Plant-Based Diet With Supplements for Multiple Myeloma
Trial Summary
What is the purpose of this trial?
This trial is testing how a plant-based diet, fish oil supplements, and turmeric supplements affect butyrate levels in the stool. The study involves people with specific blood conditions called MGUS or SMM. Researchers want to see if these dietary changes and supplements can increase butyrate, a substance in the gut that can influence health. Fish oil supplements have been shown to lower plasma triglyceride levels but may increase LDL cholesterol and apolipoprotein B levels.
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, you cannot be enrolled in any other therapeutic investigational study concurrently or up to 180 days before the study starts.
What data supports the idea that Plant-Based Diet With Supplements for Multiple Myeloma is an effective treatment?
The available research shows that healthier dietary patterns, which could include a plant-based diet, are linked to better survival rates in multiple myeloma patients. Specifically, one study found that a healthier diet was associated with a 15-24% lower risk of death from multiple myeloma. Additionally, diets high in fruits and vegetables, like those in a plant-based diet, have been associated with a reduced risk of developing multiple myeloma and its precursor condition. While the research does not directly test the plant-based diet with supplements, it suggests that dietary choices can influence outcomes in multiple myeloma.12345
What safety data exists for a plant-based diet with supplements for multiple myeloma?
The provided research does not directly address the safety of a plant-based diet with supplements specifically for multiple myeloma. However, it highlights the general health benefits and perceptions of whole-foods, plant-based diets (WFPB) and dietary supplements. WFPB diets are associated with improved health outcomes for chronic diseases, but concerns about feasibility and acceptability exist. Dietary supplements are widely used but may contain potentially toxic substances, especially when interacting with drugs. Therefore, while WFPB diets and supplements have potential health benefits, their safety and efficacy for multiple myeloma specifically require further study.678910
Is the Whole Foods Plant-based Diet a promising treatment for multiple myeloma?
Yes, the Whole Foods Plant-based Diet is promising for multiple myeloma. Studies suggest that plant-based diets, which include more fruits, vegetables, and whole grains, may lower the risk of developing multiple myeloma and improve survival rates. These diets can also support a healthier gut, which is linked to better outcomes in multiple myeloma patients.1231112
Research Team
Urvi Shah, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Eligibility Criteria
Adults diagnosed with MGUS or SMM who are interested in a plant-based diet and willing to follow study procedures can join. They must have specific blood protein levels based on their condition type, be able to cook plant-based recipes, and not already be on such a diet. Exclusions include drug use, other clinical trials participation, severe food allergies, heavy alcohol consumption, certain infections needing treatment first.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a plant-based diet, omega-3 and curcumin supplements, or placebo for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Algae omega 3 (Dietary Supplement)
- Placebo supplements (Other)
- Whole Foods Plant-based Diet (Behavioural Intervention)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Plantable
Collaborator
Sabinsa pharmaceuticals
Collaborator
Paula and Rodger Riney Foundation
Collaborator
VeggieDoctor
Collaborator
M and M labs
Collaborator