Transdiagnostic Behavior Therapy for Psychosis, Involutional

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Psychosis, Involutional+8 More
Transdiagnostic Behavior Therapy - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare the effectiveness of a new treatment, transdiagnostic behavior therapy (TBT), against existing treatments for veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder.

Eligible Conditions
  • Psychosis, Involutional
  • Major Depressive Disorder (MDD)
  • Agoraphobia
  • Post Traumatic Stress Disorder (PTSD)

Treatment Effectiveness

Study Objectives

3 Primary · 0 Secondary · Reporting Duration: change from baseline to week 6 to week 12 to 6-month followup

Week 12
PTSD Checklist for DSM-5 (PCL-5)
Panic Disorder Severity Scale (PDSS)
Patient Health Questionnaire - 9 (PHQ-9)

Trial Safety

Trial Design

2 Treatment Groups

Disorder Specific Therapies
1 of 2
Transdiagnostic Behavior Therapy
1 of 2

Active Control

Experimental Treatment

216 Total Participants · 2 Treatment Groups

Primary Treatment: Transdiagnostic Behavior Therapy · No Placebo Group · N/A

Transdiagnostic Behavior Therapy
Behavioral
Experimental Group · 1 Intervention: Transdiagnostic Behavior Therapy · Intervention Types: Behavioral
Disorder Specific TherapiesActiveComparator Group · 3 Interventions: Cognitive Behavioral Therapy for Panic Disorder, Cognitive Behavioral Therapy for MDD, Cognitive Processing Therapy for PTSD · Intervention Types: Behavioral, Behavioral, Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transdiagnostic Behavior Therapy
2014
N/A
~110

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: change from baseline to week 6 to week 12 to 6-month followup

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,474 Previous Clinical Trials
2,741,478 Total Patients Enrolled
Daniel F Gros, PhD MA BSPrincipal InvestigatorRalph H. Johnson VA Medical Center, Charleston, SC
2 Previous Clinical Trials
313 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You must meet the criteria for a mental disorder.
You must be willing to participate in the study.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 7th, 2021

Last Reviewed: November 3rd, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.