Prograf

Vitiligo, Pyoderma Gangrenosum, Kidney Transplantation + 12 more
Treatment
5 FDA approvals
20 Active Studies for Prograf

What is Prograf

TacrolimusThe Generic name of this drug
Treatment SummaryTacrolimus (also known as FK-506 or Fujimycin) is a medicine used to prevent organ rejection after transplantation. It is also used to treat severe cases of atopic dermatitis, uveitis, and vitiligo. The drug was first discovered in 1984 from a soil sample in Japan. Tacrolimus is a macrolide that works by binding to a protein called FKBP-12, which then inhibits the activity of the immune system and reduces the risk of organ rejection.
Prografis the brand name
image of different drug pills on a surface
Prograf Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prograf
Tacrolimus
1994
138

Approved as Treatment by the FDA

Tacrolimus, also called Prograf, is approved by the FDA for 5 uses such as Kidney Transplant Rejection and Liver Transplant Rejection .
Kidney Transplant Rejection
Liver Transplant Rejection
Kidney Transplantation
Immunosuppressive Treatment
Kidney

Effectiveness

How Prograf Affects PatientsTacrolimus works by blocking a certain enzyme, stopping certain signals from being sent to the T-lymphocytes, and reducing the amount of a certain protein. Compared to cyclosporine, tacrolimus is more effective in reducing organ rejection. It can also be used to treat eczema, though it is not as strong as steroids. An advantage of tacrolimus is that it can be used on the face, while steroids cannot. For other parts of the body, steroids are usually the better treatment.
How Prograf works in the bodyWe don't know exactly how tacrolimus works to treat atopic dermatitis, but we have seen a few things. It appears to limit T-lymphocyte activation by binding to a protein called FKBP-12. This stops a process called dephosphorylation from happening, which is necessary for the formation of lymphokines. Tacrolimus also seems to reduce the production of several proteins that are involved in T-cell activation, as well as block the release of substances from mast cells and basophils. Finally, it may down-regulate the expression of FceRI on Langerh

When to interrupt dosage

The measure of Prograf is subject to the diagnosed condition, including Vitiligo, Rejection; Transplant, Kidney and Pyoderma Gangrenosum. The quantity of dosage deviates, depending on the procedure of delivery (e.g. Capsule, gelatin coated - Oral or Topical) indicated in the table below.
Condition
Dosage
Administration
Immunocompromised
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Dermatitis, Atopic
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Liver
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Dermatitis, Atopic
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Rheumatoid Arthritis
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Lichen Planus, Oral
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Chronic Graft Versus Host Disease
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Lung
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Psoriasis
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Pyoderma Gangrenosum
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Vitiligo
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Kidney Transplantation
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Prophylaxis against heart transplant rejection
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Kidney
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical
Immunosuppressive Treatment
0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment - Topical, Ointment, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Intravenous, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Granule, Granule - Oral, Cutaneous, Ointment - Cutaneous, Injection, solution, Injection, solution - Intravenous, Granule, for suspension, Granule, for suspension - Oral, Kit, Cream, Cream - Topical, Solution - Topical

Warnings

Prograf has one contraindication, meaning that it should not be employed while encountering the conditions listed in the following table.Prograf Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tacrolimus may interact with Pulse Frequency
There are 20 known major drug interactions with Prograf.
Common Prograf Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Tacrolimus.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Tacrolimus.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Tacrolimus.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Tacrolimus.
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Tacrolimus.
Prograf Toxicity & Overdose RiskTaking too much of this drug can lead to blurred vision, kidney and liver damage, seizures, trembling, high blood pressure, low levels of magnesium, diabetes, high levels of potassium, itching, difficulty sleeping, and confusion. The lowest toxic dose in rats is 134-194mg/kg.
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Prograf Novel Uses: Which Conditions Have a Clinical Trial Featuring Prograf?

147 active research studies are currently being conducted to assess the potential of Prograf to alleviate Oral Lichen Planus, Pyoderma Gangrenosum and refractory Rheumatoid Arthritis.
Condition
Clinical Trials
Trial Phases
Pyoderma Gangrenosum
8 Actively Recruiting
Phase 2, Phase 4, Early Phase 1, Phase 3, Not Applicable
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Immunocompromised
5 Actively Recruiting
Phase 3, Not Applicable, Phase 1
Lichen Planus, Oral
0 Actively Recruiting
Vitiligo
7 Actively Recruiting
Phase 2, Phase 3, Phase 1
Kidney Transplantation
0 Actively Recruiting
Kidney
0 Actively Recruiting
Immunosuppressive Treatment
0 Actively Recruiting
Liver
0 Actively Recruiting
Lung
0 Actively Recruiting
Dermatitis, Atopic
0 Actively Recruiting
Prophylaxis against heart transplant rejection
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Chronic Graft Versus Host Disease
26 Actively Recruiting
Phase 4, Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1
Dermatitis, Atopic
0 Actively Recruiting

Prograf Reviews: What are patients saying about Prograf?

5Patient Review
5/21/2014
Prograf for Prevention of Liver Transplant Rejection
I had a kidney transplant about a year ago and have been taking Prograf since. My creatinine levels have always stayed stable between 1.3 and 1.4. But, for the last three months I've been taking Tracolimus (the generic version) and my creatinine has risen from 1.5 to 1.7. Has anyone else experienced this? Or does anyone know if this could be the problem?
5Patient Review
8/16/2015
Prograf for Prevention of Liver Transplant Rejection
So far, I'm five weeks in and feeling good. There was a little bit of initial adjustments needed for the first hour or two, but since then it's been fine. No rejections thus far, touch wood.
5Patient Review
2/13/2015
Prograf for Rejection of Liver Transplant
Though I experienced a range of side effects, like hair loss, tingling, blurred vision and insomnia, I'm thankful that this treatment didn't negatively impact my liver.
4.7Patient Review
8/2/2015
Prograf for Prevention of Cardiac Transplant Rejection
It's only been three months since my liver transplant, and I was already on dialysis. However, after just six weeks I had a fever of 100.3. They found an infection in my blood.
4.7Patient Review
1/29/2017
Prograf for Prevention of Liver Transplant Rejection
Prograf has been a life-saver for me. I had a liver transplant when I was two and a half, and have been on Prograf ever since. It's tough on my kidneys, which causes me to have high blood pressure, but I'm also taking another medication to help with that. This New Year's Eve will be my 12th "liver-versary", and I credit Prograf (along with a few other drugs) for keeping me alive all this time.
View All Reviews
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Patient Q&A Section about prograf

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Prograf used to treat?

"Tacrolimus is a drug that suppresses the immune system and is used to prevent organ rejection in children who have had liver transplants."

Answered by AI

Is Prograf an immunosuppressant?

"Today's decision represents the first time an immunosuppressant drug has been approved to prevent rejection in adult and pediatric patients who receive lung transplants. Prograf is the only drug product of its kind that has been approved for this population."

Answered by AI

What are the side effects for Prograf?

"The most common adverse reactions (occurring in more than 40% of PROGRAF-treated liver transplant patients) include: tremor, headache, diarrhea, hypertension, nausea, abnormal renal function, abdominal pain, insomnia, paresthesia, anemia, pain, fever, asthenia, hyperkalemia, hypomagnesemia, and hyperglycemia."

Answered by AI

Is Prograf a steroid?

"Tacrolimus (Prograf) does not belong to the class of drugs called steroids or corticosteroids. Sometimes, corticosteroids and calcineurin inhibitors are used together to prevent transplant rejections."

Answered by AI

Clinical Trials for Prograf

Have you considered Prograf clinical trials? We made a collection of clinical trials featuring Prograf, we think they might fit your search criteria.
Have you considered Prograf clinical trials? We made a collection of clinical trials featuring Prograf, we think they might fit your search criteria.
Have you considered Prograf clinical trials? We made a collection of clinical trials featuring Prograf, we think they might fit your search criteria.
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