Serevent

Asthma, Chronic Obstructive Pulmonary Disease, Bronchospasm, Exercise-Induced + 1 more
Treatment
4 FDA approvals
20 Active Studies for Serevent

What is Serevent

SalmeterolThe Generic name of this drug
Treatment SummarySalmeterol is an asthma and COPD medication that works by activating the beta-2 adrenergic receptors in the lungs. It has a longer duration of action than other medications used to treat asthma and COPD, like salbutamol. The structure of salmeterol is similar to salbutamol, but with a different substitution on the amine. Salmeterol was approved by the FDA in 1994.
Serevent Diskusis the brand name
image of different drug pills on a surface
Serevent Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Serevent Diskus
Salmeterol
1997
77

Approved as Treatment by the FDA

Salmeterol, otherwise called Serevent Diskus, is approved by the FDA for 4 uses including Asthma and Chronic Obstructive Pulmonary Disease .
Asthma
Used to treat Asthma in combination with Fluticasone propionate
Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)
Exercise-Induced Bronchospasm
Bronchospasm, Exercise-Induced

Effectiveness

How Serevent Affects PatientsSalmeterol is an inhaled drug that works to relax the airways in the lungs, helping to make breathing easier. This drug is longer lasting than other similar drugs, however patients should be warned of potential risks such as low potassium levels or low blood sugar, and should not take it with another long-acting beta agonist.
How Serevent works in the bodySalmeterol is believed to relax the airways, allowing more air to flow through and causing bronchodilation. It does this by binding to two sites on the beta-2 adrenoceptor. The active site binds the saligenin moiety, while the exo-site binds the hydrophilic tail of salmeterol. This allows the drug to remain in the active site for a long time, making its effects last longer. It is also thought that Salmeterol diffuses into the cells' lipid layers, providing a reservoir of the drug for a longer period of time.

When to interrupt dosage

The prescribed measure of Serevent is contingent upon the diagnosed state, including Exercise-Induced Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm, Exercise-Induced. The dosage diverges, as per the administration technique shown in the table below.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Exercise-Induced Bronchospasm
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Asthma
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Bronchospasm, Exercise-Induced
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)

Warnings

Serevent Contraindications
Condition
Risk Level
Notes
primary treatment of status asthmaticus
Do Not Combine
Chronic Obstructive Airway Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Salmeterol may interact with Pulse Frequency
Not being treated with an inhaled corticosteroid
Do Not Combine
Asthma
Do Not Combine
There are 20 known major drug interactions with Serevent.
Common Serevent Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Salmeterol.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Salmeterol.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Salmeterol.
Aminophenazone
Major
The metabolism of Aminophenazone can be decreased when combined with Salmeterol.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Salmeterol.
Serevent Toxicity & Overdose RiskPeople who overdose on salmeterol may experience an acidic bloodstream, high lactic acid levels, and symptoms such as anxiety, rapid heartbeat, depression of the heart's electrical activity, low potassium, low phosphate, seizures, high or low blood pressure, headache, trembling, muscle cramps, dry mouth, nausea, fatigue, general discomfort, insomnia, and high blood sugar. Treatment may include fluids, potassium supplements, a heart-selective beta blocker, and monitoring of the heart. The exact toxic dose of salmeterol is unknown.
image of a doctor in a lab doing drug, clinical research

Serevent Novel Uses: Which Conditions Have a Clinical Trial Featuring Serevent?

At present, 244 active trials are assessing the utility of Serevent in providing relief from Exercise-Induced Bronchospasm, Bronchospasm, Exercise-Induced Dyspnea and Chronic Obstructive Pulmonary Disease (COPD).
Condition
Clinical Trials
Trial Phases
Bronchospasm, Exercise-Induced
0 Actively Recruiting
Exercise-Induced Bronchospasm
0 Actively Recruiting
Chronic Obstructive Pulmonary Disease
104 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Asthma
156 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3

Serevent Reviews: What are patients saying about Serevent?

5Patient Review
11/19/2007
Serevent for Asthma
I've been using Serevent for a decade now, and it's been incredible. Before this, I was having to use a maximum dosage of Provental or a similar medication every couple of months just to stay afloat--but since switching to Serevent, I haven't had to touch either of those things. It's really been a game-changer for me.
5Patient Review
6/27/2010
Serevent for Asthma
After using this treatment for two years, I suddenly started experiencing severe muscle cramping all over my body. Has anyone else had this problem?
5Patient Review
6/30/2011
Serevent for Asthma
This treatment is for COPD and it works. I use it twice a day, and I don't need to use my rescue inhaler more than that.
5Patient Review
10/8/2007
Serevent for Asthma
5Patient Review
11/6/2007
Serevent for Asthma
4.3Patient Review
10/27/2007
Serevent for Asthma
3.7Patient Review
3/10/2009
Serevent for Asthma
This medication helped me a lot by addressing my hacking cough and labored breathing. The only downside is that I have to take it twice a day, which can be inconvenient. Additionally, I wish the manufacturer would make the PEF online calculator more accessible.
3.3Patient Review
6/15/2009
Serevent for Asthma
This medication is pretty effective; I only have to use it once a day most of the time. There have been stretches where I've gone weeks without using it and had no asthma symptoms.
3Patient Review
3/14/2010
Serevent for Asthma
I was wondering if anyone knows if you're supposed to rinse your mouth and spit out the water after using serevent, like the directions say to do with aerobid.
2.3Patient Review
9/2/2009
Serevent for Asthma
My exercise-induced asthma and nighttime stuffy nose both saw significant improvement. I did experience a mild rash that didn't respond to hydrocortisone, but Fluocinolone Acetonide cream alleviated it. I told my doctor that, in general, being physically active and getting enough sleep makes for a happier person and patient.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about serevent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Serevent the same as Advair?

"ADVAIR contains the same medicine, salmeterol, as is found in SEREVENT DISKUS. LABA medicines, of which salmeterol is one, when used alone increase the risk of hospitalizations and death from asthma problems."

Answered by AI

Is Serevent a steroid?

"Serevent Diskus (salmeterol) is not a steroid. It belongs to the drug class called long-acting beta-agonist (LABA), which works by relaxing the muscles that allow air into your lungs. There is no need to rinse your mouth after using it."

Answered by AI

What kind of inhaler is Serevent?

"The doctor prescribed me Serevent Inhaler CFC-Free to help with my asthma. The medicine is a bronchodilator which helps to keep the airways in my lungs open. This relieves the symptoms of asthma and makes it easier for me to breathe."

Answered by AI

What is Serevent prescribed for?

"This medication is designed for long-term use in people who have difficulty breathing due to COPD. This can include emphysema and chronic bronchitis."

Answered by AI

Clinical Trials for Serevent

Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.
Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.
Have you considered Serevent clinical trials? We made a collection of clinical trials featuring Serevent, we think they might fit your search criteria.