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What is Norvasc
AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a drug used to treat high blood pressure and chest pain (angina). It belongs to a group of drugs called dihydropyridine calcium channel blockers, which are known for their selectivity in targeting the peripheral blood vessels. This reduces the side effects that other calcium channel blockers can have on the heart. Amlodipine has anti-oxidant properties and can help increase the amount of nitric oxide in the body, which helps to lower blood pressure. It also has the advantage of being taken once daily.
Norvascis the brand name
Norvasc Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199
Approved as Treatment by the FDA
Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like angiographically documented disease and Chronic Stable Angina Pectoris .angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Effectiveness
How Norvasc Affects PatientsAmlodipine blocks certain calcium channels in the body and helps to relax the blood vessels, lowering blood pressure. This drug can be taken once a day and the effects last for up to 24 hours. Amlodipine does not noticeably change heart rate or electrical activity in the heart, and when taken with other medications like beta-blockers, it will not cause any additional changes. When taken by people with angina, it can help reduce chest pain, increase exercise time, and decrease the need for nitroglycerin tablets.
How Norvasc works in the bodyAmlodipine works to lower blood pressure by blocking calcium from entering certain cells. This reduces the amount of tension in the blood vessels and reduces the force of blood flow, reducing your blood pressure. For angina, amlodipine works by widening the arteries that supply your heart with oxygen, reducing the work and energy needed by your heart and improving oxygen delivery. It also helps to relax your coronary arteries and reduce any spasms that may be present.
When to interrupt dosage
The prescribed measure of Norvasc is subject to the specified condition, including inadequate reply to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage is contingent upon the administration approach (e.g. Tablet, film coated or Tablet) delineated in the table beneath.Condition
Dosage
Administration
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
angiographically documented disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease (CAD)
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Chronic Stable Angina Pectoris
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Mixed Dyslipidaemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Warnings
Norvasc ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
Common Norvasc Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Norvasc Toxicity & Overdose RiskThe highest toxic dose of amlodipine in mice has been found to be 37mg/kg. An overdose may cause high levels of peripheral dilation and an increased heart rate. Severe and long-lasting low blood pressure, which can lead to shock and death, has also been reported. Studies have not shown any cancer-causing effects, genetic or chromosomal changes, or fertility issues in rats and mice given amlodipine. The safety of amlodipine during pregnancy and lactation has not been confirmed, so it should only be used if the benefits outweigh the risks. Amlod
Norvasc Novel Uses: Which Conditions Have a Clinical Trial Featuring Norvasc?
46 active trials are currently underway to assess the effectiveness of Norvasc in alleviating High Cardiovascular Risk, Vasospastic Angina and Coronary Artery Disease (CAD).Condition
Clinical Trials
Trial Phases
inadequate response to diet
0 Actively Recruiting
Hypertensive disease
2 Actively Recruiting
Not Applicable
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Mixed Dyslipidaemia
0 Actively Recruiting
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Vasospastic Angina
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Pharmacotherapy
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
angiographically documented disease
0 Actively Recruiting
Lifestyle Modification
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Norvasc Reviews: What are patients saying about Norvasc?
3.3Patient Review
3/8/2018 I was extremely hot constantly...I thought I might be experiencing hot flashes. My heart would race. After just three days of transitioning to this new medication, though, I felt something I haven't in months: chilly!
3Patient Review
2/29/2020 After starting this medication, I experienced a rapid weight gain and neuropathy. Additionally, tinnitus made it difficult to hear, and severe shortness of breath meant that even minor exertion was very difficult. As a result, the doctor took me off the medication 5 days ago. However, since then I have felt horrible- like I am having a heart attack.
3Patient Review
8/10/2021 I was prescribed 5mg amlodipine, which was increased to 10mg after three days. I began to experience arrhythmia and bradycardia, so I switched back to the lower dosage of 5mg. Within two days, I felt much better. However, my blood pressure did increase as a result.
2.7Patient Review
9/12/2020 I felt really breathless and anxious while taking this medication, and my heart rate would spike randomly which was very unpleasant.
2.3Patient Review
5/9/2017 I was warned about the dizziness, and it finally happened after seven days. However, my chest pain has gone away completely. So I guess it's worth it?
2.3Patient Review
7/17/2017 I experienced swelling in my hands, feet, and abdomen as well as flushing.
2.3Patient Review
7/30/2017 Norvasc did lower my blood pressure, but after just two weeks I started experiencing some serious side effects. My feet and ankles swelled up and I was in a lot of pain. I stopped taking the drug ten days ago and most of the side effects have gone away, but my blood pressure is back up to 145/80. I'm going to look for a natural method to lower my blood pressure that doesn't come with such nasty side effects.
2.3Patient Review
8/17/2020 I took this for years with no problems, but when my doctor upped the dosage from 5 to 10 mg, I started having issues with gum overgrowth that required surgery to fix.
2.3Patient Review
12/19/2017 I've been taking Norvasc for a few years now and recently started noticing severe swelling in my lower extremities. This led to a hospital visit.
1.7Patient Review
9/15/20161.7Patient Review
9/20/2019 After five days of use, I experienced a sudden and significant loss of hearing, as well as incessant ringing in my ears. Additionally, my skin has been itching all over my body.
1Patient Review
9/3/2018 I was on this for five days before I started noticing my body slowly swelling up, becoming bruised, and my face turning red. Once I realized what was happening, I stopped taking it immediately and saw the symptoms disappear within just a few days. Honestly, I think the cure is worse than the condition.
1Patient Review
7/11/2020 Within a week of taking this medication, I suddenly fainted and hit my head. This resulted in a seizure. I don't know if it was the Amlodipine or not, but I stopped taking it immediately after this happened.
1Patient Review
8/28/2019 At 5mg of norvasc, after 2 weeks my bp has slightly decreased BUT, now have shortness of breath, swelling in chest, any exertion causes feeling of dizziness and like I am going to pass out, anxiety, muscle pain, shallow breathing like I can't get enough air. This is one TERRIBLE DRUG.
1Patient Review
8/24/2020 I was on this blood pressure medication for three days before having extremely distressing nightmares, an accelerated heart rate, and lightheadedness to the point of passing out. I stopped taking it immediately and haven't had any issues since then.
1Patient Review
1/5/2020 I would never recommend this drug to anyone. The pain in my knee was unbearable and I became severely depressed within just a few days of taking it.
1Patient Review
7/27/2019 I had to stop taking this medication before I could really judge its effectiveness because the water retention and heel pain became too much to bear.
Patient Q&A Section about norvasc
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking Norvasc?
"headache, swelling (edema) of the ankles or feet, dizziness, lightheadedness, drowsiness, tired feeling, nausea, abdominal or stomach pain."
Answered by AI
What is the best time to take Norvasc?
"It does not matter what time of day you take amlodipine; however, it is best to take it at the same time every day for more even blood levels and therefore effectiveness."
Answered by AI
Is Norvasc a good blood pressure pill?
"Norvasc is an effective treatment for lowering blood pressure, and is often the first option for many people. It can also help with chest pain (angina). Some people may experience swelling of the hands and legs while taking this medication."
Answered by AI
What is Norvasc taken for?
"NORVASC tablets are a prescription medicine used to treat hypertension, angina, and coronary artery disease. NORVASC can be used alone or in combination with other medications to treat these conditions."
Answered by AI