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Red Blood Cell Transfusion Strategies for ECMO Patients (TITRE Trial)
TITRE Trial Summary
This trial will compare two different transfusion strategies for children on ECMO support to see which one leads to better outcomes.
TITRE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTITRE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2012 Phase 3 trial • 110 Patients • NCT01167582TITRE Trial Design
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Who is running the clinical trial?
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- I was put on ECMO at a different hospital and then moved to a trial site.I have a blood disorder affecting my hemoglobin.My baby was born before 37 weeks of pregnancy.I have discussed or decided on care limits after starting ECMO treatment.I was younger than 6 years old when I received ECMO treatment.I have a bleeding disorder I was born with.I was first treated with VV-ECMO and then switched to VA ECMO.
- Group 1: Indication-based red blood cell transfusion strategy
- Group 2: Center-specific hemoglobin/hematocrit threshold-based red blood cell transfusion strategy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are participants being accepted for this research venture currently?
"According to clinicaltrials.gov, this medical study is not presently enrolling patients. Although first posted on January 1st 2023 and amended June 27th 2022, there are 31 other trials currently in recruitment mode."
What outcomes is this experiment attempting to demonstrate?
"This clinical trial's primary goal is to assess the Bayley Infant Scales of Development, 4th edition (Bayley-4) over a specified period. Secondary objectives include quantifying ICU free days and total blood product administration as well as measuring mixed venous oxygen saturation."
Would I be eligible to join this clinical investigation?
"The scope of this trial requires that participants have multiple organ failure and are within the age range of 1 day to 6. Up to 228 individuals could potentially qualify for acceptance into the study."
Does this clinical trial accept participants who are over 55 years of age?
"As outlined in the entry requirements, the minimum age to join this study is 1 day and no participant should exceed 6 years old."
In how many settings is the experiment being conducted?
"Currently, the trial is recruiting from 18 locations including Children's Hospital Colorado in Aurora and Washington University in St. Louis School of Medicine. Additionally, there are an additional 15 sites spread across the United States offering this medication to patients."
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