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Behavioral Intervention

Transdiagnostic Behavior Therapy for Depression and PTSD

N/A
Recruiting
Led By Daniel F Gros, PhD MA BS
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must meet DSM-5 criteria for panic disorder, major depressive disorder, or posttraumatic stress disorder
Participants must be 18-80 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to week 6 to week 12 to 6-month followup
Awards & highlights

Study Summary

This trial will compare the effectiveness of a new treatment, transdiagnostic behavior therapy (TBT), against existing treatments for veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder.

Who is the study for?
This trial is for Veterans aged 18-80 with depression, PTSD, or panic disorder who can consent to research. It's not for those recently hospitalized for psychiatric reasons, have severe illnesses like active cancer treatment, or started new psychiatric meds in the last month.Check my eligibility
What is being tested?
The study compares Transdiagnostic Behavior Therapy (TBT), a single protocol therapy designed to treat various disorders at once, with specific Cognitive Behavioral Therapies tailored individually for major depressive disorder (MDD), PTSD, and panic disorder.See study design
What are the potential side effects?
While this trial involves psychological therapies rather than medications, participants may experience emotional discomfort discussing personal issues. Side effects are generally less severe than those associated with medication but can include increased anxiety or stress.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with panic disorder, major depression, or PTSD.
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I am between 18 and 80 years old.
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I understand and can agree to the study's requirements.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to week 6 to week 12 to 6-month followup
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to week 6 to week 12 to 6-month followup for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
PTSD Checklist for DSM-5 (PCL-5)
Panic Disorder Severity Scale (PDSS)
Patient Health Questionnaire - 9 (PHQ-9)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Transdiagnostic Behavior TherapyExperimental Treatment1 Intervention
TBT was developed to address transdiagnostic avoidance via the use of four different types of exposure techniques (situational/in-vivo, physical/interoceptive, thought/imaginal, and [positive] emotional/behavioral activation). From the transdiagnostic avoidance perspective, the four exposure practices are matched to the type(s) of avoidance experienced by patients based upon their cluster of symptoms/disorders.
Group II: Disorder Specific TherapiesActive Control3 Interventions
To provide an evidence-based comparison for the TBT condition, DSTs will be used that are matched to the participant's most severe diagnosis, based upon the average of the ADIS interference and distress scores. If the scores are equivalent for two or more diagnoses, participants will be asked to list which diagnosis/symptoms that they find most impairing. DSTs will be included for each of the three targeted diagnoses, including PTSD (CPT for PTSD), PD/AG (CBT for PD/AG), and MDD (CBT for MDD). Each of these DSTs have published manuals for administration and have received extensive support in the literature (Barlow, 2014).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transdiagnostic Behavior Therapy
2014
N/A
~110

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,609 Previous Clinical Trials
3,306,388 Total Patients Enrolled
Daniel F Gros, PhD MA BSPrincipal InvestigatorRalph H. Johnson VA Medical Center, Charleston, SC
3 Previous Clinical Trials
663 Total Patients Enrolled

Media Library

Cognitive Behavioral Therapy for MDD (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04293341 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Disorder Specific Therapies, Transdiagnostic Behavior Therapy
Post-Traumatic Stress Disorder Clinical Trial 2023: Cognitive Behavioral Therapy for MDD Highlights & Side Effects. Trial Name: NCT04293341 — N/A
Cognitive Behavioral Therapy for MDD (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04293341 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor accept participants over 25 years of age?

"This clinical trial is looking for participants aged 18 to 80. However, due to the nature of this research, there are 366 studies specifically catered towards minors and 1357 trials orientated towards seniors."

Answered by AI

Are new participants being accepted into this experiment?

"Absolutely, the information on clinicaltrials.gov confirms that this research is still seeking participants. Starting October 1st 2020 and last updated April 7th 2022, this trial has 216 spots to fill at a single location."

Answered by AI

What is the total number of participants included in this experiment?

"Affirmative. According to the information furnished on clinicaltrials.gov, this research is actively looking for volunteers and was initially posted in October 2020 before being updated most recently on April 7th 2022. A total of 216 participants are needed from a single location."

Answered by AI

What are the eligibility requirements for participation in this investigation?

"In order to qualify for this clinical trial, patients must have psychosis and be between the ages of 18-80. The investigation is looking to recruit a total of 216 participants."

Answered by AI
~22 spots leftby Oct 2024