← Back to Search

Behavioral Intervention

Transdiagnostic Behavior Therapy for Depression and PTSD

N/A
Recruiting
Led By Daniel F Gros, PhD MA BS
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must meet DSM-5 criteria for panic disorder, major depressive disorder, or posttraumatic stress disorder
Participants must be 18-80 years old
Must not have
acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer)
diagnosis of moderate-to-severe traumatic brain injury in their medical record and/or endorsement of screener questionnaire
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to week 6 to week 12 to 6-month followup
Awards & highlights

Summary

This trial will compare the effectiveness of a new treatment, transdiagnostic behavior therapy (TBT), against existing treatments for veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder.

Who is the study for?
This trial is for Veterans aged 18-80 with depression, PTSD, or panic disorder who can consent to research. It's not for those recently hospitalized for psychiatric reasons, have severe illnesses like active cancer treatment, or started new psychiatric meds in the last month.Check my eligibility
What is being tested?
The study compares Transdiagnostic Behavior Therapy (TBT), a single protocol therapy designed to treat various disorders at once, with specific Cognitive Behavioral Therapies tailored individually for major depressive disorder (MDD), PTSD, and panic disorder.See study design
What are the potential side effects?
While this trial involves psychological therapies rather than medications, participants may experience emotional discomfort discussing personal issues. Side effects are generally less severe than those associated with medication but can include increased anxiety or stress.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with panic disorder, major depression, or PTSD.
Select...
I am between 18 and 80 years old.
Select...
I understand and can agree to the study's requirements.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I do not have a severe illness that would require hospitalization or interfere with the study.
Select...
I have a moderate-to-severe traumatic brain injury.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to week 6 to week 12 to 6-month followup
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to week 6 to week 12 to 6-month followup for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
PTSD Checklist for DSM-5 (PCL-5)
Panic Disorder Severity Scale (PDSS)
Patient Health Questionnaire - 9 (PHQ-9)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Transdiagnostic Behavior TherapyExperimental Treatment1 Intervention
TBT was developed to address transdiagnostic avoidance via the use of four different types of exposure techniques (situational/in-vivo, physical/interoceptive, thought/imaginal, and [positive] emotional/behavioral activation). From the transdiagnostic avoidance perspective, the four exposure practices are matched to the type(s) of avoidance experienced by patients based upon their cluster of symptoms/disorders.
Group II: Disorder Specific TherapiesActive Control3 Interventions
To provide an evidence-based comparison for the TBT condition, DSTs will be used that are matched to the participant's most severe diagnosis, based upon the average of the ADIS interference and distress scores. If the scores are equivalent for two or more diagnoses, participants will be asked to list which diagnosis/symptoms that they find most impairing. DSTs will be included for each of the three targeted diagnoses, including PTSD (CPT for PTSD), PD/AG (CBT for PD/AG), and MDD (CBT for MDD). Each of these DSTs have published manuals for administration and have received extensive support in the literature (Barlow, 2014).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transdiagnostic Behavior Therapy
2014
N/A
~110

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,628 Previous Clinical Trials
3,325,763 Total Patients Enrolled
Daniel F Gros, PhD MA BSPrincipal InvestigatorRalph H. Johnson VA Medical Center, Charleston, SC
3 Previous Clinical Trials
663 Total Patients Enrolled

Media Library

Cognitive Behavioral Therapy for MDD (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04293341 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Disorder Specific Therapies, Transdiagnostic Behavior Therapy
Post-Traumatic Stress Disorder Clinical Trial 2023: Cognitive Behavioral Therapy for MDD Highlights & Side Effects. Trial Name: NCT04293341 — N/A
Cognitive Behavioral Therapy for MDD (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04293341 — N/A
~9 spots leftby Oct 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top