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What is Orapred
Prednisolone phosphateThe Generic name of this drug
Treatment SummaryPrednisolone phosphate is a steroid medication used to reduce inflammation and suppress the immune system. It is also used to treat certain types of tumors. The drug was approved by the FDA in 1973 and can produce effects such as constricting blood vessels.
Pediapredis the brand name
Orapred Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pediapred
Prednisolone phosphate
1986
71
Approved as Treatment by the FDA
Prednisolone phosphate, also called Pediapred, is approved by the FDA for 14 uses such as Endocrine Disorders and Allergic Conditions .Endocrine Disorders
Allergic Conditions
Neoplastic Disease
Multiple Sclerosis
Disease
Ocular Inflammation
Ophthalmia, Sympathetic
Gastroenteritis
Uveitis
Respiratory Diseases
Temporal Arteritis
Dermatological Disease
Collagen Diseases
Swollen feet or ankles
Effectiveness
How Orapred Affects PatientsPrednisolone works by blocking certain signals in the body that can lead to inflammation. It is only active in the body for a short time (2-4 hours), but the amount prescribed can be much higher than what the body makes naturally. People taking prednisolone should be aware of the risk of suppressing the body's hormone system and becoming more vulnerable to infections.
How Orapred works in the bodyCorticosteroids work to reduce inflammation in the body. They do this by affecting the flow of blood vessels and blocking white blood cells from travelling to sites of inflammation. Corticosteroids also change how certain genes are expressed, causing anti-inflammatory effects. Low doses reduce inflammation while high doses weaken the immune system. If taken for a long time, corticosteroids can cause an increase in sodium and decrease in potassium levels.
When to interrupt dosage
The proposed dosage of Orapred is contingent upon the indicated affliction, including Uveitis, Ocular Inflammation and Ophthalmia, Sympathetic. The measure of dosage is set by the method of administration specified in the table below.Condition
Dosage
Administration
Ophthalmia, Sympathetic
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Uveitis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Urinary Tract Infection (UTI)
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Gastroenteritis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Endocrine Disorders
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Collagen Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Temporal Arteritis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Ocular Inflammation
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Neoplastic Disease
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Swollen feet or ankles
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Dermatological Disease
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Disease
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Multiple Sclerosis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Allergic Conditions
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Respiratory Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Warnings
Orapred has one contraindication and should not be consummated together with the conditions given in the following table.Orapred ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Prednisolone Phosphate may interact with Pulse Frequency
Common Orapred Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Prednisolone phosphate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Prednisolone phosphate.
Aldesleukin
Major
The therapeutic efficacy of Aldesleukin can be decreased when used in combination with Prednisolone phosphate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Prednisolone phosphate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Prednisolone phosphate.
Orapred Toxicity & Overdose RiskNot much is known about acute Glucocorticoid overdose. Chronic overdose, however, can cause mental symptoms, a round face, fat deposits, and water retention. In case of an acute overdose, the patient should be given their stomach contents to vomit or have it removed with a tube, followed by supportive treatment. If the overdose is chronic, the dose should be reduced temporarily or taken every other day.
Orapred Novel Uses: Which Conditions Have a Clinical Trial Featuring Orapred?
115 active clinical trials are currently underway to assess the potential of Orapred to ameliorate Ocular Inflammation, Uveitis and Sympathetic Ophthalmia.Condition
Clinical Trials
Trial Phases
Allergic Conditions
0 Actively Recruiting
Neoplastic Disease
1 Actively Recruiting
Phase 1
Multiple Sclerosis
0 Actively Recruiting
Ophthalmia, Sympathetic
0 Actively Recruiting
Disease
0 Actively Recruiting
Temporal Arteritis
0 Actively Recruiting
Endocrine Disorders
0 Actively Recruiting
Collagen Diseases
0 Actively Recruiting
Dermatological Disease
0 Actively Recruiting
Ocular Inflammation
3 Actively Recruiting
Phase 2, Phase 4, Phase 3
Respiratory Diseases
3 Actively Recruiting
Not Applicable
Uveitis
15 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Gastroenteritis
29 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Orapred Reviews: What are patients saying about Orapred?
4.3Patient Review
6/11/2013 My daughter experienced some muscle soreness after taking this medication. It was bad enough that it was uncomfortable for her to even be touched.
4Patient Review
1/23/2010 I've been very pleased with this medication for my child's asthma. They don't become as hyperactive, which was a problem we experienced when using albuterol alone. The only downsides are that they sweat more and have increased appetite/thirst, but those are manageable compared to the benefits.
4Patient Review
5/31/2009 This cough medicine was really effective for my son.
3.7Patient Review
6/7/2011 Orapred has been effective at stopping my son's cough from croup, but he experiences severe side effects like crying and rubbing his eyes and ears obsessively. I'm glad it's only a 3 day course.
3.7Patient Review
11/29/2009 My child became more hyperactive and began to hallucinate about bugs after taking this medication. Even though it got rid of the poison ivy, I would not recommend it for children.
3.3Patient Review
10/29/2008 My son needed this medication to recover from a severe asthma attack. It's syrup form is quite difficult to get him to take because it likely tastes awful, and he normally does well with taking medicines. As a side effect he's been extremely hyper, has reduced appetite and diarrhea, but this could be due to combination with Albuterol and Pulmicort.
2.7Patient Review
8/11/2009 My son has ADHD and asthma. When he takes orapred for his asthma, his ADHD becomes much more difficult to control. He is on medication ( focalin) for ADHD and I wonder if the combination of these two drugs creates this type of reaction in other children.
2.3Patient Review
10/18/2009 My son was on orapred for 5 days. Not only were his moods extremely erratic, but he would vomit in the evening only. Could the vomiting be another side effect? I know nausea can be a side effect, but vomiting too?
2.3Patient Review
9/28/2007 I didn't see the results I wanted as quickly as I would have liked. The nurse actually gave me a script and left the room, suggesting I come back if the problem did not improve. Not great service or science!
1.7Patient Review
12/7/2009 It was pretty nightmarish trying to get my seven-month-old to swallow this. I can't imagine why anyone would think that's a reasonable amount for such a young child. We're going to try Veripred tomorrow instead.
1Patient Review
2/22/2009 I believe that one teaspoonful daily is too much for my 9-month-old granddaughter.
Patient Q&A Section about orapred
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Orapred a steroid?
"Orapred ODT is a medicine that contains the active ingredient prednisolone, which is a type of medicine known as a corticosteroid. Corticosteroids are medicines that are used to help reduce inflammation in the body."
Answered by AI
Is Orapred the same as prednisone?
"Prednisone and prednisolone are man-made steroids that are similar to cortisol, a hormone that your body produces naturally.
Brand names of prednisone include Prednisone Intensol and Rayos. Brand names of prednisolone include Flo-Pred, Pediapred, Orapred, and Orapred ODT. Prednisone and prednisolone are man-made steroids that are similar to cortisol. Both drugs are used to treat a variety of conditions, including allergies, autoimmune diseases, and skin conditions."
Answered by AI
What is Orapred used for?
"This drug is used to treat a variety of conditions that involve inflammation or an overactive immune system, including arthritis, blood disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. It works by depressing the immune system, which decreases the inflammatory response and relieves symptoms such as pain, swelling, and allergic reactions."
Answered by AI