ChatGPT for Prostate Cancer

Overseen By Zeyad Schwen, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Case Comprehensive Cancer Center

Disqualifiers: Others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether ChatGPT, a smart chatbot, can help patients better understand their prostate cancer test results. The goal is to determine if this tool can clarify medical information for those who have recently undergone a prostate biopsy but have not yet had their results explained. The trial seeks English-speaking participants who have had a prostate biopsy at the Cleveland Clinic in the last 30 days and are willing to meet in person to discuss their results. As an unphased study, this trial offers participants the chance to contribute to innovative research that could improve patient understanding of medical information.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this method is safe for helping patients understand their prostate cancer diagnosis?

Research has shown that ChatGPT is generally safe for helping prostate cancer patients understand their condition. Studies have found that ChatGPT provides good answers to common questions about prostate cancer, making it a helpful tool for patients. As a digital tool rather than a medication, ChatGPT has no reports of harmful effects or physical side effects. The main focus is on the quality of information it provides, which has been found reliable in helping patients feel more informed about their diagnosis. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike the standard treatments for prostate cancer, which usually involve surgery, radiation, or hormone therapy, the ChatGPT Prostate Pathology Guide is unique because it leverages artificial intelligence to assist in patient education and decision-making. Researchers are excited about this approach because it has the potential to provide personalized, easily understandable information to patients, helping them navigate their treatment options more effectively. This AI-driven tool could empower patients by making complex medical information more accessible, potentially improving their treatment experience and outcomes.

What evidence suggests that ChatGPT is effective for understanding prostate cancer pathology?

Research has shown that ChatGPT can greatly assist patients in understanding their prostate cancer reports. One study found that ChatGPT's accuracy matched 92% of biopsy reports and 80% of surgical pathology reports. It also aids patients in comprehending their cancer diagnosis, helping them feel more informed and in control. Additionally, ChatGPT may help predict how long patients can remain free from cancer progression. These findings suggest that ChatGPT can be a valuable tool for patients managing prostate cancer. ^{1 3 5 6 7}

Who Is on the Research Team?

Zeyad Schwen, MD

Principal Investigator

Case Comprehensive Cancer Center, Cleveland Clinic Glickman Urologic Institute

Are You a Good Fit for This Trial?

This trial is for English-speaking adults over 18 who've had a prostate biopsy at Cleveland Clinic main campus in the last 30 days without follow-up on their pathology results. They must be willing to attend an in-person review and provide informed consent.

Inclusion Criteria

Participants must be willing to attend an in-person follow-up to review their pathology

Participants must be English speaking

Participants must provide informed consent

Exclusion Criteria

Participants who do not meet the inclusion criteria, as stated above

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants interact with the ChatGPT-based chatbot to understand their prostate cancer diagnosis

70 minutes

1 visit (in-person or virtual)

Follow-up

Participants are monitored for anxiety levels and understanding of their diagnosis post-intervention

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Chat GPT

Trial Overview The study is testing whether ChatGPT, an AI-driven chatbot, can help patients better understand their prostate cancer diagnosis and pathology results.

How Is the Trial Designed?

Group I: Chat GPT - Prostate Pathology Guide Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Case Comprehensive Cancer Center

Lead Sponsor

Trials

472

Recruited

33,400+

Citations

1. nature.com nature.com/articles/s41598-025-17639-1

Evaluation of prostate cancer pathology reports generated ... In terms of accuracy, there was 92% agreement (somewhat and strongly) in the PBx report evaluations and 80% in the surgical pathology report ...

2. nature.com nature.com/articles/s41391-024-00864-6

ChatGPT can help guide and empower patients after ... Evaluation of prostate cancer pathology reports generated by ChatGPT to enhance patient comprehension. Article Open access 02 October 2025 ...

3. researchgate.net researchgate.net/publication/396130416_Evaluation_of_prostate_cancer_pathology_reports_generated_by_ChatGPT_to_enhance_patient_comprehension

Evaluation of prostate cancer pathology reports generated ... Evaluation of prostate cancer pathology reports generated by ChatGPT ... Results Data from 62 patients were analysed (30 standard vs. 32 PCR) ...

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11798939/

Evaluating ChatGPT's diagnostic potential for pathology ... This study aims to investigate the accuracy of GPT-4, which can process both text and image inputs, in generating diagnoses from pathological images.

5. onlinelibrary.wiley.com onlinelibrary.wiley.com/doi/10.1002/pros.24871

Progression‐Free Survival Prediction Performance of ... While ChatGPT has demonstrated encouraging results in forecasting the PFS duration in prostate cancer patients, the discrepancies between its ...

6. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/39141904/

Evaluating the Efficacy of ChatGPT as a Patient Education ... Our analysis found that ChatGPT-4 provides generally good responses to common prostate cancer queries, making it a potentially valuable tool ...

7. auajournals.org auajournals.org/doi/10.1097/UPJ.0000000000000740

Evaluation of ChatGPT as a Reliable Source of Medical ... The purpose of this study was the assessment of Chat Generative Pre-trained Transformer (ChatGPT) to address medical questions in prostate cancer.