Serevent

Asthma, Chronic Obstructive Pulmonary Disease, Bronchospasm, Exercise-Induced + 1 more

Treatment

7 FDA approvals

20 Active Studies for Serevent

Treatment for

Asthma

What is Serevent

SalmeterolThe Generic name of this drug

Treatment SummarySalmeterol is an asthma and COPD medication that works by activating the beta-2 adrenergic receptors in the lungs. It has a longer duration of action than other medications used to treat asthma and COPD, like salbutamol. The structure of salmeterol is similar to salbutamol, but with a different substitution on the amine. Salmeterol was approved by the FDA in 1994.

Serevent Diskusis the brand name

image of different drug pills on a surface

Serevent Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Serevent Diskus

Salmeterol

1997

Approved as Treatment by the FDA

Salmeterol, otherwise called Serevent Diskus, is approved by the FDA for 7 uses including Asthma, Exercise-Induced and Asthma .

Asthma, Exercise-Induced

Asthma

Used to treat Asthma in combination with Fluticasone propionate

Exercise-Induced Bronchospasm

prophylaxis of Exercise-induced bronchospasm

Asthma

Used to treat Asthma in combination with Fluticasone propionate

Chronic Obstructive Pulmonary Disease

Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Bronchospasm, Exercise-Induced

Effectiveness

How Serevent Affects PatientsSalmeterol is an inhaled drug that works to relax the airways in the lungs, helping to make breathing easier. This drug is longer lasting than other similar drugs, however patients should be warned of potential risks such as low potassium levels or low blood sugar, and should not take it with another long-acting beta agonist.

How Serevent works in the bodySalmeterol is believed to relax the airways, allowing more air to flow through and causing bronchodilation. It does this by binding to two sites on the beta-2 adrenoceptor. The active site binds the saligenin moiety, while the exo-site binds the hydrophilic tail of salmeterol. This allows the drug to remain in the active site for a long time, making its effects last longer. It is also thought that Salmeterol diffuses into the cells' lipid layers, providing a reservoir of the drug for a longer period of time.

When to interrupt dosage

The prescribed measure of Serevent is contingent upon the diagnosed state, including Exercise-Induced Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm, Exercise-Induced. The dosage diverges, as per the administration technique shown in the table below.

Condition

Dosage

Administration

Bronchospasm, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Powder - Respiratory (inhalation), Powder, Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)

Asthma, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Asthma

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Chronic Obstructive Pulmonary Disease

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Warnings

Serevent Contraindications

Condition

Risk Level

Notes

Status Asthmaticus

Do Not Combine

Chronic Obstructive Airway Disease

Do Not Combine

Not being treated with an inhaled corticosteroid

Do Not Combine

Asthma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Salmeterol may interact with Pulse Frequency

There are 20 known major drug interactions with Serevent.

Common Serevent Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Salmeterol.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Salmeterol.

Almotriptan

Major

The metabolism of Almotriptan can be decreased when combined with Salmeterol.

Aminophenazone

Major

The metabolism of Aminophenazone can be decreased when combined with Salmeterol.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Salmeterol.

Serevent Toxicity & Overdose RiskPeople who overdose on salmeterol may experience an acidic bloodstream, high lactic acid levels, and symptoms such as anxiety, rapid heartbeat, depression of the heart's electrical activity, low potassium, low phosphate, seizures, high or low blood pressure, headache, trembling, muscle cramps, dry mouth, nausea, fatigue, general discomfort, insomnia, and high blood sugar. Treatment may include fluids, potassium supplements, a heart-selective beta blocker, and monitoring of the heart. The exact toxic dose of salmeterol is unknown.

image of a doctor in a lab doing drug, clinical research

Serevent Novel Uses: Which Conditions Have a Clinical Trial Featuring Serevent?

At present, 244 active trials are assessing the utility of Serevent in providing relief from Exercise-Induced Bronchospasm, Bronchospasm, Exercise-Induced Dyspnea and Chronic Obstructive Pulmonary Disease (COPD).

Condition

Clinical Trials

Trial Phases

Asthma

92 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Chronic Obstructive Pulmonary Disease

77 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Bronchospasm, Exercise-Induced

0 Actively Recruiting

Asthma, Exercise-Induced

0 Actively Recruiting

Serevent Reviews: What are patients saying about Serevent?

5Patient Review

11/19/2007

Serevent for Asthma

I've been using Serevent for a decade now, and it's been incredible. Before this, I was having to use a maximum dosage of Provental or a similar medication every couple of months just to stay afloat--but since switching to Serevent, I haven't had to touch either of those things. It's really been a game-changer for me.

5Patient Review

6/27/2010

Serevent for Asthma

After using this treatment for two years, I suddenly started experiencing severe muscle cramping all over my body. Has anyone else had this problem?

5Patient Review

6/30/2011

Serevent for Asthma

This treatment is for COPD and it works. I use it twice a day, and I don't need to use my rescue inhaler more than that.

5Patient Review

10/8/2007

Serevent for Asthma

5Patient Review

11/6/2007

Serevent for Asthma

4.3Patient Review

10/27/2007

Serevent for Asthma

3.7Patient Review

3/10/2009

Serevent for Asthma

This medication helped me a lot by addressing my hacking cough and labored breathing. The only downside is that I have to take it twice a day, which can be inconvenient. Additionally, I wish the manufacturer would make the PEF online calculator more accessible.

3.3Patient Review

6/15/2009

Serevent for Asthma

This medication is pretty effective; I only have to use it once a day most of the time. There have been stretches where I've gone weeks without using it and had no asthma symptoms.

3Patient Review

3/14/2010

Serevent for Asthma

I was wondering if anyone knows if you're supposed to rinse your mouth and spit out the water after using serevent, like the directions say to do with aerobid.

2.3Patient Review

9/2/2009

Serevent for Asthma

My exercise-induced asthma and nighttime stuffy nose both saw significant improvement. I did experience a mild rash that didn't respond to hydrocortisone, but Fluocinolone Acetonide cream alleviated it. I told my doctor that, in general, being physically active and getting enough sleep makes for a happier person and patient.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about serevent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Serevent the same as Advair?

"ADVAIR contains the same medicine, salmeterol, as is found in SEREVENT DISKUS. LABA medicines, of which salmeterol is one, when used alone increase the risk of hospitalizations and death from asthma problems."

Answered by AI

Is Serevent a steroid?

"Serevent Diskus (salmeterol) is not a steroid. It belongs to the drug class called long-acting beta-agonist (LABA), which works by relaxing the muscles that allow air into your lungs. There is no need to rinse your mouth after using it."

Answered by AI

What kind of inhaler is Serevent?

"The doctor prescribed me Serevent Inhaler CFC-Free to help with my asthma. The medicine is a bronchodilator which helps to keep the airways in my lungs open. This relieves the symptoms of asthma and makes it easier for me to breathe."

Answered by AI

What is Serevent prescribed for?

"This medication is designed for long-term use in people who have difficulty breathing due to COPD. This can include emphysema and chronic bronchitis."

Answered by AI

Clinical Trials for Serevent

Image of Stanford University in Stanford, United States.

MoblO2 for Chronic Lung Diseases

18+

All Sexes

Stanford, CA

Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); 3) that it will stave off putative complications of hypoxemia (e.g., cognitive dysfunction, pulmonary hypertension) and 4) that it will improve health-related quality of life (HRQL). However, despite the rationale for O2, and prescribers' good intentions, patients generally view O2 with frustration and fear - it threatens their HRQL, which is already impaired by having a condition that imposes itself on every aspect of their lives. Nasal cannulas and delivery devices call unwanted attention to patients when they are out in public. O2 users feel stigmatized and are often viewed as "smokers who get what they deserve, even if they never smoked a day in their lives" - or as disabled, sick or even infectious. O2 steals patients' independence, forcing them to plan their lives around it. The anxiety that patients and their caregivers experience around running out of oxygen, or not getting enough, immobilizes them and restricts participation in activities outside of the home. O2 disrupts the home environment, adding stress, and creating a burden for patients' caregiver-loved-ones who are often saddled with the responsibility of ensuring adequate equipment and supply of O2, and O2 is a constant reminder to patients they are living with a condition that could shorten their lives. O2 delivery equipment is typically heavy, unwieldy and intimidating. Different recommendations (e.g., insurance companies use 88% as a cut-off for SpO2, while many practitioners focus on 90%) make it confusing for patients, which almost certainly affects adherence. O2-requiringpatients are starving for things that can make their lives easier. An auto-adjusting O2 delivery device - one that automatically delivers the correct amount of O2 to maintain blood oxygen at desired, pre-set levels - would alleviate the need for patients to constantly (incessantly for many) monitor their peripheral oxygen saturation (SpO2) and adjust O2flow to meet the demands as exertion levels vary . The MoblO2 device is a battery-operated, light-weight, closed-loop O2 delivery device that houses a regulator (which attaches to compressed gas O2 tanks) and adjusts O2 flow to meet a pre-set blood oxygen level. A pulse oximeter is worn on the ear and transmits via Bluetooth to the device, which adjusts an internal valve to control flow on a second-to-second basis. The user sets the dial to the highest flow of O2 needed to meet the demands of activities they might perform (up to 15 liters per minute), and the device adjusts flow, up to the pre-set level to maintain SpO2 at a preset level (e.g., \> 90%). To conserve O2 supply in the tank - and to avoid over-oxygenation (which could be problematic for a small percentage of patients with the most severe COPD) - the MoblO2 begins to limit O2 flow at a SpO2 of 93%. The device can be manually over-ridden by the user, and should the battery run out - or the device fail for some unforeseen reason - the default position is valve open, so the users receive whatever flow of oxygen has been set on the dial. Given the substantial burdens of O2 on patients and their families, the hassles patients describe with having to monitor their SpO2 and repeatedly adjust the flow of O2 to meet their needs, patients and experts around the world have called for improvements in O2 delivery equipment. The MoblO2 is just such a remarkable improvement and a giant step forward in helping to ease the burdens of O2 on patients who require it. The purpose of this study is to investigate the effects of the MoblO2 O2 delivery device on a range of outcomes, including physical activity, amount (liters) O2 use; maintenance of adequate SpO2 levels; patient reported outcomes including symptoms, HRQL and satisfaction with the MoblO2 O2 device.

Waitlist Available

Has No Placebo

Stanford UniversityJeff Swigris, DO, MSMinnesota Health Solutions

Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.

Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.