Robinul Forte

Drooling, peripheral muscarinic effects, cardiac vagal inhibitory reflexes + 16 more

Treatment

20 Active Studies for Robinul Forte

Treatment for

Drooling

What is Robinul Forte

Glycopyrronium

The Generic name of this drug

Treatment Summary

Glycopyrronium, also known as NVA237 or glycopyrrolate, is a medication used to treat a wide range of conditions. It belongs to a class of medications called anticholinergics. In the past, it has been used to treat peptic ulcers, but it can also be used to reduce sweat gland, oral, airway, and gastric secretions, reduce cardiac inhibitory reflexes, and reduce bronchoconstriction in patients with chronic obstructive pulmonary disease. Glycopyrronium was approved by the FDA in 1961 and is a commonly prescribed first-line treatment for many

Robinul

is the brand name

image of different drug pills on a surface

Robinul Forte Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Robinul

Glycopyrronium

1961

294

Effectiveness

How Robinul Forte Affects Patients

Glycopyrronium is a drug used to block the action of a certain nerve receptor, which produces a long-lasting effect. It is considered to be a safer drug than other similar medications, and patients should be warned about side effects such as the potential for increased urinary retention, overheating, and temporary blurred vision.

How Robinul Forte works in the body

Glycopyrronium is a drug that blocks the effects of muscarinic receptors, which are proteins in the body that cause certain reactions. In the lungs, muscarinic receptors can lead to bronchoconstriction and increased airway secretions. Blocking these receptors with glycopyrronium reduces the amount of secretions. In the gastrointestinal system, it reduces stomach acidity and the amount of saliva and sweat produced. Finally, in the cardiovascular system, it prevents the vagal nerve from slowing down the heart rate.

When to interrupt dosage

The quantity of Robinul Forte is contingent upon the determined condition, including Peptic Ulcer, Neurological Conditions and Drooling. The measure of dosage fluctuates based on the delivery approach (e.g. Capsule - Respiratory (inhalation) or Aerosol, metered) featured in the following table.

Condition

Dosage

Administration

Drooling

, 1.0 mg, 2.0 mg, 0.2 mg/mL, 1.5 mg, 0.05 mg, 0.044 mg, 0.32 mg/mL, 1.0 mg/mL, 0.009 mg, 0.4 mg/mL, 0.0156 mg, 0.025 mg/mL, 0.024 mg/mg, 0.5 mg/mL, 0.0072 mg, 0.043 mg, 0.046 mg, 0.0083 mg/pump actuation, 0.0082 mg/pump actuation, 1.7 mg

, Oral, Tablet - Oral, Tablet, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Oral, Liquid - Oral, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Intramuscular; Intravenous, Cloth - Topical, Cloth, Topical, Injection, solution - Intramuscular; Intravitreal, Intramuscular; Intravitreal, Aerosol - Respiratory (inhalation), Aerosol, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Increased upper airway secretion

Induction of anesthesia therapy

Choking

Bronchitis, Chronic

Peptic Ulcer

General Surgery

Cerebral Palsy

Hyperhidrosis disorder

Oral cavity

Anticholinergic Syndrome

Reflex, Trigeminocardiac

Chronic Obstructive Pulmonary Disease

peripheral muscarinic effects

cardiac vagal inhibitory reflexes

Bodily secretions

Emphysema

Neurological Conditions

Warnings

Robinul Forte has twelve acknowledged contraindications, so it should be avoided in situations where any of the conditions in the following table are present.

Robinul Forte Contraindications

Condition

Risk Level

Notes

Ulcerative Colitis

Do Not Combine

Uterine Inertia

Do Not Combine

Ulcerative Colitis

Do Not Combine

Myasthenia Gravis

Do Not Combine

Arterial Occlusive Diseases

Do Not Combine

Cardiovascular Physiological Phenomena

Do Not Combine

Pulse Frequency

Do Not Combine

Therapeutic procedure

Do Not Combine

Intestinal Pseudo-Obstruction

Do Not Combine

Open-angle glaucoma

Do Not Combine

Uropathy Obstructive

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Glycopyrronium may interact with Pulse Frequency

There are 20 known major drug interactions with Robinul Forte.

Common Robinul Forte Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Aclidinium.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Cimetropium.

Eluxadoline

Major

The risk or severity of constipation can be increased when Glycopyrronium is combined with Eluxadoline.

Macimorelin

Major

The therapeutic efficacy of Macimorelin can be decreased when used in combination with Glycopyrronium.

Secretin human

Major

The therapeutic efficacy of Secretin human can be decreased when used in combination with Glycopyrronium.

Robinul Forte Toxicity & Overdose Risk

Symptoms of an overdose on atropine may include flushing, fever, fast heart rate, a slow digestive system, difficulty urinating, sensitivity to light, dilated pupils, nausea, vomiting, dizziness, feeling lightheaded, and constipation. The lowest toxic dose in mice is 570mg/kg and in rats is 709mg/kg when ingested orally. When administered intraperitoneally, the lowest toxic dose in mice is 90mg/kg and in rats is 196mg/kg. For treatment, patients should be given supportive and symptomatic therapy, which may include the use of catheters, cardiovascular support,

image of a doctor in a lab doing drug, clinical research

Robinul Forte Novel Uses: Which Conditions Have a Clinical Trial Featuring Robinul Forte?

164 active studies are in progress to assess the potential of Robinul Forte to ameliorate Chronic Obstructive Pulmonary Disease (COPD), cardiac vagal inhibitory reflexes and General Surgery.

Condition

Clinical Trials

Trial Phases

Chronic Obstructive Pulmonary Disease

77 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Choking

4 Actively Recruiting

Not Applicable

General Surgery

2 Actively Recruiting

Not Applicable

Hyperhidrosis disorder

0 Actively Recruiting

Increased upper airway secretion

0 Actively Recruiting

Anticholinergic Syndrome

0 Actively Recruiting

Induction of anesthesia therapy

0 Actively Recruiting

Reflex, Trigeminocardiac

0 Actively Recruiting

Emphysema

4 Actively Recruiting

Phase 2, Not Applicable

Oral cavity

0 Actively Recruiting

peripheral muscarinic effects

0 Actively Recruiting

Reflex, Trigeminocardiac

0 Actively Recruiting

Drooling

0 Actively Recruiting

Neurological Conditions

1 Actively Recruiting

Not Applicable

Bronchitis, Chronic

0 Actively Recruiting

cardiac vagal inhibitory reflexes

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Bodily secretions

0 Actively Recruiting

Cerebral Palsy

0 Actively Recruiting

Robinul Forte Reviews: What are patients saying about Robinul Forte?

Patient Review

1/10/2011

Robinul Forte for Irritable Colon

This treatment has been life-changing for me. I've suffered from excessive sweating for years, and tried all sorts of treatments with no success. But this medication has really helped. I only need to take it every other day, and the only side effect I've noticed is that my nails get a little brittle sometimes.

Patient Review

2/22/2010

Robinul Forte for Irritable Colon

So far, this medication has effectively helped with both my sweating and my irritable bowel syndrome.

Patient Review

9/7/2009

Robinul Forte for Diarrhea

4.7

Patient Review

2/11/2010

Robinul Forte for Irritable Colon

I tried this treatment for excessive sweating, but it didn't work at all. It did help with my irritable bowel syndrome (IBS), though I became a little constipated.

Patient Review

6/2/2013

Robinul Forte for Irritable Colon

This medication has caused me a great deal of trouble swallowing. My mouth is so dry that the pills often get stuck in my throat.

Patient Review

8/25/2014

Robinul Forte for Irritable Colon

I tried Robinul for my IBS and it made me nauseous, vomit, and taste bile all the time. The dry mouth and anxiety attacks were new symptoms that arose after starting to take this medication. discontinuing use of Robinul made my vomiting worse than it was before.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about robinul forte

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Robinul used for?

"Glycopyrrolate belongs to a class of drugs known as anticholinergics/antispasmodics.

Glycopyrrolate is used in conjunction with other drugs to ameliorate a specific type of gastrointestininal ulcer (peptic ulcer). This medication has a high chance of relieving stomach/abdominal pain. Glycopyrrolate is classified as a drug belonging to the group of anticholinergics/antispasmodics."

Answered by AI

Does Robinul make you sleepy?

"or headache

If you experience any of the following side effects, contact your doctor immediately:constipation, nausea, vomiting, bloating; drowsiness, dizziness, weakness, feeling nervous; slow heartbeats; sleep problems (insomnia); or headache."

Answered by AI

How does Robinul work for sweating?

"Robinul reduces the amount of sweat, saliva, and other secretions in the body."

Answered by AI

Is Robinul used for IBS?

"Antispasmodics may also be found in some over-the-counter medications. Antidiarrheals work to slow or stop intestinal contractions. Loperamide (Imodium) is an antidiarrheal that is also available without a prescription

Antispasmodics are drugs that help to relax intestinal contractions, and can be useful in treating IBS. Some examples of antispasmodics include dicyclomine, hyoscyamine, belladonna, clindex, and glycopyrrolate. These drugs may be available by prescription or over the counter. Antidiarrheals are drugs that work to slow or stop intestinal contractions. One example of an antidiarrheal is loperamide, which is available without a prescription."

Answered by AI

Clinical Trials for Robinul Forte

Image of Stanford University in Stanford, United States.

MoblO2 for Chronic Lung Diseases

18+

All Sexes

Stanford, CA

Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); 3) that it will stave off putative complications of hypoxemia (e.g., cognitive dysfunction, pulmonary hypertension) and 4) that it will improve health-related quality of life (HRQL). However, despite the rationale for O2, and prescribers' good intentions, patients generally view O2 with frustration and fear - it threatens their HRQL, which is already impaired by having a condition that imposes itself on every aspect of their lives. Nasal cannulas and delivery devices call unwanted attention to patients when they are out in public. O2 users feel stigmatized and are often viewed as "smokers who get what they deserve, even if they never smoked a day in their lives" - or as disabled, sick or even infectious. O2 steals patients' independence, forcing them to plan their lives around it. The anxiety that patients and their caregivers experience around running out of oxygen, or not getting enough, immobilizes them and restricts participation in activities outside of the home. O2 disrupts the home environment, adding stress, and creating a burden for patients' caregiver-loved-ones who are often saddled with the responsibility of ensuring adequate equipment and supply of O2, and O2 is a constant reminder to patients they are living with a condition that could shorten their lives. O2 delivery equipment is typically heavy, unwieldy and intimidating. Different recommendations (e.g., insurance companies use 88% as a cut-off for SpO2, while many practitioners focus on 90%) make it confusing for patients, which almost certainly affects adherence. O2-requiringpatients are starving for things that can make their lives easier. An auto-adjusting O2 delivery device - one that automatically delivers the correct amount of O2 to maintain blood oxygen at desired, pre-set levels - would alleviate the need for patients to constantly (incessantly for many) monitor their peripheral oxygen saturation (SpO2) and adjust O2flow to meet the demands as exertion levels vary . The MoblO2 device is a battery-operated, light-weight, closed-loop O2 delivery device that houses a regulator (which attaches to compressed gas O2 tanks) and adjusts O2 flow to meet a pre-set blood oxygen level. A pulse oximeter is worn on the ear and transmits via Bluetooth to the device, which adjusts an internal valve to control flow on a second-to-second basis. The user sets the dial to the highest flow of O2 needed to meet the demands of activities they might perform (up to 15 liters per minute), and the device adjusts flow, up to the pre-set level to maintain SpO2 at a preset level (e.g., \> 90%). To conserve O2 supply in the tank - and to avoid over-oxygenation (which could be problematic for a small percentage of patients with the most severe COPD) - the MoblO2 begins to limit O2 flow at a SpO2 of 93%. The device can be manually over-ridden by the user, and should the battery run out - or the device fail for some unforeseen reason - the default position is valve open, so the users receive whatever flow of oxygen has been set on the dial. Given the substantial burdens of O2 on patients and their families, the hassles patients describe with having to monitor their SpO2 and repeatedly adjust the flow of O2 to meet their needs, patients and experts around the world have called for improvements in O2 delivery equipment. The MoblO2 is just such a remarkable improvement and a giant step forward in helping to ease the burdens of O2 on patients who require it. The purpose of this study is to investigate the effects of the MoblO2 O2 delivery device on a range of outcomes, including physical activity, amount (liters) O2 use; maintenance of adequate SpO2 levels; patient reported outcomes including symptoms, HRQL and satisfaction with the MoblO2 O2 device.

Waitlist Available

Has No Placebo

Stanford University

Jeff Swigris, DO, MS

Minnesota Health Solutions