Persantine

cardiac valve replacement, Ischemic Attack, Transient, Coronary Disease + 9 more
Treatment
6 FDA approvals
13 Active Studies for Persantine

What is Persantine

DipyridamoleThe Generic name of this drug
Treatment SummaryDipyridamole is a drug that works by inhibiting an enzyme called phosphodiesterase. This prevents the absorption and breakdown of a molecule called adenosine, which helps to reduce blood clotting and improve the production of a hormone-like substance called prostacyclin.
Dipyridamoleis the brand name
Persantine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dipyridamole
Dipyridamole
1980
98

Approved as Treatment by the FDA

Dipyridamole, also known as Dipyridamole, is approved by the FDA for 6 uses like Postoperative Thromboembolism and cardiac valve replacement .
Postoperative Thromboembolism
cardiac valve replacement
Venous Thrombosis
Stroke
Used to treat Cerebrovascular Accident in combination with Acetylsalicylic acid
Stroke
Used to treat previous stroke in combination with Acetylsalicylic acid
Transient Ischemic Attack (TIA)
Used to treat Transient Ischemic Attack in combination with Acetylsalicylic acid

Effectiveness

How Persantine Affects PatientsDipyridamole is a drug used to open up blood vessels and stop blood clots from forming. It is often taken in combination with other medicines, such as warfarin, to help prevent stroke in people with heart or vascular problems. Dipyridamole is also used to take pictures of the heart's blood flow, to prevent blood clots from forming, and in combination with aspirin to help avoid stroke.
How Persantine works in the bodyDipyridamole works to stop blood clotting by preventing the breakdown of molecules that inhibit platelet function. It also increases the production of a molecule called prostacyclin, which stops platelets from clumping together and forming a clot.

When to interrupt dosage

The suggested measure of Persantine is dependent upon the diagnosed affliction, such as Thrombosis, preceding stroke, and Stroke. The amount of dosage fluctuates, in line with the administration approach (e.g. Tablet, coated or Capsule) presented in the table below.
Condition
Dosage
Administration
cardiac valve replacement
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Ischemic Attack, Transient
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Coronary Disease
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Stroke
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Heart Valve Prosthesis
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Myocardial Perfusion Imaging
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Venous Thrombosis
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Anti-platelet Therapy
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Ischemic Stroke
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Stroke
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diagnostic Imaging
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Transient Ischemic Attack (TIA)
, 25.0 mg, 50.0 mg, 200.0 mg, 75.0 mg, 5.0 mg/mL, 100.0 mg, 150.0 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Injection, Injection - Intravenous, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral

Warnings

Persantine has three contraindications and should not be amalgamated with any of the conditions listed in the table below.Persantine Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Atrioventricular Block
Do Not Combine
Respiratory Sounds
Do Not Combine
There are 20 known major drug interactions with Persantine.
Common Persantine Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Dipyridamole is combined with Abrocitinib.
Acebutolol
Major
Dipyridamole may increase the bradycardic activities of Acebutolol.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Dipyridamole.
Alprenolol
Major
Dipyridamole may increase the bradycardic activities of Alprenolol.
Alprostadil
Major
The risk or severity of hypotension and priapism can be increased when Dipyridamole is combined with Alprostadil.
Persantine Toxicity & Overdose RiskLow blood pressure can be a short-term side effect of this drug, but medication to raise blood pressure can be used if needed. Toxic levels of this drug in rats are higher than 6,000 mg/kg, while in dogs it is approximately 400 mg/kg. The lethal dose for rats is 8.4 g/kg when taken orally.

Persantine Novel Uses: Which Conditions Have a Clinical Trial Featuring Persantine?

38 active clinical trials are presently exploring the potential of Persantine to reduce Postoperative Thromboembolism, Stroke and Thrombosis.
Condition
Clinical Trials
Trial Phases
Coronary Disease
1 Actively Recruiting
Not Applicable
Venous Thrombosis
0 Actively Recruiting
cardiac valve replacement
0 Actively Recruiting
Heart Valve Prosthesis
0 Actively Recruiting
Transient Ischemic Attack (TIA)
2 Actively Recruiting
Phase 4, Not Applicable
Diagnostic Imaging
0 Actively Recruiting
Ischemic Stroke
0 Actively Recruiting
Ischemic Attack, Transient
0 Actively Recruiting
Anti-platelet Therapy
0 Actively Recruiting
Stroke
0 Actively Recruiting
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Myocardial Perfusion Imaging
1 Actively Recruiting
Phase 1

Persantine Reviews: What are patients saying about Persantine?

5Patient Review
6/28/2010
Persantine for Transient Ischemic Attack
It's been 16 months since I had a TIA, so this treatment is definitely working. The only downside is that I experience quite a bit of muscle pain/cramping in my legs; however, that is a small price to pay for avoiding another attack.
5Patient Review
8/8/2009
Persantine for Myocardial Reinfarction Prevention
This was prescribed following a stroke and I had a blood clot located in a crucial spot in the brain. I cannot tolerate Coumadin and this drug works wonders for me!
5Patient Review
9/25/2008
Persantine for Transient Ischemic Attack
I've been making great progress with my treatment thanks to this medication.
5Patient Review
10/3/2012
Persantine for Prevention for a Blood Clot going to the Brain
No issues with the product itself, though I did find the container difficult to open.
3Patient Review
4/26/2014
Persantine for Transient Ischemic Attack
I'm not sure if this is the cause, but I've developed some pretty severe arthritis and weakness in my calf muscles since taking this medication. It's gotten to the point where I can't stand or walk.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about persantine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Persantine?

"Common side effects of the medication include dizziness, stomach upset, diarrhea, vomiting, headache, and flushing. These side effects are usually mild and resolve over time as your body adjusts to the medication."

Answered by AI

Is Persantine still available?

"Boehringer Ingelheim Pharmaceuticals has announced the permanent discontinuation of Persantine (dipyridamole) tablets. The decision to discontinue the product is business-related and not due to product safety or efficacy."

Answered by AI

What is a Persantine injection?

"Dipyridamole is used to prevent blood clots after heart valve replacement surgery. It is also given as part of a test that shows how well your heart is pumping blood."

Answered by AI

What is the drug Persantine used for?

"It helps prevent blood clots by keeping platelets from sticking together.

Dipyridamole is a medication used to prevent the formation of blood clots. It is often used in combination with other medications, such as warfarin, to keep clots from forming after heart valve replacements. Clots are a serious complication that can cause strokes, heart attacks, or blocked blood vessels in the lungs (pulmonary embolisms). Dipyridamole works by keeping platelets from sticking together."

Answered by AI

Clinical Trials for Persantine

Have you considered Persantine clinical trials? We made a collection of clinical trials featuring Persantine, we think they might fit your search criteria.
Have you considered Persantine clinical trials? We made a collection of clinical trials featuring Persantine, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top