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What is Oxaliplatin
OxaliplatinThe Generic name of this drug
Treatment SummaryOxaliplatin is a chemotherapy drug used to treat certain types of cancer, most commonly colorectal cancer. It is usually given in combination with two other drugs, fluorouracil and leucovorin, which are known as Folfox. Oxaliplatin is a form of platinum-based chemotherapy, similar to cisplatin and carboplatin, but it has been improved with cyclohexyldiamine to increase its effectiveness against tumors. The oxalato bidentate derived from oxalic acid is used to improve its water solubility. Oxaliplatin is sold under the
Eloxatinis the brand name
Oxaliplatin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Eloxatin
Oxaliplatin
2002
91
Approved as Treatment by the FDA
Oxaliplatin, otherwise called Eloxatin, is approved by the FDA for 3 uses including Colorectal Carcinoma and Colorectal Neoplasms .Colorectal Carcinoma
Used to treat Advanced Colorectal Cancer in combination with Fluorouracil
Colorectal Neoplasms
Used to treat Surgical Resection of the Colorectal Tumor in combination with Fluorouracil
Stage III Colon Cancer
Used to treat Stage III Colon Cancer in combination with Fluorouracil
Effectiveness
How Oxaliplatin Affects PatientsOxaliplatin stops the cells in your body from making DNA. It also stops them from making the proteins and RNA they need to function. The more of the drug that is taken, the more it affects the cells in your body.
How Oxaliplatin works in the bodyOxaliplatin works by stopping DNA from being made and copied. It does this by changing the chemical structure of the drug and then binding itself to the guanine and cytosine molecules in the DNA. This cross-linking of the DNA makes it impossible for it to be copied and prevents further cell growth. This process is not related to any specific stage in the cell cycle, and so it affects all cells equally.
When to interrupt dosage
The prescribed dosage of Oxaliplatin is contingent upon the diagnosed malady, including Stage III Colon Cancer, Colorectal Carcinoma and Colorectal Neoplasms. The measure of dosage shifts, depending on the technique of delivery as outlined in the table below.Condition
Dosage
Administration
Colorectal Neoplasms
5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Stage III Colon Cancer
5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Colorectal Carcinoma
5.0 mg/mL, , 10.0 mg/mL, 50.0 mg, 100.0 mg, 20.0 mg/mL, 50.0 mg/mL, 100.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Warnings
Oxaliplatin ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Oxaliplatin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Oxaliplatin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Oxaliplatin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Acteoside.
Oxaliplatin Toxicity & Overdose RiskThere have been a few reported cases of oxaliplatin overdose. One patient received two doses within 24 hours (total of 260mg/m<sup>2</sup>) and suffered from low platelet count (below 25,000/mm<sup>3</sup>) without any bleeding. In two other cases, patients were given oxaliplatin instead of carboplatin, one received 500mg and the other received 650mg. Symptoms included difficulty breathing, wheezing, tingling or numbness, vomiting, and chest pain. The patient given 500mg went into respiratory failure and severe bradycardia,
Oxaliplatin Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxaliplatin?
Five active trials are evaluating the potential of Oxaliplatin to combat Colorectal Neoplasms, Stage III Colon Cancer and Colorectal Carcinoma.Condition
Clinical Trials
Trial Phases
Colorectal Carcinoma
3 Actively Recruiting
Phase 2, Phase 3
Colorectal Neoplasms
0 Actively Recruiting
Stage III Colon Cancer
4 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Oxaliplatin Reviews: What are patients saying about Oxaliplatin?
5Patient Review
1/2/2014 The numbness in my extremities is the only downside to this treatment, but it's worth it for the pain relief.
4.7Patient Review
1/24/2013 I was given this treatment for too long and now I'm experiencing intense pain in my fingers and feet. It's affecting my ability to do very basic tasks. Not sure if the benefits outweigh the drawbacks at this point.
4.7Patient Review
5/11/2013 Overall, I'm pleased with how this drug performed as part of a FOLFOX cocktail for my Stage IIIb Colon Cancer. The only downside is the peripheral neuropathy it caused. Not being able to feel your fingers, toes, and soles of your feet is not fun. It has been 6 months since my last treatment. We'll see what happens next.
4Patient Review
10/12/20094Patient Review
5/25/2012 The oxaliplatin was successful in holding the cancer at bay; however, it did cause some ocular problems.
3.7Patient Review
8/1/2011 My husband has developed neuropathy as a result of this drug. He says that if he had known about the severity of the side effects, he would not have used it. However, if the drug did save his life, then it was worth it. He is in constant pain, and feels like he has no quality of life.
3.7Patient Review
1/28/2019 I had twelve rounds of chemo, ten with Oakiplaitin. The cold sensitivity was bad, as was the neuropathy in my hands and feet. I finished chemo in September 2018, and the cold sensitivity is gone, and the neuropathy is getting better. Hang in there!!!
3.7Patient Review
7/8/2010 The short-term side effects while on the medication were not pleasant. However, I am now dealing with neuropathy as a long term effect, and it is significantly worse.
3.3Patient Review
6/27/2011 I experienced a lot of negative side effects from this treatment, the worst being neuropathy and nausea. These symptoms lingered for days after the actual treatment, and in some cases (like with the neuropathy) actually got worse over time.
3.3Patient Review
10/31/2009 I am experiencing peripheral neuropathy, which is very difficult for me.
3Patient Review
12/3/2015 I haven't had any serious issues while taking this medication. My fingers and toes tingle a bit when they get cold, but it goes away pretty quickly. If the tingling is bad, I rinse them in warm/hot water and it goes away.
2.7Patient Review
6/21/2011 So far, I've had neuropathy in my hands and feet, nausea and vomiting, and can't stand anything cooler than room temperature. My hands are also constantly drawing and cramping. It's easily been one of the worst experiences of my life.
2.3Patient Review
3/22/20092Patient Review
11/26/2016 While this drug has shown to be effective in treating colon cancer, it's very harsh on the body. I often feel nauseous and have neuropathy in my hands and mouth after treatment. This makes it difficult to eat or drink anything.
2Patient Review
7/11/20091.7Patient Review
5/27/2010 The oncologist and I decided that, due to the early stage of my colon cancer, we would take an aggressive approach with this treatment. The only side effects have been extreme fatigue and moderate nausea. The cancer is now in remission after 6 weeks and we will review again in another 2 weeks. So far, I'm very pleased with the results.
1.7Patient Review
2/28/2010 I'm not entirely sure which drug is giving me trouble, but I'll update this review once I finish my treatment.
1.7Patient Review
3/2/2011 I developed peripheral neuropathy from this medication, which led to me losing feeling in my feet. Now, the issue has progressed to my fingers. I'm hoping the doctor can give me some relief today.
Patient Q&A Section about oxaliplatin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is oxaliplatin?
"The study found that the introduction of oxaliplatin had no significant effect on the three-year disease-free survival rate or the five-year overall survival rate."
Answered by AI
What are side effects of oxaliplatin?
"If you experience any of the following symptoms, contact your doctor:
Diarrhea, changes in taste, mouth sores, nosebleeds, tiredness, headache, dizziness, difficulty sleeping, nausea, or vomiting. Medication may be prescribed to prevent or relieve nausea and vomiting."
Answered by AI
Does oxaliplatin cause hair loss?
"During cancer treatment, it is common to lose some or all hair on your head, as well as facial and body hair. This typically occurs 3-4 weeks after treatment begins. To prepare for this, many people choose to buy a wig before hair loss begins. Hair loss is not permanent, and hair typically begins to grow back during treatment."
Answered by AI
Is oxaliplatin a strong chemo?
"Oxaliplatin is known to be the most toxic chemotherapy when it comes to nerve damage, and is the root cause of many peripheral neuropathies. These neuropathies can be a serious problem for cancer patients as there is no effective prevention strategy and the only known treatment, duloxetine, only seems to help improve symptoms."
Answered by AI