Oxaliplatin

Colonic Neoplasms, Colorectal Carcinoma, Colorectal Neoplasms

Treatment

6 FDA approvals

1 Active Study for Oxaliplatin

Treatment for

Colonic Neoplasms

What is Oxaliplatin

Oxaliplatin

The Generic name of this drug

Treatment Summary

Oxaliplatin is a chemotherapy drug used to treat certain types of cancer, most commonly colorectal cancer. It is usually given in combination with two other drugs, fluorouracil and leucovorin, which are known as Folfox. Oxaliplatin is a form of platinum-based chemotherapy, similar to cisplatin and carboplatin, but it has been improved with cyclohexyldiamine to increase its effectiveness against tumors. The oxalato bidentate derived from oxalic acid is used to improve its water solubility. Oxaliplatin is sold under the

Eloxatin

is the brand name

image of different drug pills on a surface

Oxaliplatin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Eloxatin

Oxaliplatin

2002

Approved as Treatment by the FDA

Oxaliplatin, otherwise called Eloxatin, is approved by the FDA for 6 uses including Colorectal Carcinoma and Colorectal Neoplasms .

Colorectal Carcinoma

Used to treat Advanced Colorectal Cancer in combination with Fluorouracil

Colorectal Neoplasms

Used to treat Surgical Resection of the Colorectal Tumor in combination with Fluorouracil

Advanced Colorectal Cancer

Used to treat Advanced Colorectal Cancer in combination with Fluorouracil

Stage III Colon Cancer

Used to treat Stage III Colon Cancer in combination with Fluorouracil

Surgical Resection of the Colorectal Tumor

Used to treat Surgical Resection of the Colorectal Tumor in combination with Fluorouracil

Colonic Neoplasms

Used to treat Stage III Colon Cancer in combination with Fluorouracil

Effectiveness

How Oxaliplatin Affects Patients

Oxaliplatin stops the cells in your body from making DNA. It also stops them from making the proteins and RNA they need to function. The more of the drug that is taken, the more it affects the cells in your body.

How Oxaliplatin works in the body

Oxaliplatin works by stopping DNA from being made and copied. It does this by changing the chemical structure of the drug and then binding itself to the guanine and cytosine molecules in the DNA. This cross-linking of the DNA makes it impossible for it to be copied and prevents further cell growth. This process is not related to any specific stage in the cell cycle, and so it affects all cells equally.

When to interrupt dosage

The prescribed dosage of Oxaliplatin is contingent upon the diagnosed malady, including Stage III Colon Cancer, Colorectal Carcinoma and Colorectal Neoplasms. The measure of dosage shifts, depending on the technique of delivery as outlined in the table below.

Condition

Dosage

Administration

Colorectal Carcinoma

5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL

, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Powder, for solution - Intravenous, Powder, for solution, Injection, solution - Intravenous, Injection, solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Solution, concentrate - Intravenous, Solution, concentrate

Colonic Neoplasms

5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL

Colorectal Neoplasms

5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL

Warnings

Oxaliplatin Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Oxaliplatin.

Common Oxaliplatin Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Oxaliplatin is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Oxaliplatin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Abatacept.

Abetimus

Major

The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Acteoside.

Oxaliplatin Toxicity & Overdose Risk

There have been a few reported cases of oxaliplatin overdose. One patient received two doses within 24 hours (total of 260mg/m<sup>2</sup>) and suffered from low platelet count (below 25,000/mm<sup>3</sup>) without any bleeding. In two other cases, patients were given oxaliplatin instead of carboplatin, one received 500mg and the other received 650mg. Symptoms included difficulty breathing, wheezing, tingling or numbness, vomiting, and chest pain. The patient given 500mg went into respiratory failure and severe bradycardia,

image of a doctor in a lab doing drug, clinical research

Oxaliplatin Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxaliplatin?

Five active trials are evaluating the potential of Oxaliplatin to combat Colorectal Neoplasms, Stage III Colon Cancer and Colorectal Carcinoma.

Condition

Clinical Trials

Trial Phases

Colonic Neoplasms

1 Actively Recruiting

Not Applicable

Colorectal Neoplasms

0 Actively Recruiting

Colorectal Carcinoma

0 Actively Recruiting

Oxaliplatin Reviews: What are patients saying about Oxaliplatin?

Patient Review

1/2/2014

Oxaliplatin for Colon and Rectal Cancer that has Spread to Another Area

The numbness in my extremities is the only downside to this treatment, but it's worth it for the pain relief.

4.7

Patient Review

1/24/2013

Oxaliplatin for Lymph Node Positive Colon Cancer

I was given this treatment for too long and now I'm experiencing intense pain in my fingers and feet. It's affecting my ability to do very basic tasks. Not sure if the benefits outweigh the drawbacks at this point.

4.7

Patient Review

5/11/2013

Oxaliplatin for Colon and Rectal Cancer that has Spread to Another Area

Overall, I'm pleased with how this drug performed as part of a FOLFOX cocktail for my Stage IIIb Colon Cancer. The only downside is the peripheral neuropathy it caused. Not being able to feel your fingers, toes, and soles of your feet is not fun. It has been 6 months since my last treatment. We'll see what happens next.

Patient Review

10/12/2009

Oxaliplatin for Lymph Node Positive Colon Cancer

Patient Review

5/25/2012

Oxaliplatin for Colon and Rectal Cancer that has Spread to Another Area

The oxaliplatin was successful in holding the cancer at bay; however, it did cause some ocular problems.

3.7

Patient Review

8/1/2011

Oxaliplatin for Colon and Rectal Cancer that has Spread to Another Area

My husband has developed neuropathy as a result of this drug. He says that if he had known about the severity of the side effects, he would not have used it. However, if the drug did save his life, then it was worth it. He is in constant pain, and feels like he has no quality of life.

3.7

Patient Review

1/28/2019

Oxaliplatin for Lymph Node Positive Colon Cancer

I had twelve rounds of chemo, ten with Oakiplaitin. The cold sensitivity was bad, as was the neuropathy in my hands and feet. I finished chemo in September 2018, and the cold sensitivity is gone, and the neuropathy is getting better. Hang in there!!!

3.7

Patient Review

7/8/2010

Oxaliplatin for Cancer of Large Intestine

The short-term side effects while on the medication were not pleasant. However, I am now dealing with neuropathy as a long term effect, and it is significantly worse.

3.3

Patient Review

6/27/2011

Oxaliplatin for Cancer of Large Intestine

I experienced a lot of negative side effects from this treatment, the worst being neuropathy and nausea. These symptoms lingered for days after the actual treatment, and in some cases (like with the neuropathy) actually got worse over time.

3.3

Patient Review

10/31/2009

Oxaliplatin for Cancer of Large Intestine

I am experiencing peripheral neuropathy, which is very difficult for me.

Patient Review

12/3/2015

Oxaliplatin for Lymph Node Positive Colon Cancer

I haven't had any serious issues while taking this medication. My fingers and toes tingle a bit when they get cold, but it goes away pretty quickly. If the tingling is bad, I rinse them in warm/hot water and it goes away.

2.7

Patient Review

6/21/2011

Oxaliplatin for Lymph Node Positive Colon Cancer

So far, I've had neuropathy in my hands and feet, nausea and vomiting, and can't stand anything cooler than room temperature. My hands are also constantly drawing and cramping. It's easily been one of the worst experiences of my life.

2.3

Patient Review

3/22/2009

Oxaliplatin for Cancer of Large Intestine

Patient Review

11/26/2016

Oxaliplatin for Lymph Node Positive Colon Cancer

While this drug has shown to be effective in treating colon cancer, it's very harsh on the body. I often feel nauseous and have neuropathy in my hands and mouth after treatment. This makes it difficult to eat or drink anything.

Patient Review

7/11/2009

Oxaliplatin for Colon and Rectal Cancer that has Spread to Another Area

1.7

Patient Review

5/27/2010

Oxaliplatin for Cancer of Large Intestine

The oncologist and I decided that, due to the early stage of my colon cancer, we would take an aggressive approach with this treatment. The only side effects have been extreme fatigue and moderate nausea. The cancer is now in remission after 6 weeks and we will review again in another 2 weeks. So far, I'm very pleased with the results.

1.7

Patient Review

2/28/2010

Oxaliplatin for Lymph Node Positive Colon Cancer

I'm not entirely sure which drug is giving me trouble, but I'll update this review once I finish my treatment.

1.7

Patient Review

3/2/2011

Oxaliplatin for Lymph Node Positive Colon Cancer

I developed peripheral neuropathy from this medication, which led to me losing feeling in my feet. Now, the issue has progressed to my fingers. I'm hoping the doctor can give me some relief today.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oxaliplatin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How effective is oxaliplatin?

"The study found that the introduction of oxaliplatin had no significant effect on the three-year disease-free survival rate or the five-year overall survival rate."

Answered by AI

What are side effects of oxaliplatin?

"If you experience any of the following symptoms, contact your doctor:

Diarrhea, changes in taste, mouth sores, nosebleeds, tiredness, headache, dizziness, difficulty sleeping, nausea, or vomiting. Medication may be prescribed to prevent or relieve nausea and vomiting."

Answered by AI

Does oxaliplatin cause hair loss?

"During cancer treatment, it is common to lose some or all hair on your head, as well as facial and body hair. This typically occurs 3-4 weeks after treatment begins. To prepare for this, many people choose to buy a wig before hair loss begins. Hair loss is not permanent, and hair typically begins to grow back during treatment."

Answered by AI

Is oxaliplatin a strong chemo?

"Oxaliplatin is known to be the most toxic chemotherapy when it comes to nerve damage, and is the root cause of many peripheral neuropathies. These neuropathies can be a serious problem for cancer patients as there is no effective prevention strategy and the only known treatment, duloxetine, only seems to help improve symptoms."

Answered by AI