeast. It is different than other antibiotics in that it does not block a specific enzyme, which could be beneficial in certain situations.
How Silvadene works in the bodySilver sulfadiazine works to kill bacteria by targeting the cell membrane and cell wall. It does this by binding to several parts of the bacteria, such as nucleophilic amino acids and sulfhydryl, amino, imidazole, phosphate, and carboxyl groups of proteins. Silver also makes the membrane more porous, which leads to the death of the cell. Sulfadiazine, meanwhile, stops the bacteria from producing folic acid, which it needs to survive. Together, these two components work in synergy, creating a stronger effect than either one alone.
When to interrupt dosage
The measure of Silvadene is contingent upon the detected illness, including Septicemia, Second Degree Burns and Third Degree Burns. The dosage amount is subject to the technique of delivery, as specified in the table below.Condition
Dosage
Administration
Alopecia
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Topical, Cream, Cream - Topical, Gel - Topical, Gel
Septicemia
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Topical, Cream, Cream - Topical, Gel - Topical, Gel
Wound Infections
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Topical, Cream, Cream - Topical, Gel - Topical, Gel
Second Degree Burns
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Topical, Cream, Cream - Topical, Gel - Topical, Gel
Warnings
Silvadene ContraindicationsCondition
Risk Level
Notes
Prematurity
Do Not Combine
Kernicterus
Do Not Combine
newborn infants during the first 2 months of life
Do Not Combine
Common Silvadene Drug Interactions
Drug Name
Risk Level
Description
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
Major
The therapeutic efficacy of Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen can be decreased when used in combination with Silver sulfadiazine.
Benzylpenicillin
Moderate
Silver sulfadiazine may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol
Moderate
The therapeutic efficacy of Estetrol can be decreased when used in combination with Silver sulfadiazine.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin argine.
Insulin aspart
Moderate
The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin aspart.
Silvadene Toxicity & Overdose RiskThe lowest toxic dose of this drug when taken orally by a rat has been found to be 10001mg/kg.
Silvadene Novel Uses: Which Conditions Have a Clinical Trial Featuring Silvadene?
Two active studies are presently examining the capability of Silvadene in providing relief for Third Degree Burns, Second Degree Burns and Wound Infections.Condition
Clinical Trials
Trial Phases
Septicemia
0 Actively Recruiting
Wound Infections
0 Actively Recruiting
Alopecia
0 Actively Recruiting
Second Degree Burns
2 Actively Recruiting
Phase 2, Phase 3
Silvadene Reviews: What are patients saying about Silvadene?
5Patient Review
5/7/2014 This drug is very old but it's still an amazing burn treatment that helps prevent infection. I had severe burns over a large portion of my lower body and this worked miracles.
5Patient Review
10/5/2013 This cream is an absolute godsend for burns.
5Patient Review
7/13/2021 Silvadene was an absolute life saver for me when I had third degree burns on both of my hands. It helped with the pain more than any other medication I was on, and due to its use I didn't need skin grafts.
5Patient Review
12/11/2018 Silvadene did an excellent job of healing my surgical wound and preventing scarring. I've also used it for radiator burns with great success.
5Patient Review
9/28/2016 My son recommended this cream to me for my diabetic ulcer, and I have to say that I was really impressed with how quickly it healed my wound.
5Patient Review
9/17/2017 I was in a motorcycle accident and slid on the road. I used Silvadene for seven months to treat the wound and it healed perfectly with no infection.
5Patient Review
12/25/20113.7Patient Review
1/16/20122.7Patient Review
6/28/2014 This treatment worked well for me and I was very pleased with the results. The burn healed quickly and with no problems.
1Patient Review
3/8/2014 I had an accident at work and ended up scalding my hand with boiling water. I used this cream afterwards as per instructions, and it did wonders in reducing the redness and swelling.
Patient Q&A Section about silvadene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can you buy Silvadene over the counter?
"Why can't you get Silvadene over the counter?
You can't get Silvadene over the counter because it has to be prescribed by a healthcare provider."
Answered by AI
What is Silvadene cream used for?
"The cream is to be applied over the wound surface as a thin film at least once daily or more often if required, and covered with a sterile gauze dressing.
SILVADENE Cream 1% (silver sulfadiazine) is a topical cream that helps prevent and treat wound infections in patients with second- and third-degree burns. Apply the cream to the wound surface as a thin film at least once daily, or more often if needed. Cover the wound with a sterile gauze dressing."
Answered by AI
Why is Silvadene not recommended?
"This product is not recommended for patients with severe allergic reactions after using it, pregnant women near their due date, premature babies, or infants under 2 months old."
Answered by AI
Do you need a prescription for Silvadene cream?
"Silvadene is a prescription medicine used to treat the symptoms of burn wound infections. It may be used alone or with other medications. Silvadene belongs to a class of drugs called Antibacterials, Topical."
Answered by AI