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What is Oseni
AlogliptinThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes mellitus. It is taken in addition to diet, exercise, and other diabetes medications and works by increasing the body’s sensitivity to insulin. This helps the body better absorb glucose and control blood sugar levels. Although Pioglitazone is effective, it has been linked to multiple side effects and warnings, such as congestive heart failure and bladder cancer, and is not as widely used as other alternatives.
Nesinais the brand name
Oseni Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nesina
Alogliptin
2013
26
Approved as Treatment by the FDA
Alogliptin, also known as Nesina, is approved by the FDA for 4 uses which include Type 2 Diabetes Mellitus and Physical Activity .Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Physical Activity
Used to treat Exercise in combination with Pioglitazone
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Diet
Used to treat Diet in combination with Pioglitazone
Effectiveness
How Oseni Affects PatientsPioglitazone helps the body respond better to insulin, making it easier for the body to process glucose. This helps to lower blood glucose levels, insulin levels, and the amount of HbA1c in the body. However, taking pioglitazone can lead to fluid retention, which can worsen congestive heart failure, so it should not be used in patients with heart failure or are at risk of developing it. Additionally, there is evidence that pioglitazone may increase the risk of bladder cancer, so it should not be used in patients with active bladder cancer and should be used with caution in those with
How Oseni works in the bodyPioglitazone helps the body to respond better to insulin, the hormone that controls blood sugar levels. It does this by activating a certain protein in tissues that respond to insulin, like fat, muscle and liver cells. This protein helps to increase the actions of insulin so that it can better control glucose production and use. As a result, pioglitazone can reduce insulin resistance, a condition associated with type 2 diabetes, without causing your body to make more insulin.
When to interrupt dosage
The endorsed measure of Oseni is contingent upon the diagnosed condition, such as Diet, Physical Activity and Type 2 Diabetes. The amount of dosage likewise differs, as per the administration methodology (e.g. Tablet, film coated or Tablet, film coated - Oral) outlined in the table beneath.Condition
Dosage
Administration
Diet
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Type 2 Diabetes
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Physical Activity
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Oseni has seven contraindications, thus it should not be consumed when exposed to any of the conditions in the following table.There are 20 known major drug interactions with Oseni.Common Oseni Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Alogliptin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Alogliptin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Alogliptin.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Alogliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Alogliptin.
Oseni Toxicity & Overdose RiskThe lowest toxic dose of pioglitazone in mice is 24mg/kg for 4 days, and in rats is 3mg/kg for 6 days. In one reported case of overdosing, a patient took up to 180mg daily for 7 days without any adverse symptoms. If someone overdoses on pioglitazone, medical attention should be sought and the patient's symptoms should be monitored.
Oseni Novel Uses: Which Conditions Have a Clinical Trial Featuring Oseni?
Presently, 300 active studies are being conducted to ascertain the potential of Oseni to manage Type 2 Diabetes, Type 2 Diabetes-related Physical Activity and other conditions.Condition
Clinical Trials
Trial Phases
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Type 2 Diabetes
178 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Oseni Reviews: What are patients saying about Oseni?
5Patient Review
1/24/2015 I've been trying to get my blood sugar levels under control for years now, and this is the first medication that's actually helped me. I was able to reduce my insulin intake by half within the month of taking this drug, and have seen significant improvements in my quality of life as a result. The only downside is that it's quite expensive.
5Patient Review
10/20/2014 Oseni has helped me a lot by reducing my A1C and fasting sugar levels.
5Patient Review
6/29/2014 My fasting blood glucose dropped significantly within a month of starting this medication, and I didn't have to change my diet or exercise routine at all.
4.7Patient Review
10/14/2014 Oseni has been great for my A1C numbers. I recently saw results of 5.4, which is a significant drop. However, since starting this medication, I've gained 20 pounds. I'm uncertain if it's due to the drug or not, but either way it's an unwanted side effect as I was the same dress size for 10 years prior to taking this medication.
4Patient Review
9/4/2014 I experience cramping about one to two hours after taking the pill, but my blood sugar levels stay around 100.
Patient Q&A Section about oseni
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the main side effects of Nesina?
"If you experience severe pain in your upper stomach which spreads to your back, nausea and vomiting, loss of appetite, fast heart rate, itching, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes), you may have liver problems."
Answered by AI
Is alogliptin the same as metformin?
"Metformin, a biguanide, lowers the amount of sugar your liver releases into your blood, which makes your body respond better to insulin. Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the amount of insulin your body produces."
Answered by AI
What is oseni used for?
"Osoni is a medication that contains alogliptin and pioglitazone. This medication is used in addition to diet and exercise to improve blood sugar control in people with type 2 diabetes."
Answered by AI
What is the side effects of alogliptin 25 mg?
"If you have cold-like symptoms, try taking paracetamol or ibuprofen regularly for a few days. If you have headaches, make sure you rest and drink plenty of fluids. If you have a stomach ache or indigestion, try to rest and relax. If you have diarrhoea, drink lots of fluids, such as water or squash, to avoid dehydration. If you have a rash or itchy skin,"
Answered by AI
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