Serevent

Asthma, Chronic Obstructive Pulmonary Disease, Bronchospasm, Exercise-Induced + 1 more

Treatment

7 FDA approvals

20 Active Studies for Serevent

Treatment for

Asthma

What is Serevent

SalmeterolThe Generic name of this drug

Treatment SummarySalmeterol is an asthma and COPD medication that works by activating the beta-2 adrenergic receptors in the lungs. It has a longer duration of action than other medications used to treat asthma and COPD, like salbutamol. The structure of salmeterol is similar to salbutamol, but with a different substitution on the amine. Salmeterol was approved by the FDA in 1994.

Serevent Diskusis the brand name

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Serevent Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Serevent Diskus

Salmeterol

1997

Approved as Treatment by the FDA

Salmeterol, otherwise called Serevent Diskus, is approved by the FDA for 7 uses including Asthma, Exercise-Induced and Exercise-Induced Bronchospasm .

Asthma, Exercise-Induced

Exercise-Induced Bronchospasm

Asthma

Used to treat Asthma in combination with Fluticasone propionate

prophylaxis of Exercise-induced bronchospasm

Asthma

Used to treat Asthma in combination with Fluticasone propionate

Chronic Obstructive Pulmonary Disease

Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Bronchospasm, Exercise-Induced

Effectiveness

How Serevent Affects PatientsSalmeterol is an inhaled drug that works to relax the airways in the lungs, helping to make breathing easier. This drug is longer lasting than other similar drugs, however patients should be warned of potential risks such as low potassium levels or low blood sugar, and should not take it with another long-acting beta agonist.

How Serevent works in the bodySalmeterol is believed to relax the airways, allowing more air to flow through and causing bronchodilation. It does this by binding to two sites on the beta-2 adrenoceptor. The active site binds the saligenin moiety, while the exo-site binds the hydrophilic tail of salmeterol. This allows the drug to remain in the active site for a long time, making its effects last longer. It is also thought that Salmeterol diffuses into the cells' lipid layers, providing a reservoir of the drug for a longer period of time.

When to interrupt dosage

The prescribed measure of Serevent is contingent upon the diagnosed state, including Exercise-Induced Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm, Exercise-Induced. The dosage diverges, as per the administration technique shown in the table below.

Condition

Dosage

Administration

Bronchospasm, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)

Asthma, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Asthma

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Chronic Obstructive Pulmonary Disease

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Warnings

Serevent Contraindications

Condition

Risk Level

Notes

Status Asthmaticus

Do Not Combine

Chronic Obstructive Airway Disease

Do Not Combine

Not being treated with an inhaled corticosteroid

Do Not Combine

Asthma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Salmeterol may interact with Pulse Frequency

There are 20 known major drug interactions with Serevent.

Common Serevent Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Salmeterol.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Salmeterol.

Almotriptan

Major

The metabolism of Almotriptan can be decreased when combined with Salmeterol.

Aminophenazone

Major

The metabolism of Aminophenazone can be decreased when combined with Salmeterol.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Salmeterol.

Serevent Toxicity & Overdose RiskPeople who overdose on salmeterol may experience an acidic bloodstream, high lactic acid levels, and symptoms such as anxiety, rapid heartbeat, depression of the heart's electrical activity, low potassium, low phosphate, seizures, high or low blood pressure, headache, trembling, muscle cramps, dry mouth, nausea, fatigue, general discomfort, insomnia, and high blood sugar. Treatment may include fluids, potassium supplements, a heart-selective beta blocker, and monitoring of the heart. The exact toxic dose of salmeterol is unknown.

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Serevent Novel Uses: Which Conditions Have a Clinical Trial Featuring Serevent?

At present, 244 active trials are assessing the utility of Serevent in providing relief from Exercise-Induced Bronchospasm, Bronchospasm, Exercise-Induced Dyspnea and Chronic Obstructive Pulmonary Disease (COPD).

Condition

Clinical Trials

Trial Phases

Asthma

86 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Chronic Obstructive Pulmonary Disease

84 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4

Bronchospasm, Exercise-Induced

0 Actively Recruiting

Asthma, Exercise-Induced

1 Actively Recruiting

Not Applicable

Serevent Reviews: What are patients saying about Serevent?

5Patient Review

11/19/2007

Serevent for Asthma

I've been using Serevent for a decade now, and it's been incredible. Before this, I was having to use a maximum dosage of Provental or a similar medication every couple of months just to stay afloat--but since switching to Serevent, I haven't had to touch either of those things. It's really been a game-changer for me.

5Patient Review

6/27/2010

Serevent for Asthma

After using this treatment for two years, I suddenly started experiencing severe muscle cramping all over my body. Has anyone else had this problem?

5Patient Review

6/30/2011

Serevent for Asthma

This treatment is for COPD and it works. I use it twice a day, and I don't need to use my rescue inhaler more than that.

5Patient Review

10/8/2007

Serevent for Asthma

5Patient Review

11/6/2007

Serevent for Asthma

View All Reviews

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Patient Q&A Section about serevent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Serevent the same as Advair?

"ADVAIR contains the same medicine, salmeterol, as is found in SEREVENT DISKUS. LABA medicines, of which salmeterol is one, when used alone increase the risk of hospitalizations and death from asthma problems."

Answered by AI

Is Serevent a steroid?

"Serevent Diskus (salmeterol) is not a steroid. It belongs to the drug class called long-acting beta-agonist (LABA), which works by relaxing the muscles that allow air into your lungs. There is no need to rinse your mouth after using it."

Answered by AI

What kind of inhaler is Serevent?

"The doctor prescribed me Serevent Inhaler CFC-Free to help with my asthma. The medicine is a bronchodilator which helps to keep the airways in my lungs open. This relieves the symptoms of asthma and makes it easier for me to breathe."

Answered by AI

What is Serevent prescribed for?

"This medication is designed for long-term use in people who have difficulty breathing due to COPD. This can include emphysema and chronic bronchitis."

Answered by AI

Clinical Trials for Serevent

Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.

Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.