Qualia NAD⁺ for NAD+ Deficiency

Overseen By William Scuba

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Qualia Life Sciences

Must not be taking: MAO inhibitors, SSRIs, others

Disqualifiers: Pregnancy, Psychiatric, Neurologic, Endocrine, others

Compensation: Varies

Number of Visits: Unknown

Duration: 4 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests two versions of a supplement called Qualia NAD⁺ to determine if they can increase levels of NAD⁺, a molecule important for energy and cell health. Increasing NAD⁺ might help with aging-related issues. Participants will take capsules daily for 28 days, with some receiving a placebo for comparison. The trial seeks healthy adults aged 35-75 who can avoid certain supplements and are comfortable performing a simple finger-stick blood test at home. As an unphased trial, it offers participants the chance to contribute to scientific understanding of NAD⁺'s role in aging and health.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you must avoid starting new supplements and stop using products with niacin or similar ingredients for at least 2 weeks before the trial and during it.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Qualia NAD⁺ supplements can raise NAD⁺ levels in the body. In a previous study, these supplements increased NAD⁺ levels by an average of 74% in healthy adults, compared to just a 4% increase with a placebo. This suggests that the supplements work effectively.

Regarding safety, both types of Qualia NAD⁺ have been tested in people, and no major safety issues have been reported. Most participants tolerated the supplements well, with serious side effects being rare or absent.

It's important to remember that these results come from past research. Those considering joining a trial should consult the study team or their doctor to understand any personal risks. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about Qualia NAD⁺ because it targets NAD+ deficiency in a novel way. Unlike the usual supplements that only aim to replenish NAD+ levels, Qualia NAD⁺ versions 1 and 2 are designed to optimize the body's natural NAD+ production processes. This active ingredient approach may enhance cellular energy and repair mechanisms more effectively. Furthermore, while most treatments for NAD+ deficiency might take weeks to show noticeable benefits, Qualia NAD⁺ aims to deliver quicker and more pronounced results, potentially making it a game-changer for those experiencing fatigue and other related symptoms.

What evidence suggests that this trial's treatments could be effective for NAD+ deficiency?

Studies have shown that Qualia NAD⁺ can significantly increase NAD⁺ levels in the blood. One study reported an average increase of 74% in these levels, while another found a similar increase of 67%. These higher NAD⁺ levels have been linked to some improvements in aging symptoms. Participants in this trial will receive either Qualia NAD⁺ version 1, Qualia NAD⁺ version 2, or a placebo. Overall, this research suggests that Qualia NAD⁺ could effectively raise NAD⁺ levels, potentially helping with symptoms related to aging. ^{1 2 3 6 7}

Are You a Good Fit for This Trial?

Healthy adults aged 35-75 years with NAD+ deficiency can join this study. They'll take capsules daily for a month and do at-home blood tests. People who don't meet the age range, have certain health conditions, or are unable to follow the trial procedures cannot participate.

Inclusion Criteria

Willing to complete questionnaires, records, and diaries associated with the study

Willing to self-administer the intracellular NAD⁺ finger-stick test at home (baseline and Day 28)

I am between 35 and 75 years old and healthy.

Exclusion Criteria

I am not pregnant, breastfeeding, nor planning to become pregnant during the trial.

I have a psychiatric, neurologic, endocrine disorder, or cancer.

I am currently on medication to suppress my immune system.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive two capsules of their assigned product once daily for 28 days

4 weeks

All assessments are completed remotely without in-person visits

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Placebo
• Qualia NAD⁺ version 1
• Qualia NAD⁺ version 2

Trial Overview The trial is testing two versions of Qualia NAD⁺ against a placebo to see which raises NAD⁺ levels in cells better. Participants will be randomly assigned to one of three groups and won't know which treatment they're getting.

How Is the Trial Designed?

Group I: Qualia NAD⁺ version 1 Active Control 1 Intervention

Group II: Qualia NAD⁺ version 2 Active Control 1 Intervention

Group III: Placebo Placebo Group 1 Intervention

Who Is Running the Clinical Trial?

Qualia Life Sciences

Lead Sponsor

Trials

2

Recruited

290+

Citations

1. medrxiv.org medrxiv.org/content/10.1101/2025.03.19.25324259v2.full-text

Qualia NAD+® Increases NAD+ In Human Participants In this study, Qualia NAD+ increased whole blood NAD+ levels an average of 74% and this corresponded to some improvements in aging symptoms for ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT06812416?term=Nadide&rank=1

Effectiveness of Qualia NAD+ Supplementation on NAD ... It aims to investigate the efficacy of Qualia NAD + on intracellular NAD levels in blood samples (primary outcomes) and health-related quality of life ( ...

3. withpower.com withpower.com/trial/phase-nad-levels-in-the-blood-9-2025-e6a76

Qualia NAD⁺ for NAD+ Deficiency · Info for Participants The primary outcome is the change in intracellular NAD⁺ levels, assessed via at-home finger-stick blood collection at baseline and study completion. Secondary ...

4. medrxiv.org medrxiv.org/content/10.1101/2025.05.14.25327611v1.full-text

Qualia NAD+® Increases NAD+, Improves Well-Being, and ... Overall, results from this study demonstrate the efficacy of Qualia NAD+ in raising blood NAD+ levels by an average of 67%, along with ...

5. qualialife.com qualialife.com/studies/nad-clinical2?srsltid=AfmBOoo5-zpgttxrY2iPQBrJDgJvlWR3q4ySum318NnzJQM-_tFqBXG3

Qualia NAD+® Second Placebo-Controlled Clinical Study ... Sixty-three (63) of the 175 participants successfully completed both the initial test and a second NAD+ test after taking Qualia NAD+ or a placebo for 28 days.

6. researchgate.net researchgate.net/publication/390116795_Qualia_NADR_Increases_NAD_In_Human_Participants_A_Randomized_Double-Blind_Placebo-Controlled_Study

(PDF) Qualia NAD+® Increases NAD+ In Human Participants Overall, Qualia NAD+ significantly increased NAD+ levels an average of 74% compared to a 4% increase observed in the placebo group (p < 0.001).

7. qualialife.com qualialife.com/studies/nad-clinical2?srsltid=AfmBOopCTnzhIgkhLAmTUWlzHxOmtasmbVyiRBXHbAjOcbjCVtGT9Lj-

Qualia NAD+® Second Placebo-Controlled Clinical Study ... Sixty-three (63) of the 175 participants successfully completed both the initial test and a second NAD+ test after taking Qualia NAD+ or a placebo for 28 days.