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Probiotics for Obesity

N/A
Recruiting
Led By Arpana Gupta, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 18-50
Be between 18 and 65 years old
Must not have
Use of probiotics in the last 3 months
Drastic weight loss (more than 10lbs over the preceding 2 months)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up collected three times, once at baseline appointment (week 0), once at mid-study appointment (week 6), and once at the final 3month appointment (week 12).

Summary

This trial tested new probiotics to help curb obesity: current standard of care for obesity and food addiction is difficult & lacks efficacy; bariatric surgery is an option but has barriers; new probiotics may provide an alternative way to reduce weight.

Who is the study for?
Adults aged 18-50 with a BMI of 25-40, who are not pregnant or nursing. Excluded if they have Type 1 diabetes, untreated thyroid disease, neurological issues, weigh over 400lbs, had certain abdominal surgeries, major medical conditions as determined by the study doctor, chronic pain or active psychiatric illness including eating disorders in the last two years.
What is being tested?
This trial is testing whether probiotics can help people lose weight compared to a placebo. It's for those who find current obesity treatments ineffective and want to avoid bariatric surgery due to its risks and recovery time.
What are the potential side effects?
Probiotics are generally safe with minimal side effects. Unlike some obesity medications that may cause adverse reactions, probiotics typically do not lead to significant discomfort or health issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 50 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have used probiotics in the last 3 months.
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I have lost more than 10 pounds in the last 2 months without trying.
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I have had surgery on my stomach or intestines, including for weight loss.
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I have a neurological condition.
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I am not using birth control and may plan to get pregnant during the study.
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I have lost more than 10lbs or changed my diet significantly in the last 2 months.
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I have type 1 diabetes and need insulin.
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I have a thyroid condition that hasn't been treated.
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I am not taking any medications listed as excluded.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~collected three times, once at baseline appointment (week 0), once at mid-study appointment (week 6), and once at the final 3month appointment (week 12).
This trial's timeline: 3 weeks for screening, Varies for treatment, and collected three times, once at baseline appointment (week 0), once at mid-study appointment (week 6), and once at the final 3month appointment (week 12). for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Differences in metabolite concentrations pre & post intervention - Blood
Differences in metabolite concentrations pre & post intervention - Stool
Differences in microbiome levels pre & post intervention - Blood
+1 more
Secondary study objectives
Anthropometrics - BMI
Anthropometrics - waist and hip circumference
Changes in Autonomic Measures - Diastolic & Systolic blood pressure
+9 more
Other study objectives
Differences in Multimodal Brain Signatures

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: ProbioticActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,559 Previous Clinical Trials
10,258,771 Total Patients Enrolled
Arpana Gupta, PhDPrincipal InvestigatorThe Regents of the University of California, Los Angeles
3 Previous Clinical Trials
670 Total Patients Enrolled
Tien Dong, MD, PhDPrincipal InvestigatorThe Regents of the University of California, Los Angeles
~48 spots leftby Dec 2025
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