What is Oseni
PioglitazoneThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes mellitus. It is taken in addition to diet, exercise, and other diabetes medications and works by increasing the body’s sensitivity to insulin. This helps the body better absorb glucose and control blood sugar levels. Although Pioglitazone is effective, it has been linked to multiple side effects and warnings, such as congestive heart failure and bladder cancer, and is not as widely used as other alternatives.
Actosis the brand name
Oseni Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actos
Pioglitazone
1999
252
Effectiveness
How Oseni Affects PatientsPioglitazone helps the body respond better to insulin, making it easier for the body to process glucose. This helps to lower blood glucose levels, insulin levels, and the amount of HbA1c in the body. However, taking pioglitazone can lead to fluid retention, which can worsen congestive heart failure, so it should not be used in patients with heart failure or are at risk of developing it. Additionally, there is evidence that pioglitazone may increase the risk of bladder cancer, so it should not be used in patients with active bladder cancer and should be used with caution in those with
How Oseni works in the bodyPioglitazone helps the body to respond better to insulin, the hormone that controls blood sugar levels. It does this by activating a certain protein in tissues that respond to insulin, like fat, muscle and liver cells. This protein helps to increase the actions of insulin so that it can better control glucose production and use. As a result, pioglitazone can reduce insulin resistance, a condition associated with type 2 diabetes, without causing your body to make more insulin.
When to interrupt dosage
The endorsed measure of Oseni is contingent upon the diagnosed condition, such as Diet, Physical Activity and Type 2 Diabetes. The amount of dosage likewise differs, as per the administration methodology (e.g. Tablet, film coated or Tablet, film coated - Oral) outlined in the table beneath.Condition
Dosage
Administration
Diabetic Neuropathy
15.0 mg, 30.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diet
15.0 mg, 30.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Physical Activity
15.0 mg, 30.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
15.0 mg, 30.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
15.0 mg, 30.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Warnings
Oseni has seven contraindications, thus it should not be consumed when exposed to any of the conditions in the following table.Oseni ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Urinary Bladder
Do Not Combine
Urinary Bladder
Do Not Combine
uninvestigated macroscopic hematuria
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pioglitazone may interact with Toxoplasma Infections
Common Oseni Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Pioglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Pioglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Pioglitazone.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Pioglitazone.
Oseni Toxicity & Overdose RiskThe lowest toxic dose of pioglitazone in mice is 24mg/kg for 4 days, and in rats is 3mg/kg for 6 days. In one reported case of overdosing, a patient took up to 180mg daily for 7 days without any adverse symptoms. If someone overdoses on pioglitazone, medical attention should be sought and the patient's symptoms should be monitored.
Oseni Novel Uses: Which Conditions Have a Clinical Trial Featuring Oseni?
Presently, 300 active studies are being conducted to ascertain the potential of Oseni to manage Type 2 Diabetes, Type 2 Diabetes-related Physical Activity and other conditions.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
93 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2, Phase 1
Type 2 Diabetes
175 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Physical Activity
34 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Diet
3 Actively Recruiting
Not Applicable
Diabetic Neuropathy
17 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Early Phase 1
Oseni Reviews: What are patients saying about Oseni?
5Patient Review
1/24/2015 I've been trying to get my blood sugar levels under control for years now, and this is the first medication that's actually helped me. I was able to reduce my insulin intake by half within the month of taking this drug, and have seen significant improvements in my quality of life as a result. The only downside is that it's quite expensive.
5Patient Review
10/20/2014 Oseni has helped me a lot by reducing my A1C and fasting sugar levels.
5Patient Review
6/29/2014 My fasting blood glucose dropped significantly within a month of starting this medication, and I didn't have to change my diet or exercise routine at all.
4.7Patient Review
10/14/2014 Oseni has been great for my A1C numbers. I recently saw results of 5.4, which is a significant drop. However, since starting this medication, I've gained 20 pounds. I'm uncertain if it's due to the drug or not, but either way it's an unwanted side effect as I was the same dress size for 10 years prior to taking this medication.
4Patient Review
9/4/2014 I experience cramping about one to two hours after taking the pill, but my blood sugar levels stay around 100.
3.7Patient Review
3/4/2019 I initially started taking Oseni 25/30mg and stayed on it along with Metformin and Glimipiride. However, within one year I gained 30 pounds while on the medication. Once I stopped taking it, the weight was gone within a couple of months. Recently, a few months ago, I started taking it again and my weight is up 15 lbs already. Therefore, I have decided to stop taking this dangerous drug for good this time and will not go back on it.
3.7Patient Review
2/3/2014 This medication caused me to gain weight.
2.3Patient Review
10/2/2015 At first, this medication was working great and I saw a significant drop in my blood sugar levels. However, after a few months I started experiencing some pretty uncomfortable side effects. I was cold all the time, and then my legs started swelling up painfully. Even taking hydrochlorothiazide didn't help relieve the pressure and pain. So, I had to stop taking Oseni altogether which is too bad because it was really helping with my diabetes.
1.7Patient Review
9/8/2016 Though my daily blood glucose readings did get better, my A1C was still over 7. However, after taking the medication for 10 months I developed congestive heart failure. Could this be a coincidence? Weight loss while on the medication was impossible for me; however, since I stopped taking it 4 weeks ago I've dropped 12 pounds!
Patient Q&A Section about oseni
What are the main side effects of Nesina?
"If you experience severe pain in your upper stomach which spreads to your back, nausea and vomiting, loss of appetite, fast heart rate, itching, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes), you may have liver problems." - Anonymous Online Contributor
Unverified Answer
Is alogliptin the same as metformin?
"Metformin, a biguanide, lowers the amount of sugar your liver releases into your blood, which makes your body respond better to insulin. Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the amount of insulin your body produces." - Anonymous Online Contributor
Unverified Answer
What is oseni used for?
"Osoni is a medication that contains alogliptin and pioglitazone. This medication is used in addition to diet and exercise to improve blood sugar control in people with type 2 diabetes." - Anonymous Online Contributor
Unverified Answer
What is the side effects of alogliptin 25 mg?
"If you have cold-like symptoms, try taking paracetamol or ibuprofen regularly for a few days. If you have headaches, make sure you rest and drink plenty of fluids. If you have a stomach ache or indigestion, try to rest and relax. If you have diarrhoea, drink lots of fluids, such as water or squash, to avoid dehydration. If you have a rash or itchy skin," - Anonymous Online Contributor
Unverified Answer