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What is Riomet
MetforminThe Generic name of this drug
Treatment SummaryMetformin is a medication used to treat type 2 diabetes. It works by reducing blood sugar levels without causing hypoglycemia (low blood sugar). It also helps to improve insulin sensitivity, lower fasting insulin levels, and can lead to modest weight loss. Metformin was first approved in Canada in 1972 and in the USA in 1995, and is available in regular and extended-release forms. It is the most commonly prescribed drug for type 2 diabetes, with more than 120 million people taking it worldwide.
Metformin Hydrochlorideis the brand name
Riomet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Metformin Hydrochloride
Metformin
2002
1263
Approved as Treatment by the FDA
Metformin, otherwise known as Metformin Hydrochloride, is approved by the FDA for 16 uses which include Congestive Heart Failure and Physical Activity .Congestive Heart Failure
Used to treat Heart Failure in combination with Dapagliflozin
Physical Activity
Used to treat Exercise in combination with Dapagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Dapagliflozin
Hospitalizations
Used to treat Hospitalizations in combination with Dapagliflozin
Diet
Used to treat Diet in combination with Dapagliflozin
Type 1 Diabetes
Used to treat Type 1 Diabetes Mellitus in combination with Sitagliptin
Chronic Kidney Disease
Used to treat Chronic Kidney Disease (CKD) in combination with Dapagliflozin
NYHA Functional Class II-IV Heart Failure
Used to treat NYHA Functional Class II-IV Heart Failure in combination with Dapagliflozin
Ejection fraction decreased
Used to treat Ejection fraction decreased in combination with Dapagliflozin
Diabetic Ketoacidosis
Used to treat Diabetic Ketoacidosis in combination with Saxagliptin
uncontrolled diabetes
Used to treat uncontrolled diabetes in combination with Rosiglitazone
Cardiovascular Disease
Used to treat Cardiovascular Risk in combination with Dapagliflozin
Cardiovascular Diseases
Used to treat established cardiovascular disease in combination with Dapagliflozin
decreased estimated glomerular filtration rate
Used to treat decreased estimated glomerular filtration rate in combination with Dapagliflozin
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Dapagliflozin
Kidney Failure
Used to treat End Stage Renal Disease (ESRD) in combination with Dapagliflozin
Effectiveness
How Riomet Affects PatientsInsulin is a hormone that helps control blood sugar levels. People with type 2 diabetes have decreased sensitivity to insulin, which leads to higher blood sugar levels. Metformin works by reducing the amount of sugar made by the liver, stopping sugar from being absorbed by the gut, and making the body more sensitive to insulin. Metformin does not cause too much insulin to be released like some other diabetes drugs, but it can still help lower blood sugar levels. In a 29 week study of people with type 2 diabetes, taking metformin lowered fasting blood sugar by an average of 59 mg/dL and lowered glycosylated hemoglobin
How Riomet works in the bodyMetformin works in the body to help control blood sugar levels in people with type 2 diabetes. It does this by decreasing the amount of sugar produced by the liver, reducing the amount of sugar absorbed in the intestines, and increasing the body's sensitivity to insulin. When metformin enters the body, it is taken up by the liver cells and accumulates in the mitochondria. This leads to a decrease in the production of energy, which activates an enzyme called AMPK. Activated AMPK then helps to reduce fat synthesis and glucose production, while also helping the body use glucose more effectively. In the intestines, metform
When to interrupt dosage
The proposed measure of Riomet is contingent upon the established condition, including Diet, inadequate answer to metformin and Diabetic Ketoacidosis. The quantity of dosage fluctuates as per the delivery approach (e.g. Oral or Tablet - Oral) listed in the table underneath.Condition
Dosage
Administration
decreased estimated glomerular filtration rate
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Diabetic Ketoacidosis
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Type 1 Diabetes
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Polycystic Ovarian Syndrome
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Congestive Heart Failure
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Physical Activity
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Type 2 Diabetes
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Chronic Kidney Disease
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Kidney Failure
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Diet
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Hospitalizations
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Cardiovascular Disease
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Cardiovascular Mortality
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
inadequate response to metformin
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Ejection fraction decreased
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
NYHA Functional Class II-IV Heart Failure
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Cardiovascular Diseases
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
uncontrolled diabetes
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
diet and exercise not sufficient for diabetes control
500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg
Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated - Oral, Tablet, coated, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral
Warnings
Riomet has twenty contraindications and should not be administered simultaneously with the conditions outlined in the following table.Riomet ContraindicationsCondition
Risk Level
Notes
severe hepatic dysfunction
Do Not Combine
Impaired Renal Function
Do Not Combine
cardiovascular collapse
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Operative Surgery
Do Not Combine
Metabolic acidosis
Do Not Combine
cardiorespiratory insufficiency caused by Heart Failure
Do Not Combine
Impaired Renal Function
Do Not Combine
kidney function unknown
Do Not Combine
Hypovolemic Shock
Do Not Combine
serum creatinine above upper limit for age range
Do Not Combine
ethanol
Do Not Combine
Acute Coryza
Do Not Combine
Hypoxemia
Do Not Combine
Liver Failure
Do Not Combine
Lactic Acidosis
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Impaired Renal Function
Do Not Combine
estimated GFR <30mL/min
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Metformin may interact with Pulse Frequency
Common Riomet Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Metformin.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Metformin.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Metformin.
Abacavir
Minor
Metformin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Metformin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Riomet Toxicity & Overdose RiskThe toxic dose of Metformin (hydrochloride) for rats is 1g/kg orally, 500mg/kg intraperitoneally, and 300mg/kg subcutaneously. For mice, the toxic dose is 1450mg/kg orally, 420mg/kg intraperitoneally, and 225mg/kg subcutaneously. Taking too much Metformin may increase the risk of lactic acidosis, which can cause symptoms such as malaise, muscle pain, abdominal pain, and difficulty breathing. Metformin should be avoided in those with severely impaired kidney function, acute or decompensated heart
Riomet Novel Uses: Which Conditions Have a Clinical Trial Featuring Riomet?
A total of 346 active clinical trials are being conducted to assess the potential of Riomet in treating Type 2 Diabetes, Type 1 Diabetes and inadequate response to metformin therapy.Condition
Clinical Trials
Trial Phases
Type 1 Diabetes
146 Actively Recruiting
Phase 3, Phase 1, Early Phase 1, Not Applicable, Phase 2, Phase 4
inadequate response to metformin
0 Actively Recruiting
Cardiovascular Disease
31 Actively Recruiting
Not Applicable, Phase 1, Early Phase 1, Phase 3, Phase 2
Polycystic Ovarian Syndrome
9 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4
Type 2 Diabetes
193 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Chronic Kidney Disease
115 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Diabetic Ketoacidosis
3 Actively Recruiting
Phase 2, Early Phase 1, Not Applicable
decreased estimated glomerular filtration rate
0 Actively Recruiting
Kidney Failure
54 Actively Recruiting
Phase 3, Phase 1, Phase 2, Phase 4, Not Applicable
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Diet
5 Actively Recruiting
Not Applicable
uncontrolled diabetes
0 Actively Recruiting
NYHA Functional Class II-IV Heart Failure
0 Actively Recruiting
Ejection fraction decreased
0 Actively Recruiting
Hospitalizations
2 Actively Recruiting
Not Applicable
Cardiovascular Diseases
0 Actively Recruiting
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Cardiovascular Mortality
0 Actively Recruiting
diet and exercise not sufficient for diabetes control
0 Actively Recruiting
Riomet Reviews: What are patients saying about Riomet?
4.3Patient Review
10/8/2008 This medication has been great for me. It's helped a lot with my diabetes pills, which I had a hard time swallowing before. My body got used to it quickly and I haven't experienced any negative side effects.
4.3Patient Review
5/17/2009 I have trouble swallowing pills, so my doctor recommended this treatment to me as an alternative to Metformin. So far, it's been great! I haven't had any issues when taking it with a meal or snack.
3.7Patient Review
10/22/2010 I was reading about potential side effects today and realized that some of the things I've been experiencing may be due to the medication. Also, as of today, the manufacturer is not producing the liquid form of Metformin due to "production problems." I can't swallow the big pills and need the liquid form, but now it might not be available until June!
2.7Patient Review
3/9/2016 The flavor is incredibly off-putting. I'd recommend speaking to your pharmacist about adding a mango flavoring - it really helped me get the medicine down without gagging.
1.3Patient Review
7/3/2008 Unfortunately, this medication caused me a lot of digestive problems.
Patient Q&A Section about riomet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Riomet used for?
"The drug is used to help control blood sugar levels in patients with type 2 diabetes. Managing blood sugar can help prevent serious diabetes-related problems, such as kidney damage, blindness, nerve damage, limb loss, and sexual dysfunction. Keeping diabetes under control may also reduce your risk of heart attack and stroke."
Answered by AI
Is Riomet available in the US?
"Riomet ER was approved by the U.S. Food and Drug Administration (FDA) to be taken once daily. It is the first and only FDA-approved liquid formulation of extended-release metformin."
Answered by AI
Is Riomet the same as metformin?
"Riomet is a prescription medication used to treat the symptoms of Type 2 diabetes. It may be used alone or with other medications. Riomet belongs to a class of drugs called Antidiabetics, Biguanides."
Answered by AI
What type of medication is Riomet?
"Riomet is a medication used to control blood sugar in patients with type 2 diabetes. It is to be used with a proper diet and exercise program, and possibly with other medications."
Answered by AI