Bioactive Sleeve for Recovery

Age: 18+
Sex: Male
Trial Phase: Academic
Sponsor: Stanford University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines whether a special sleeve made from bioactive fabric can reduce arm soreness in baseball pitchers. Players will alternate between using a bioactive sleeve and a regular sleeve after games to determine if the bioactive sleeve reduces soreness, potentially preventing more serious injuries. This trial is open to Stanford baseball players who frequently experience arm soreness after pitching. As an unphased trial, participants can explore innovative solutions for arm soreness and contribute to research that may benefit future athletes.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this bioactive sleeve is safe for collegiate baseball players?

Previous studies have shown that bioactive sleeves are safe. Research on bioactive stents, which function similarly, also indicates general safety for patients. However, some studies suggest that materials in these sleeves might cause skin irritation or allergic reactions in a small number of people. These reactions are uncommon and usually mild. Overall, the sleeve is considered safe, but individuals with sensitive skin should exercise caution.12345

Why are researchers excited about this trial?

The Bioactive Sleeve is unique because it offers a novel approach to aiding recovery for pitchers by using bioactive materials that may enhance healing while they sleep. Unlike traditional methods like rest, physical therapy, or medication, which are often used to manage arm fatigue and injuries, this sleeve works passively overnight. Researchers are excited about its potential to speed up recovery and improve performance without the need for additional active intervention. This could be a game-changer for athletes looking for effective, low-effort recovery options.

What evidence suggests that this trial's treatments could be effective for reducing arm soreness in baseball pitchers?

Research has shown that bioactive sleeves can help athletes recover more effectively after exercise. In one study, 91% of users reported better recovery with a bioactive sleeve. Similar products, such as compression garments, have proven effective in reducing muscle soreness and swelling. These benefits help athletes feel and perform better after intense activity. In this trial, participants will use either a Bioactive Sleeve or a Control Sleeve. Early evidence suggests that wearing a bioactive sleeve might reduce arm soreness for pitchers.36789

Who Is on the Research Team?

MF

Michael Freehill, MD

Principal Investigator

Stanford University

Are You a Good Fit for This Trial?

This trial is for collegiate baseball players who experience arm soreness after pitching. It aims to see if wearing a special sleeve can help with recovery. Players must be actively participating in the season to join.

Inclusion Criteria

Stanford Baseball Player

Exclusion Criteria

Not applicable.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use a bioactive fabric sleeve or control sleeve on the throwing arm after each game they pitch

6 months
Regular assessments throughout the baseball season

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Bioactive Sleeve
  • Control Sleeve
Trial Overview The study is testing two types of sleeves: one is a regular control sleeve, and the other is a bioactive fabric sleeve that may improve muscle recovery. The goal is to compare how each affects arm soreness after games.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Control Sleeve then Bioactive SleeveExperimental Treatment2 Interventions
Group II: Bioactive Sleeve then Control SleeveExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+

Challenger Health, LLC

Collaborator

Trials
1
Recruited
10+

Published Research Related to This Trial

This feasibility study involves 50 patients undergoing total knee arthroplasty to assess the impact of a short-stretch compression bandage on post-operative knee swelling, pain, and function compared to a standard bandage.
The study aims to gather preliminary data on the effectiveness of compression bandages, which could inform a larger trial, as current clinical data on their efficacy in knee surgery is limited.
Short-stretch inelastic compression bandage in knee swelling following total knee arthroplasty study (STICKS): study protocol for a randomised controlled feasibility study.Brock, TM., Sprowson, AP., Muller, S., et al.[2018]
A large randomized controlled trial (RCT) involving 2600 adult patients will assess the efficacy of short-stretch compression bandages compared to standard bandaging after total knee arthroplasty, aiming to detect a significant improvement in patient-reported outcomes at 52 weeks.
The study will evaluate multiple outcomes, including knee pain and function (measured by the Oxford Knee Score), quality of life (EQ-5D scores), and complications, contributing valuable data to guide clinical practices in post-surgical care.
Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial.Cook, L., Northgraves, MJ., Fairhurst, C., et al.[2020]

Citations

Bioactive Sleeve for Recovery · Info for ParticipantsDifferent recovery modalities such as a bioactive fabric sleeve may give pitchers a recovery advantage throughout a baseball season.
Reparel's bioactive sleeve improves recovery outcomes for ...In this clip from Ortho Summit 2025, Dr. Ariana De Mers shares how our bioactive sleeve is changing recovery in her practice: ✔️ 91% of ...
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/28434152/
Compression Garments and Recovery from ExerciseConclusion: The largest benefits resulting from CG were for strength recovery from 2 to 8 h and >24 h. Considering exercise modality, compression most ...
Effectiveness of Recovery Strategies After Training and ...Data Synthesis​​ The outcomes of different recovery strategies were evaluated in terms of athletic performance and physiological and self- ...
(PDF) Are compression garments effective for the recovery ...The meta-analysis reported evidence that compression garments reduced perceived muscle soreness and swelling, without reducing metabolic waste ...
Material Safety Data SheetPersonal Precautions. Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the ...
Safety Data Sheet1. May cause an allergic skin reaction. Precautionary Statements. P261: Avoid breathing vapor. P280: Wear protective gloves and eye protection.
SAFETY DATA SHEETHazard Statements. H315. Causes skin irritation. H317. May cause an allergic skin reaction. H319. Causes serious eye irritation. H401. Toxic to ...
Investigating the Efficacy of Bioactive Sleeves with ...The results of our study indicate that application of bioactive nano-semiconductor sleeves had a significant effect in alleviating Achilles ...
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