Oseni

Physical Activity, Type 2 Diabetes, Diet
Treatment
3 FDA approvals
20 Active Studies for Oseni

What is Oseni

AlogliptinThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes mellitus. It is taken in addition to diet, exercise, and other diabetes medications and works by increasing the body’s sensitivity to insulin. This helps the body better absorb glucose and control blood sugar levels. Although Pioglitazone is effective, it has been linked to multiple side effects and warnings, such as congestive heart failure and bladder cancer, and is not as widely used as other alternatives.
Nesinais the brand name
image of different drug pills on a surface
Oseni Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nesina
Alogliptin
2013
26

Approved as Treatment by the FDA

Alogliptin, also known as Nesina, is approved by the FDA for 3 uses which include Type 2 Diabetes and Diet .
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Diet
Used to treat Diet in combination with Pioglitazone
Physical Activity
Used to treat Exercise in combination with Pioglitazone

Effectiveness

How Oseni Affects PatientsPioglitazone helps the body respond better to insulin, making it easier for the body to process glucose. This helps to lower blood glucose levels, insulin levels, and the amount of HbA1c in the body. However, taking pioglitazone can lead to fluid retention, which can worsen congestive heart failure, so it should not be used in patients with heart failure or are at risk of developing it. Additionally, there is evidence that pioglitazone may increase the risk of bladder cancer, so it should not be used in patients with active bladder cancer and should be used with caution in those with
How Oseni works in the bodyPioglitazone helps the body to respond better to insulin, the hormone that controls blood sugar levels. It does this by activating a certain protein in tissues that respond to insulin, like fat, muscle and liver cells. This protein helps to increase the actions of insulin so that it can better control glucose production and use. As a result, pioglitazone can reduce insulin resistance, a condition associated with type 2 diabetes, without causing your body to make more insulin.

When to interrupt dosage

The endorsed measure of Oseni is contingent upon the diagnosed condition, such as Diet, Physical Activity and Type 2 Diabetes. The amount of dosage likewise differs, as per the administration methodology (e.g. Tablet, film coated or Tablet, film coated - Oral) outlined in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Physical Activity
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Diet
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Oseni has seven contraindications, thus it should not be consumed when exposed to any of the conditions in the following table.There are 20 known major drug interactions with Oseni.
Common Oseni Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Alogliptin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Alogliptin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Alogliptin.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Alogliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Alogliptin.
Oseni Toxicity & Overdose RiskThe lowest toxic dose of pioglitazone in mice is 24mg/kg for 4 days, and in rats is 3mg/kg for 6 days. In one reported case of overdosing, a patient took up to 180mg daily for 7 days without any adverse symptoms. If someone overdoses on pioglitazone, medical attention should be sought and the patient's symptoms should be monitored.

Oseni Novel Uses: Which Conditions Have a Clinical Trial Featuring Oseni?

Presently, 300 active studies are being conducted to ascertain the potential of Oseni to manage Type 2 Diabetes, Type 2 Diabetes-related Physical Activity and other conditions.
Condition
Clinical Trials
Trial Phases
Diet
3 Actively Recruiting
Not Applicable
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
190 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3

Oseni Reviews: What are patients saying about Oseni?

5Patient Review
1/24/2015
Oseni for Type 2 Diabetes Mellitus
I've been trying to get my blood sugar levels under control for years now, and this is the first medication that's actually helped me. I was able to reduce my insulin intake by half within the month of taking this drug, and have seen significant improvements in my quality of life as a result. The only downside is that it's quite expensive.
5Patient Review
10/20/2014
Oseni for Type 2 Diabetes Mellitus
Oseni has helped me a lot by reducing my A1C and fasting sugar levels.
5Patient Review
6/29/2014
Oseni for Type 2 Diabetes Mellitus
My fasting blood glucose dropped significantly within a month of starting this medication, and I didn't have to change my diet or exercise routine at all.
4.7Patient Review
10/14/2014
Oseni for Type 2 Diabetes Mellitus
Oseni has been great for my A1C numbers. I recently saw results of 5.4, which is a significant drop. However, since starting this medication, I've gained 20 pounds. I'm uncertain if it's due to the drug or not, but either way it's an unwanted side effect as I was the same dress size for 10 years prior to taking this medication.
4Patient Review
9/4/2014
Oseni for Type 2 Diabetes Mellitus
I experience cramping about one to two hours after taking the pill, but my blood sugar levels stay around 100.
3.7Patient Review
3/4/2019
Oseni for Type 2 Diabetes Mellitus
I initially started taking Oseni 25/30mg and stayed on it along with Metformin and Glimipiride. However, within one year I gained 30 pounds while on the medication. Once I stopped taking it, the weight was gone within a couple of months. Recently, a few months ago, I started taking it again and my weight is up 15 lbs already. Therefore, I have decided to stop taking this dangerous drug for good this time and will not go back on it.
3.7Patient Review
2/3/2014
Oseni for Type 2 Diabetes Mellitus
This medication caused me to gain weight.
2.3Patient Review
10/2/2015
Oseni for Type 2 Diabetes Mellitus
At first, this medication was working great and I saw a significant drop in my blood sugar levels. However, after a few months I started experiencing some pretty uncomfortable side effects. I was cold all the time, and then my legs started swelling up painfully. Even taking hydrochlorothiazide didn't help relieve the pressure and pain. So, I had to stop taking Oseni altogether which is too bad because it was really helping with my diabetes.
1.7Patient Review
9/8/2016
Oseni for Type 2 Diabetes Mellitus
Though my daily blood glucose readings did get better, my A1C was still over 7. However, after taking the medication for 10 months I developed congestive heart failure. Could this be a coincidence? Weight loss while on the medication was impossible for me; however, since I stopped taking it 4 weeks ago I've dropped 12 pounds!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oseni

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the main side effects of Nesina?

"If you experience severe pain in your upper stomach which spreads to your back, nausea and vomiting, loss of appetite, fast heart rate, itching, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes), you may have liver problems."

Answered by AI

Is alogliptin the same as metformin?

"Metformin, a biguanide, lowers the amount of sugar your liver releases into your blood, which makes your body respond better to insulin. Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the amount of insulin your body produces."

Answered by AI

What is oseni used for?

"Osoni is a medication that contains alogliptin and pioglitazone. This medication is used in addition to diet and exercise to improve blood sugar control in people with type 2 diabetes."

Answered by AI

What is the side effects of alogliptin 25 mg?

"If you have cold-like symptoms, try taking paracetamol or ibuprofen regularly for a few days. If you have headaches, make sure you rest and drink plenty of fluids. If you have a stomach ache or indigestion, try to rest and relax. If you have diarrhoea, drink lots of fluids, such as water or squash, to avoid dehydration. If you have a rash or itchy skin,"

Answered by AI

Clinical Trials for Oseni

Have you considered Oseni clinical trials? We made a collection of clinical trials featuring Oseni, we think they might fit your search criteria.
Have you considered Oseni clinical trials? We made a collection of clinical trials featuring Oseni, we think they might fit your search criteria.
Have you considered Oseni clinical trials? We made a collection of clinical trials featuring Oseni, we think they might fit your search criteria.