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Bladder Transplantation for Bladder Cancer

N/A

Recruiting

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial aims to see if bladder transplantation is safe and effective for patients with terminal bladder diseases who need a new bladder or a combined kidney and bladder transplant. Participants will undergo the transplant and be monitored for

Who is the study for?

This trial is for individuals with severe bladder conditions or kidney failure who might benefit from a new bladder or both a new bladder and kidney. Participants should be in need of these transplants due to terminal diseases affecting these organs.Check my eligibility

What is being tested?

The study is testing the feasibility and safety of transplanting a human bladder alone, or together with a kidney, into patients. It will assess how well the transplanted bladder can store urine and facilitate its release over two years.See study design

What are the potential side effects?

Potential side effects may include complications related to surgery, rejection of the transplanted organ(s), infections, issues with urine storage and emptying, as well as side effects from immunosuppressive medications required after transplantation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Demonstrating the technical success of bladder or combined kidney-bladder transplantation

Secondary outcome measures

Evaluate the functionality of the transplanted bladder

Incidence of adverse events after bladder or combined kidney-bladder transplantation

Incidence of immune rejection after bladder or combined kidney-bladder transplantation

Trial Design

2Treatment groups

Experimental Treatment

Group I: Combined Kidney and Bladder TransplantationExperimental Treatment1 Intervention

Patients with terminal bladders who also have kidney failure and who qualify for the study may undergo combined kidney and bladder transplantation.

Group II: Bladder TransplantationExperimental Treatment1 Intervention

Patients with terminal bladders who do not have kidney failure and who qualify for the study may undergo bladder transplantation.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor

1,532 Previous Clinical Trials

10,265,263 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the inclusion criteria for this research study limited to individuals below the age of 50?

"Individuals aged between 18 and 70 are eligible to participate in this trial based on the set age parameters."

Answered by AI

Which criteria must individuals meet in order to be eligible for enrollment in this clinical trial?

"Candidates eligible for this trial must demonstrate a diagnosis of bladder carcinoma and fall within the age bracket of 18 to 70 years. The study has an enrollment capacity limited to 5 participants."

Answered by AI

Is the process of enrolling participants still ongoing for this medical study?

"Yes, as per clinicaltrials.gov data, this research is actively looking for subjects. The trial was first listed on April 1st, 2024, and last modified on March 22nd, 2024. It aims to enroll a total of five participants at one designated location."

Answered by AI

What is the current number of individuals actively participating in this research endeavor?

"Indeed, information on clinicaltrials.gov reveals that this research investigation is currently in search of suitable candidates. The trial was initially uploaded on April 1st, 2024 and last revised on March 22nd, 2024. A total of 5 participants are sought from a single designated site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study

Nima Nassiri 2024. "Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06337942.

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