Riomet

Diabetic Ketoacidosis, Congestive Heart Failure, Type 1 Diabetes + 16 more

Treatment

22 FDA approvals

20 Active Studies for Riomet

What is Riomet

Metformin

The Generic name of this drug

Treatment Summary

Metformin is a medication used to treat type 2 diabetes. It works by reducing blood sugar levels without causing hypoglycemia (low blood sugar). It also helps to improve insulin sensitivity, lower fasting insulin levels, and can lead to modest weight loss. Metformin was first approved in Canada in 1972 and in the USA in 1995, and is available in regular and extended-release forms. It is the most commonly prescribed drug for type 2 diabetes, with more than 120 million people taking it worldwide.

Metformin Hydrochloride

is the brand name

Riomet Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Metformin Hydrochloride

Metformin

2002

1263

Approved as Treatment by the FDA

Metformin, otherwise known as Metformin Hydrochloride, is approved by the FDA for 22 uses which include Heart Failure and Heart Failure .

Heart Failure

Used to treat NYHA Functional Class II-IV Heart Failure in combination with Dapagliflozin

Heart Failure

Used to treat Heart Failure in combination with Dapagliflozin

Kidney Failure

Used to treat End Stage Renal Disease (ESRD) in combination with Dapagliflozin

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Dapagliflozin

Chronic Kidney Disease

Used to treat Chronic Kidney Disease (CKD) in combination with Dapagliflozin

Renal Insufficiency

Used to treat decreased estimated glomerular filtration rate in combination with Dapagliflozin

Ejection fraction decreased

Used to treat Ejection fraction decreased in combination with Dapagliflozin

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Dapagliflozin

Ketosis

Used to treat Diabetic Ketoacidosis in combination with Saxagliptin

Diet

Used to treat Diet in combination with Dapagliflozin

Hospitalizations

Used to treat Hospitalizations in combination with Dapagliflozin

Congestive Heart Failure

Used to treat Heart Failure in combination with Dapagliflozin

Physical Activity

Used to treat Exercise in combination with Dapagliflozin

Chronic Kidney Disease (CKD)

Used to treat Chronic Kidney Disease (CKD) in combination with Dapagliflozin

Type 1 Diabetes Mellitus

Used to treat Type 1 Diabetes Mellitus in combination with Sitagliptin

Diabetic Ketoacidosis

Used to treat Diabetic Ketoacidosis in combination with Saxagliptin

Cardiovascular Mortality

Used to treat Cardiovascular Mortality in combination with Dapagliflozin

Diabetes Mellitus

Used to treat uncontrolled diabetes in combination with Rosiglitazone

Cardiovascular Disease

Used to treat Cardiovascular Risk in combination with Dapagliflozin

Cardiovascular Diseases

Used to treat established cardiovascular disease in combination with Dapagliflozin

Heart failure

Used to treat Heart Failure in combination with Dapagliflozin

Type 1 Diabetes

Used to treat Type 1 Diabetes Mellitus in combination with Sitagliptin

Effectiveness

How Riomet Affects Patients

Insulin is a hormone that helps control blood sugar levels. People with type 2 diabetes have decreased sensitivity to insulin, which leads to higher blood sugar levels. Metformin works by reducing the amount of sugar made by the liver, stopping sugar from being absorbed by the gut, and making the body more sensitive to insulin. Metformin does not cause too much insulin to be released like some other diabetes drugs, but it can still help lower blood sugar levels. In a 29 week study of people with type 2 diabetes, taking metformin lowered fasting blood sugar by an average of 59 mg/dL and lowered glycosylated hemoglobin

How Riomet works in the body

Metformin works in the body to help control blood sugar levels in people with type 2 diabetes. It does this by decreasing the amount of sugar produced by the liver, reducing the amount of sugar absorbed in the intestines, and increasing the body's sensitivity to insulin. When metformin enters the body, it is taken up by the liver cells and accumulates in the mitochondria. This leads to a decrease in the production of energy, which activates an enzyme called AMPK. Activated AMPK then helps to reduce fat synthesis and glucose production, while also helping the body use glucose more effectively. In the intestines, metform

When to interrupt dosage

The proposed measure of Riomet is contingent upon the established condition, including Diet, inadequate answer to metformin and Diabetic Ketoacidosis. The quantity of dosage fluctuates as per the delivery approach (e.g. Oral or Tablet - Oral) listed in the table underneath.

Condition

Dosage

Administration

Cardiovascular Diseases

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

inadequate response to metformin

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Insulin Resistance

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Renal Insufficiency

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Diabetes Mellitus

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Congestive Heart Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Type 2 Diabetes

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Chronic Kidney Disease

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Diabetic Ketoacidosis

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Physical Activity

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Kidney Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Diet

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Hospitalizations

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Heart Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Type 1 Diabetes

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Polycystic Ovarian Syndrome

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Cardiovascular Disease

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Cardiovascular Mortality

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Ejection fraction decreased

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release - Oral, For suspension, extended release, Kit - Oral

Warnings

Riomet has twenty contraindications and should not be administered simultaneously with the conditions outlined in the following table.

Riomet Contraindications

Condition

Risk Level

Notes

Liver Failure

Do Not Combine

Renal Insufficiency

Do Not Combine

Heart Arrest

Do Not Combine

Diabetic Ketoacidosis

Do Not Combine

Operative Surgery

Do Not Combine

Metabolic acidosis

Do Not Combine

Heart Failure

Do Not Combine

Renal Insufficiency

Do Not Combine

kidney function unknown

Do Not Combine

Hypovolemic Shock

Do Not Combine

serum creatinine above upper limit for age range

Do Not Combine

ethanol

Do Not Combine

Acute Coryza

Do Not Combine

Hypoxemia

Do Not Combine

Liver Failure

Do Not Combine

Acidosis, Lactic

Do Not Combine

Diabetic Ketoacidosis

Do Not Combine

Renal Insufficiency

Do Not Combine

Renal Insufficiency, Chronic

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Metformin may interact with Pulse Frequency

There are 20 known major drug interactions with Riomet.

Common Riomet Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The excretion of Abemaciclib can be decreased when combined with Metformin.

Procainamide

Major

The excretion of Procainamide can be decreased when combined with Metformin.

Topotecan

Major

The excretion of Topotecan can be decreased when combined with Metformin.

Abacavir

Minor

Metformin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Metformin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Riomet Toxicity & Overdose Risk

The toxic dose of Metformin (hydrochloride) for rats is 1g/kg orally, 500mg/kg intraperitoneally, and 300mg/kg subcutaneously. For mice, the toxic dose is 1450mg/kg orally, 420mg/kg intraperitoneally, and 225mg/kg subcutaneously. Taking too much Metformin may increase the risk of lactic acidosis, which can cause symptoms such as malaise, muscle pain, abdominal pain, and difficulty breathing. Metformin should be avoided in those with severely impaired kidney function, acute or decompensated heart

image of a doctor in a lab doing drug, clinical research

Riomet Novel Uses: Which Conditions Have a Clinical Trial Featuring Riomet?

A total of 346 active clinical trials are being conducted to assess the potential of Riomet in treating Type 2 Diabetes, Type 1 Diabetes and inadequate response to metformin therapy.

Condition

Clinical Trials

Trial Phases

Chronic Kidney Disease

96 Actively Recruiting

Phase 1, Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1

Cardiovascular Diseases

0 Actively Recruiting

Congestive Heart Failure

187 Actively Recruiting

Not Applicable, Phase 1, Early Phase 1, Phase 2, Phase 3, Phase 4

Type 1 Diabetes

119 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 1, Phase 4

Cardiovascular Disease

29 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Type 2 Diabetes

181 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Kidney Failure

43 Actively Recruiting

Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Physical Activity

29 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Insulin Resistance

0 Actively Recruiting

Renal Insufficiency

0 Actively Recruiting

Cardiovascular Mortality

0 Actively Recruiting

Ejection fraction decreased

0 Actively Recruiting

Hospitalizations

1 Actively Recruiting

Not Applicable

Diabetic Ketoacidosis

1 Actively Recruiting

Phase 1, Phase 2

Polycystic Ovarian Syndrome

7 Actively Recruiting

Not Applicable, Phase 1

inadequate response to metformin

0 Actively Recruiting

Heart Failure

0 Actively Recruiting

Diet

7 Actively Recruiting

Not Applicable, Phase 1

Diabetes Mellitus

0 Actively Recruiting

Riomet Reviews: What are patients saying about Riomet?

4.3

Patient Review

10/8/2008

Riomet for Type 2 Diabetes Mellitus

This medication has been great for me. It's helped a lot with my diabetes pills, which I had a hard time swallowing before. My body got used to it quickly and I haven't experienced any negative side effects.

4.3

Patient Review

5/17/2009

Riomet for Type 2 Diabetes Mellitus

I have trouble swallowing pills, so my doctor recommended this treatment to me as an alternative to Metformin. So far, it's been great! I haven't had any issues when taking it with a meal or snack.

3.7

Patient Review

10/22/2010

Riomet for Type 2 Diabetes Mellitus

I was reading about potential side effects today and realized that some of the things I've been experiencing may be due to the medication. Also, as of today, the manufacturer is not producing the liquid form of Metformin due to "production problems." I can't swallow the big pills and need the liquid form, but now it might not be available until June!

2.7

Patient Review

3/9/2016

Riomet for Type 2 Diabetes Mellitus

The flavor is incredibly off-putting. I'd recommend speaking to your pharmacist about adding a mango flavoring - it really helped me get the medicine down without gagging.

1.3

Patient Review

7/3/2008

Riomet for Type 2 Diabetes Mellitus

Unfortunately, this medication caused me a lot of digestive problems.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about riomet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Riomet used for?

"The drug is used to help control blood sugar levels in patients with type 2 diabetes. Managing blood sugar can help prevent serious diabetes-related problems, such as kidney damage, blindness, nerve damage, limb loss, and sexual dysfunction. Keeping diabetes under control may also reduce your risk of heart attack and stroke."

Answered by AI

Is Riomet available in the US?

"Riomet ER was approved by the U.S. Food and Drug Administration (FDA) to be taken once daily. It is the first and only FDA-approved liquid formulation of extended-release metformin."

Answered by AI

Is Riomet the same as metformin?

"Riomet is a prescription medication used to treat the symptoms of Type 2 diabetes. It may be used alone or with other medications. Riomet belongs to a class of drugs called Antidiabetics, Biguanides."

Answered by AI

What type of medication is Riomet?

"Riomet is a medication used to control blood sugar in patients with type 2 diabetes. It is to be used with a proper diet and exercise program, and possibly with other medications."

Answered by AI

Clinical Trials for Riomet

Image of Institut de recherches cliniques de Montréal (IRCM) in Montreal, Canada.

Fish Oil for Type 2 Diabetes

40 - 70
All Sexes
Montreal, Canada

The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes. Some metabolic problems-such as difficulty controlling blood sugar, unhealthy particles that transport cholesterol in the blood, and poor fat tissue function-can increase the risk of type 2 diabetes. This study aims to determine whether different types of fish oil can: 1. Improve how well the body produces insulin and responds to it, 2. Improve the quality of the particles that carry "bad" cholesterol in the blood, and 3) Improve the health and function of participants' fat tissue. To answer these questions, researchers will compare the effects of two types of fish oil: EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). These will be compared with corn oil, which is used as a placebo and does not contain EPA or DHA. When included in this study, participants will: A) Take softgel capsules containing EPA, DHA, or placebo (corn oil) every day for 12 weeks, B) Keep a daily log to record when they take their study softgels, and C) Visit the research unit six times, including one and a half days before and after the intervention, to complete specialized metabolic tests that are mostly only available in research settings.

Phase 2
Waitlist Available

Institut de recherches cliniques de Montréal (IRCM)

May Faraj, P.Dt., Ph.D.

Image of Centre de recherche du CHUS in Sherbrooke, Canada.

Cold Exposure for Type 2 Diabetes

40 - 75
All Sexes
Sherbrooke, Canada

Type 2 Diabetes Mellitus (T2DM) is a widespread health condition characterized by impaired ability of the body to maintain glucose homeostasis. This impairment often leads to secondary complications, including heart disease, high blood pressure, and poor quality of life. While exercise and healthy eating are effective strategies in managing and preventing T2DM, data shows that long-term adherence to these methods are poor - especially among elderly, individuals with obesity and/or with physical limitations. This clinical study explores cold exposure with shivering as a novel strategy to improve blood sugar control and heart health. In earlier research, spending time in mildly cold environments (around 15-17°C) for a few hours a day improved insulin sensitivity of T2DM patients. Interestingly, these benefits only occurred when the cold caused mild shivering. In a recent 10-day cold acclimation study with overt shivering for minimally 1 hour/day, we observed improved glucose tolerance in participants with overweight/obesity, as well as improved fasting lipid profiles. These results indicate that when accompanied with sufficient level of muscle activation, repeated exposure to cold can beneficially affect both glucose and lipid levels - both of which are impaired in people with T2DM. In this study, we hypothesise that a 10-day cold acclimation with shivering will improve the (peripheral) insulin sensitivity of patients with T2DM, accompanied by enhanced skeletal muscle FA uptake and oxidation as assessed via the 11C palmitate uptake.

Recruiting
Has No Placebo

Centre de recherche du CHUS

Denis P. Blondin, PhD

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Image of Advanced Cardiovascular, LLC in Alexander City, United States.

NNC0487-0111 for Obesity and Heart Failure

18+
All Sexes
Alexander City, AL

This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.

Phase 3
Waitlist Available

Advanced Cardiovascular, LLC (+99 Sites)

Clinical Transparency (dept. 2834)

Novo Nordisk A/S

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Image of Baylor Scott and White Medical Center- Temple in Temple, United States.

Rapid Treatment Approach for Chronic Kidney Disease

18 - 84
All Sexes
Temple, TX

The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease. The main questions it aims to answer are: * Is it safe to start these medicines over a short period of time? * How often do kidney function changes or high potassium levels occur? * Does this approach lower protein in the urine (a sign of kidney damage)? * How many participants are able to stay on all four medicines over 6 months? Researchers will compare this approach to usual care, where medicines are started one at a time over several months. Participants will: Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months

Phase 4
Waitlist Available

Baylor Scott and White Medical Center- Temple

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We made a collection of clinical trials featuring Riomet, we think they might fit your search criteria.
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