Black Cumin Seed Oil for Stress

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore the potential of black cumin seed oil in managing stress levels. Researchers will examine both physical stress markers, such as cortisol, and participants' mood and well-being. Participants will receive either the oil or a placebo to compare effects. The study seeks healthy adults who feel moderately stressed and are willing to join an 8-week program without using certain medications or supplements. As an unphased trial, it offers participants the opportunity to contribute to new insights on natural stress management.

Will I have to stop taking my current medications?

Yes, if you are currently using anti-inflammatory or antidepressant medications or supplements, you will need to stop taking them at least 4 weeks before the study and during the study.

Is there any evidence suggesting that black cumin seed oil is safe for humans?

Research has shown that black cumin seed oil is generally safe for use. A recent study found that a black cumin oil product improved sleep and reduced stress, suggesting its potential safety for these purposes.

Black seed oil appears safe when taken in larger amounts for up to three months. However, reliable information on its long-term safety is lacking. Overall, it seems safe for most people when used short-term and in appropriate amounts. Always consult a healthcare provider before starting any new supplement.12345

Why are researchers excited about this trial?

Black cumin seed oil is unique because it offers a natural alternative for managing stress. Unlike typical treatments like cognitive therapy or medications such as SSRIs, this oil is derived from Nigella sativa seeds. Researchers are excited because it contains powerful compounds like thymoquinone, which may have stress-reducing properties. This approach could provide a gentler option with fewer side effects compared to traditional medications.

What evidence suggests that black cumin seed oil might be an effective treatment for stress?

Research suggests that black cumin seed oil, also known as black seed oil, may help reduce stress. One study showed that participants who took a black cumin oil extract experienced a noticeable drop in stress levels. Other research indicates that this oil can improve sleep quality, often linked to feeling less stressed. Black cumin seed oil might also boost mood and reduce anxiety. These benefits likely stem from its ability to reduce inflammation and protect cells, supporting the body's stress response. Overall, early evidence looks promising for using black cumin seed oil to manage stress. Participants in this trial will receive either a 500mg black cumin seed oil supplement or a maltodextrin placebo to evaluate its effectiveness in stress management.56789

Who Is on the Research Team?

ST

Shawn Talbott, PhD

Principal Investigator

3 Waves Wellness

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 18-70 who feel moderately stressed. They must be willing to take black cumin seed oil supplements for 8 weeks and not be on certain medications or supplements, especially anti-inflammatory or antidepressants taken in the last month. People with autoimmune diseases or those who are pregnant cannot participate.

Inclusion Criteria

I am between 18 and 70 years old and generally healthy but feel moderately stressed.
I am either female or male.
Informed consent
See 1 more

Exclusion Criteria

Inability to complete prescribed supplement regimen
Pregnancy
I haven't taken any anti-inflammatory or antidepressant medications or supplements in the last 4 weeks.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline

Baseline measurements are collected before the start of treatment

1 week
1 visit (in-person)

Treatment

Participants receive either 500mg black cumin seed oil or placebo daily

8 weeks
3 visits (in-person) at weeks 1, 4, and 8

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Black Cumin Seed Oil
Trial Overview The study tests if black cumin seed oil can help manage stress by looking at changes in saliva cortisol levels and mood states like tension, irritability, focus, fatigue, vigor, and overall well-being over an 8-week period.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: SupplementExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Shawn Talbott

Lead Sponsor

Citations

Review on Clinical Trials of Black Seed (Nigella sativa ) and ...Black seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune ...
Effect of Black Cumin Seed Oil Supplementation on ...The primary objective of this study will be to collect data to support the role of black cumin seed oil, also known as black seed oil (BSO), ...
Thymoquinone-rich black cumin oil improves sleep quality ...The results suggested a significant improvement in primary outcomes such as total sleep time, sleep latency and sleep efficiency with an increase of 82.49 % in ...
A proprietary black cumin oil extract (Nigella sativa ...PSS-14 analysis revealed a significant reduction in stress, upon both intra (p < 0.001) and inter-group (p < 0.001) comparisons. The observed reduction in ...
Neuropharmacological effects of Nigella sativa - PMCThe results of several studies have shown that this plant can improve memory impairment, anxiety, depression, epilepsy, neurotoxicity, neurodegeneration and ...
Nigella sativa (black seed) safety: an overview - PMCInvestigation of chronic toxicity found that 2 mL/kg of N. sativa fixed oil is slightly toxic. Cytotoxicity studies indicated that N. sativa ...
A phase I clinical trial to evaluate the safety of ...A recent study with black cumin oil formulation containing 5% TQ (BCO-5) exhibited significant clinical efficacy to alleviate sleep disorders and stress.
Black Seed - Uses, Side Effects, and MoreBlack seed oil and black seed powder are possibly safe when taken in larger amounts for up to 3 months. There isn't enough reliable information ...
Black Seed Oil: Health Benefits, Uses, and Side EffectsBlack seed oil may help with psoriasis, asthma, hair loss, acne, wound healing, and may aid in weight management and improve blood sugar levels.
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