Norpramin

Insomnia, Bulimia Nervosa, Panic Disorder + 7 more
Treatment
1 FDA approval
20 Active Studies for Norpramin

What is Norpramin

DesipramineThe Generic name of this drug
Treatment SummaryDesipramine hydrochloride is a medication used to treat depression. It is a type of tricyclic antidepressant and works by blocking the reuptake of serotonin and norepinephrine, two neurotransmitters involved in mood regulation. Desipramine can also be used to address symptoms of neuropathic pain, agitation, and insomnia. Common side effects include sedation, blurred vision, dry mouth, constipation, and urinary retention. Desipramine has less anticholinergic and sedative side effects than other tricyclic antidepressants.
Norpraminis the brand name
image of different drug pills on a surface
Norpramin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norpramin
Desipramine
1964
122

Approved as Treatment by the FDA

Desipramine, also called Norpramin, is approved by the FDA for 1 uses including Depression .
Depression

Effectiveness

How Norpramin Affects PatientsDesipramine is a type of antidepressant drug that works by blocking the reabsorption of certain chemicals in the brain, such as noradrenaline and serotonin. It is more effective at blocking the reabsorption of noradrenaline compared to other antidepressants. After taking desipramine for a few weeks, it can increase the transmission of serotonin. It usually takes 2-4 weeks to notice the effects of desipramine, but people with more severe depression may see results faster.
How Norpramin works in the bodyDesipramine is a medicine used to treat depression. It works by blocking the reuptake of two neurotransmitters, norepinephrine and serotonin. This means that the brain cells can keep more of these chemicals, which can help improve mood. Desipramine also affects some of the receptors that respond to these neurotransmitters, making them more sensitive. This can further increase the effect of the medication. Desipramine also has a small effect on certain parts of the brain that regulate muscle movement, which can cause some side effects.

When to interrupt dosage

The suggested amount of Norpramin is contingent upon the identified condition, including Irritable Bowel Syndrome (IBS), Neuropathic Pain and Chronic Pain. Dosage also depends on the mode of administration, outlined in the table below.
Condition
Dosage
Administration
Insomnia
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Irritable Bowel Syndrome
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Bulimia Nervosa
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Panic Disorder
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Depression
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Diabetic Neuropathy
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Neuralgia, Postherpetic
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Neuropathic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Anorexia Nervosa
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Chronic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic

Warnings

Norpramin has five contraindications and should not be administered while encountering the conditions found in the following table.Norpramin Contraindications
Condition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Norpramin.
Common Norpramin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Desipramine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Desipramine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Desipramine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Desipramine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Desipramine.
Norpramin Toxicity & Overdose RiskThe toxic dose of desipramine for male mice is 290 mg/kg and for female rats is 320 mg/kg. Taking desipramine can cause sedation and low blood pressure due to its effects on the histamine and alpha-1 receptors. Other side effects may include blurred vision, dry mouth, constipation, urine retention, high or low blood pressure, rapid heartbeat, changes in ECG, heart failure, confusion, impaired memory, manic episodes, nausea, vomiting, abdominal pain, diarrhea, anxiety, insomnia, nervousness, headache, and fatigue.
image of a doctor in a lab doing drug, clinical research

Norpramin Novel Uses: Which Conditions Have a Clinical Trial Featuring Norpramin?

791 active studies are investigating the potential of Norpramin to alleviate Anorexia Nervosa, Irritable Bowel Syndrome (IBS) and Depression.
Condition
Clinical Trials
Trial Phases
Diabetic Neuropathy
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Irritable Bowel Syndrome
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1
Panic Disorder
9 Actively Recruiting
Not Applicable
Anorexia Nervosa
0 Actively Recruiting
Insomnia
1 Actively Recruiting
Not Applicable
Chronic Pain
0 Actively Recruiting
Neuropathic Pain
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Bulimia Nervosa
0 Actively Recruiting
Depression
340 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Neuralgia, Postherpetic
0 Actively Recruiting

Norpramin Reviews: What are patients saying about Norpramin?

5Patient Review
9/9/2012
Norpramin for Depression
I've been taking this for over 20 years, and it's helped me a lot. I was originally diagnosed with Epstein Barr and depression, but this medication has worked well for me. About twice a year I go through a brief period of mild depression, but overall this drug is effective. I tried the generic version to save money, but it wasn't as effective. A few years ago I tried a newer drug on my doctor's recommendation, but I had a bad experience so I went back to Norpramin. The old saying is true: "If it works, don't fix it."
5Patient Review
4/10/2009
Norpramin for Depression
I take 25 mg of this drug every night to help with my Prozac. I notice that I sleep better and feel more rested the next day. It's been working well for me and, since it's a generic, the cost isn't bad either.
5Patient Review
9/26/2009
Norpramin for Depression
I've been taking this treatment for about ten years. I struggled with depression before starting it and it's worked so well that I'll probably take it for the rest of my life.
5Patient Review
9/18/2010
Norpramin for Depression
Out of all the anti-depressants available, this tri-cyclic worked the best for me...It broke through the depression along with Pamalor......I am very thankful for this...
4.7Patient Review
6/13/2012
Norpramin for Neuropathic Pain
Norpramin was highly effective for me in treating the burning sensation I had in my legs for five years. Within a week, the pain was gone and it never came back after six months of being off the medication. The only downside is that it affected my ejaculation.
View All Reviews
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Patient Q&A Section about norpramin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Norpramin prescribed for?

"This medication may have positive effects on your mood, sleep, appetite, and energy level. It may also help you take more interest in daily activities. The medication belongs to a class of drugs known as tricyclic antidepressants. It works by restoring the balance of a certain neurotransmitter (norepinephrine) in the brain."

Answered by AI

Does desipramine cause weight gain?

"Do tricyclic antidepressants like desipramine cause weight gain? Yes, they can. However, some people have lost weight while taking this medication. Talk to your provider if your weight has changed a lot while taking desipramine.Jan 12, 2022"

Answered by AI

Is Norpramin still available?

"Yes, the generic version of Norpramin is called desipramine and is available for purchase."

Answered by AI

What are the side effects of desipramine?

"Side effects may include nausea, drowsiness, weakness or tiredness, nightmares, dry mouth, skin more sensitive to sunlight than usual, changes in appetite or weight, and constipation."

Answered by AI

Clinical Trials for Norpramin

Have you considered Norpramin clinical trials? We made a collection of clinical trials featuring Norpramin, we think they might fit your search criteria.
Have you considered Norpramin clinical trials? We made a collection of clinical trials featuring Norpramin, we think they might fit your search criteria.
Have you considered Norpramin clinical trials? We made a collection of clinical trials featuring Norpramin, we think they might fit your search criteria.
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