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What is Prozac Weekly
FluoxetineThe Generic name of this drug
Treatment SummaryFluoxetine is an antidepressant medication that belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It was approved by the FDA in 1987 and is used today to treat depression and other mental health issues.
Prozacis the brand name
Prozac Weekly Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prozac
Fluoxetine
1987
490
Approved as Treatment by the FDA
Fluoxetine, also known as Prozac, is approved by the FDA for 3 uses such as Depression and Bipolar Disorder .Depression
Used to treat Depression in combination with Olanzapine
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine
Effectiveness
How Prozac Weekly Affects PatientsFluoxetine works by blocking the transporter that absorbs serotonin. This leads to higher levels of serotonin in certain parts of the brain. Fluoxetine doesn't bind very easily to other receptors such as dopamine, adrenaline, and serotonin, which is why it has fewer side effects than other types of antidepressants like tricyclic antidepressants.
How Prozac Weekly works in the bodyIn 1965, scientists found that depression may be linked to changes in brain chemicals like noradrenaline and serotonin. To address this, a drug called fluoxetine was created. Fluoxetine works by blocking the reuptake of serotonin. This causes serotonin levels to increase in the brain. It also has a weak connection with noradrenaline transporters, so it can help boost these levels too. Fluoxetine also interacts with the 5-HT2C receptor, which can further increase levels of noradrenaline and dopamine in the prefrontal cortex.
When to interrupt dosage
The proposed dosage of Prozac Weekly is contingent upon the diagnosed condition, including Myoclonus, Bipolar Disorder and Unipolar Depression. Dosage likewise fluctuates per the procedure of delivery (e.g. Tablet, coated or Oral) delineated in the table beneath.Condition
Dosage
Administration
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Premature Ejaculation
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bulimia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Myoclonus
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Cataplexy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Anorexia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bipolar Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Obsessive-Compulsive Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
maintenance therapy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Panic Disorder (With or Without Agoraphobia)
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Unipolar Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
moderate to severe symptoms
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alcoholism
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Prozac Weekly ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Prozac Weekly Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Fluoxetine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Fluoxetine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Fluoxetine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fluoxetine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluoxetine.
Prozac Weekly Toxicity & Overdose RiskMost instances of fluoxetine overdose tend to be minor and short-term, with common symptoms including drowsiness, trembling, rapid heartbeat, nausea, and vomiting. Immediate medical care is usually enough to manage these symptoms. In rare cases, a fluoxetine overdose may lead to seizures, symptoms of serotonin syndrome, and muscle breakdown. These cases often involve the ingestion of large amounts of fluoxetine in combination with other drugs or substances.
Prozac Weekly Novel Uses: Which Conditions Have a Clinical Trial Featuring Prozac Weekly?
A total of 881 active studies are currently assessing the capability of Prozac Weekly to combat Disease, Anorexia Nervosa and facilitate maintenance therapy.Condition
Clinical Trials
Trial Phases
maintenance therapy
0 Actively Recruiting
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Bulimia Nervosa
15 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Premature Ejaculation
0 Actively Recruiting
Unipolar Depression
51 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 2, Phase 3, Phase 1
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
moderate to severe symptoms
0 Actively Recruiting
Bipolar Disorder
1 Actively Recruiting
Phase 4
Anorexia Nervosa
0 Actively Recruiting
Panic Disorder (With or Without Agoraphobia)
0 Actively Recruiting
Depression
698 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Myoclonus
2 Actively Recruiting
Phase 2, Not Applicable
Cataplexy
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Prozac Weekly Reviews: What are patients saying about Prozac Weekly?
5Patient Review
6/15/2014 I really think this medication should be more accessible, maybe in water form. It's helped me a lot over the years and I'm grateful for it.
5Patient Review
10/15/2009 I'm really pleased with the results of this treatment, but I am concerned that it might have raised my LDL cholesterol levels.
5Patient Review
10/3/2013 I've just started taking this medication and I'm already seeing benefits. No negative interactions with my Tramadol, either, so that's great news.
5Patient Review
12/17/2009 Prozac was a godsend that allowed me to process my trauma without being overwhelmed by emotion. I discontinued use when I felt stronger, and it really helped me get through a tough time.
5Patient Review
2/8/20094.3Patient Review
4/14/2009 This medication has improved my life overall, though I have put on some weight since starting it.
4Patient Review
3/29/2009 The treatment was effective until other medications were added to the mix.
3.7Patient Review
12/20/20083.7Patient Review
1/15/20093.7Patient Review
1/17/20093Patient Review
4/7/2009 While I can't say I'm thrilled with this medicine, it's better than the alternative of not taking it. I tried going without it and ended up screaming mad. The headaches could be from the Fluoxtine or something else, but they're a constant issue.
3Patient Review
2/10/20092.7Patient Review
6/7/2009 I lost my husband because I had no sex drive.
2.3Patient Review
5/5/2009 At first, this medication really helped me. But then it stopped working as well as it should, so my doctor increased the dosage. Now, after five months of taking it, I feel like it's not working at all anymore. My symptoms have gotten worse – I can't eat or sleep, and I've lost 50lbs in just a month and a half. What's going on?
2.3Patient Review
3/3/2009 I've been feeling better about myself lately, and I think it has to do with less stress. I haven't been taking my medication as much, but I have noticed a difference when I do take them.
1.7Patient Review
2/20/2009 I am concerned about the long-term effects of Prozac, and my husband has been taking it for over a year. He wants to stop taking it, but I don't know if that is a good idea. Are there any side effects to stopping the medication suddenly?
Patient Q&A Section about prozac weekly
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can I take Prozac once a week?
"On Tuesday, the FDA approved a weekly version of the Prozac medication for the long-term treatment of depression. This makes Prozac the only prescription antidepressant with once-a-week dosing."
Answered by AI
How do I start Prozac Weekly?
"Begin taking this medication seven days after your last dose of fluoxetine, which is taken daily. The dosage is dependent on your medical condition and response to treatment. It is important to take this medication regularly in order to experience the maximum benefit. To help you remember, take it on the same day each week."
Answered by AI
How does Prozac Weekly work?
"Prozac Weekly is a drug that belongs to a group of drugs called selective serotonin reuptake inhibitor (SSRI). These types of drugs work by changing the levels of certain chemicals in the brain that affect a person's mood. Prozac Weekly is available as an extended release capsule and is typically taken once a week with or without food."
Answered by AI
What is the difference between Prozac and Prozac Weekly?
"Fluoxetine 90 mg given once a week may be an option for people who have responded to fluoxetine given every day, and who want to switch to a maintenance dose. The weekly dose may not be as effective as the daily dose in preventing relapse."
Answered by AI