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What is Olumiant
BaricitinibThe Generic name of this drug
Treatment SummaryBaricitinib is a medication used to treat moderate to severe rheumatoid arthritis. It works by blocking the action of two proteins, Janus kinase 1 and 2, which are part of an overactive inflammatory pathway. By blocking these proteins, baricitinib reduces inflammation and can help prevent joint damage caused by the condition. It was approved in the EU in 2017 and is marketed as Olumiant. In November 2020, Baricitinib in combination with remdesivir was given emergency approval by the FDA to treat COVID-19.
Olumiantis the brand name
Olumiant Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Olumiant
Baricitinib
2018
3
Approved as Treatment by the FDA
Baricitinib, also known as Olumiant, is approved by the FDA for 3 uses including Tumor Necrosis Factor Inhibitors and Rheumatoid Arthritis .Tumor Necrosis Factor Inhibitors
Helps manage Inadequate response or intolerance to TNF blockers
Rheumatoid Arthritis
Helps manage severe, active Rheumatoid arthritis
moderate, active Rheumatoid arthritis
Helps manage moderate, active Rheumatoid arthritis
Effectiveness
How Olumiant Affects PatientsBaricitinib is a medicine used to treat rheumatoid arthritis. In animal studies, it was seen to reduce inflammation, protect joint and bone health, and not have any negative effects on the immune system or blood. Additionally, it has been found to lower the levels of antibodies and a protein (C-reactive protein) in people with rheumatoid arthritis.
How Olumiant works in the bodyJanus kinases (JAKs) are enzymes that activate signals from cytokines and growth factor receptors in the body. They trigger genes that cause inflammation and an autoimmune response. Baricitinib is a medication that works to block JAKs from activating these signals. It stops the inflammatory genes from turning on, and it has also been shown to decrease cell proliferation and trigger cell death in mutated cells.
When to interrupt dosage
The proposed measure of Olumiant is contingent upon the determined condition, such as moderate, active Rheumatoid arthritis, Antirheumatic Agents and Mechanical ventilation. Dosage likewise shifts as per the methodology of application featured in the table below.Condition
Dosage
Administration
moderate, active Rheumatoid arthritis
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Dermatitis, Atopic
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hospitalizations
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Oxyhemoglobin
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Tumor Necrosis Factor Inhibitors
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Dermatitis, Atopic
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
candidate for systemic therapy
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Alopecia Areata (AA)
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
COVID-19
2.0 mg, , 1.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Olumiant ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Baricitinib may interact with Pulse Frequency
Common Olumiant Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Baricitinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Baricitinib is combined with Acteoside.
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Baricitinib.
Begelomab
Major
The risk or severity of adverse effects can be increased when Baricitinib is combined with Begelomab.
Bleselumab
Major
The risk or severity of adverse effects can be increased when Baricitinib is combined with Bleselumab.
Olumiant Toxicity & Overdose RiskTests have shown that the lowest toxic dose of the drug in mice is 1820g/kg and 5096g/kg in rats. Studies have also found that taking doses up to 40mg in a single dose or 20mg daily for 10 days did not cause any significant side effects. After a single dose of 40mg, 90% of the drug is expected to be eliminated from the body within 24 hours. If someone overdoses on the drug, they should be monitored for any signs of adverse reactions, and treated accordingly.
Olumiant Novel Uses: Which Conditions Have a Clinical Trial Featuring Olumiant?
74 active trials are now in progress to explore the potential of Olumiant in managing Coronavirus Disease 2019 (COVID‑19), Rheumatoid Arthritis and Hospitalized Patients.Condition
Clinical Trials
Trial Phases
Hospitalizations
2 Actively Recruiting
Not Applicable
Tumor Necrosis Factor Inhibitors
0 Actively Recruiting
Dermatitis, Atopic
0 Actively Recruiting
Dermatitis, Atopic
0 Actively Recruiting
Rheumatoid Arthritis
0 Actively Recruiting
moderate, active Rheumatoid arthritis
0 Actively Recruiting
Alopecia Areata (AA)
1 Actively Recruiting
Phase 1, Phase 2
Oxyhemoglobin
3 Actively Recruiting
Not Applicable, Phase 1
candidate for systemic therapy
0 Actively Recruiting
COVID-19
36 Actively Recruiting
Phase 2, Early Phase 1, Phase 3, Not Applicable, Phase 1, Phase 4
Olumiant Reviews: What are patients saying about Olumiant?
4.3Patient Review
2/21/2022 I was able to recover from very severe RA symptoms along with heavy bone destruction. Recovery took few months but was stable .
3Patient Review
7/9/2020 I'm 43 and have had RA since I was 29. I've been on all the meds you can relate to RA, and I'm currently still taking Plaquenil and Sulfasalazine. Three weeks ago, I started Olumiant 4mg . After one week, I started vomiting and got constipated. In week three, I started getting severe upper abdominal pain and ended up in ED with severe Pancreatitis. WILL NEVER TAKE IT AGAIN. If you gets upper abdominal pain while on this medication, go straight to ED.
2.7Patient Review
8/22/2019 I used this for 11 days and ended up with a whole host of problems: nausea, UTI, sinus infection, and hemorrhoids. So I went off it to take antibiotics and I haven't looked back since.
2.3Patient Review
7/31/2021 Whenever I would get a very small scratch or poke on my skin it would turn into a hole about the size of a dime. Very sore and I'm still trying to get them healed up. They take months and hurt so bad you can barely touch them. I've been on antibiotics and stopped olumiant. So far I still have the sores after a couple of months.
2Patient Review
12/27/2018 I've only been on Olumiant for a couple weeks, and the main side effects I've experienced are nausea and vomiting. I haven't eaten anything substantial in days, and all that comes up is water at this point. I was previously on Humira, so it'll be interesting to see if there's a difference in pain levels. I'm also on Methotrexate.
2Patient Review
11/9/2021 I was extremely disappointed with this medication's ineffectiveness on my RA. Not only that, but I now need a cervical spine fusion because of it. Be very careful of the doctors who push this treatment; my rheumatologist received it for free, then made me pay $1,500 for it. When I complained about the extreme pain in my neck, he refused to change the medication. This caused irreversible damage in multiple locations.
1.7Patient Review
10/24/2021 This medication was unfortunately very harmful to me, leading to instability in my joints and further damage. I needed surgery as a result of taking this for seven months at a dosage of 4mg per day. My treating physician was unhelpful, continuing the therapy even though he knew it wasn't working and was actually causing harm. Be aware of the potential risks before starting this medication.
Patient Q&A Section about olumiant
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Olumiant approved for alopecia?
"The FDA has approved Olumiant for the treatment of severe alopecia areata. Olumiant is a once-daily pill that is taken orally."
Answered by AI
What kind of drug is Olumiant?
"The drug Baricitinib, also known as Olumiant, is used to treat rheumatoid arthritis by blocking the action of Janus kinase enzymes which are involved in the inflammation that causes the symptoms of rheumatoid arthritis."
Answered by AI
What is Olumiant medication for?
"Olumiant (baricitinib) is a medicine that needs a prescription from a doctor. It is used to treat adults with arthritis that is moderately to severely active. This is after treatment with 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, but did not work well enough or were not tolerated."
Answered by AI
What is Olumiant 4 mg used for?
"There are recessed areas on each side of the tablets. Baricitinib is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs."
Answered by AI