~57 spots leftby Nov 2026

Plant-Based Diet With Supplements for Multiple Myeloma

Recruiting at 7 trial locations
AL
UA
Urvi A. Shah, MD - MSK Myeloma Specialist
Jun J. Mao, MD, MSCE - MSK Integrative ...
Urvi A. Shah, MD - MSK Myeloma Specialist
Overseen ByUrvi Shah, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Memorial Sloan Kettering Cancer Center
Disqualifiers: Whole foods plant diet, Legume allergy, Severe nut allergies, Concurrent programs, Mental impairment, Other study enrollment, Pregnancy, Positive HBV/HCV/HIV, Electrolyte abnormalities, Heavy drinker, Illicit drug use, others

Trial Summary

What is the purpose of this trial?

This trial is testing how a plant-based diet, fish oil supplements, and turmeric supplements affect butyrate levels in the stool. The study involves people with specific blood conditions called MGUS or SMM. Researchers want to see if these dietary changes and supplements can increase butyrate, a substance in the gut that can influence health. Fish oil supplements have been shown to lower plasma triglyceride levels but may increase LDL cholesterol and apolipoprotein B levels.

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, you cannot be enrolled in any other therapeutic investigational study concurrently or up to 180 days before the study starts.

What data supports the idea that Plant-Based Diet With Supplements for Multiple Myeloma is an effective treatment?

The available research shows that healthier dietary patterns, which could include a plant-based diet, are linked to better survival rates in multiple myeloma patients. Specifically, one study found that a healthier diet was associated with a 15-24% lower risk of death from multiple myeloma. Additionally, diets high in fruits and vegetables, like those in a plant-based diet, have been associated with a reduced risk of developing multiple myeloma and its precursor condition. While the research does not directly test the plant-based diet with supplements, it suggests that dietary choices can influence outcomes in multiple myeloma.12345

What safety data exists for a plant-based diet with supplements for multiple myeloma?

The provided research does not directly address the safety of a plant-based diet with supplements specifically for multiple myeloma. However, it highlights the general health benefits and perceptions of whole-foods, plant-based diets (WFPB) and dietary supplements. WFPB diets are associated with improved health outcomes for chronic diseases, but concerns about feasibility and acceptability exist. Dietary supplements are widely used but may contain potentially toxic substances, especially when interacting with drugs. Therefore, while WFPB diets and supplements have potential health benefits, their safety and efficacy for multiple myeloma specifically require further study.678910

Is the Whole Foods Plant-based Diet a promising treatment for multiple myeloma?

Yes, the Whole Foods Plant-based Diet is promising for multiple myeloma. Studies suggest that plant-based diets, which include more fruits, vegetables, and whole grains, may lower the risk of developing multiple myeloma and improve survival rates. These diets can also support a healthier gut, which is linked to better outcomes in multiple myeloma patients.1231112

Research Team

Urvi A. Shah, MD - MSK Myeloma Specialist

Urvi Shah, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

Adults diagnosed with MGUS or SMM who are interested in a plant-based diet and willing to follow study procedures can join. They must have specific blood protein levels based on their condition type, be able to cook plant-based recipes, and not already be on such a diet. Exclusions include drug use, other clinical trials participation, severe food allergies, heavy alcohol consumption, certain infections needing treatment first.

Inclusion Criteria

Your blood or bone marrow test results show specific abnormal levels related to a condition called MGUS or SMM.
I am 18 years old or older.
This criterion seems to be unrelated to clinical trial exclusion criteria. Could you please provide more details or context for this criterion?
See 5 more

Exclusion Criteria

You currently use illegal drugs like heroin or cocaine (not marijuana).
You are currently pregnant.
I am mentally capable of cooperating with treatment.
See 9 more

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a plant-based diet, omega-3 and curcumin supplements, or placebo for 12 weeks

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Algae omega 3 (Dietary Supplement)
  • Placebo supplements (Other)
  • Whole Foods Plant-based Diet (Behavioural Intervention)
Trial OverviewThe trial is testing the effects of a whole foods plant-based diet supplemented with omega-3 from algae and curcumin versus placebo supplements on butyrate levels in stool over at least 12 weeks for those with MGUS or SMM.
Participant Groups
3Treatment groups
Experimental Treatment
Placebo Group
Group I: SupplementsExperimental Treatment1 Intervention
For 12 weeks on the supplement arm, patients will be given algae omega 3 supplements (QWell pharmaceuticals) and curcumin supplements (Sabinsa pharmaceuticals) twice daily.
Group II: Daily Harvest weeklyExperimental Treatment1 Intervention
For 12 weeks, on the Daily Harvest weekly arm, patients will receive two premade meals per day, for lunch and dinner for 6 days weekly, prepared and shipped by U.S.-based company Daily Harvest weekly.
Group III: PlaceboPlacebo Group1 Intervention
For 12 weeks on the placebo arm, patients will be given placebo supplements twice daily (QWell and Sabinsa pharmaceuticals).

Find a Clinic Near You

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials
1,998
Recruited
602,000+

Plantable

Collaborator

Trials
1
Recruited
150+

Sabinsa pharmaceuticals

Collaborator

Trials
1
Recruited
150+

Paula and Rodger Riney Foundation

Collaborator

Trials
1
Recruited
150+

VeggieDoctor

Collaborator

Trials
1
Recruited
150+

M and M labs

Collaborator

Trials
1
Recruited
150+

Findings from Research

A study of 423 multiple myeloma patients showed that healthier dietary patterns, such as those reflected in the Alternate Healthy Eating Index, are associated with a 15-24% lower risk of MM-specific mortality, suggesting that diet may influence survival outcomes.
Conversely, patients with less healthy dietary habits, indicated by higher scores in the Western dietary pattern, experienced a 16-24% increase in MM-specific mortality, highlighting the potential impact of diet on disease progression.
Prediagnosis dietary pattern and survival in patients with multiple myeloma.Lee, DH., Fung, TT., Tabung, FK., et al.[2022]
In a study of 61 patients with multiple myeloma, those with low carbohydrate intake showed significant improvements in clinical parameters like hemoglobin and albumin compared to those with medium carbohydrate intake, suggesting that diet quality may influence disease outcomes.
Despite the observed effects of diet on clinical parameters, patients' nutrition knowledge did not correlate with their clinical status or nutrient intake, indicating a need for better nutritional education and personalized dietary advice for improving patient health.
High Carbohydrate Diet Is Associated with Severe Clinical Indicators, but Not with Nutrition Knowledge Score in Patients with Multiple Myeloma.Borsi, E., Serban, CL., Potre, C., et al.[2021]
In a study of 5,764 participants, consuming fruit at least three times a week during adolescence was linked to a lower risk of developing monoclonal gammopathy of undetermined significance (MGUS), with an odds ratio of 0.62.
Additionally, higher fruit intake in late life was associated with a significantly reduced risk of progression from MGUS to multiple myeloma (MM), with a hazard ratio of 0.34, suggesting that diet may play a role in both the development and progression of these conditions.
Dietary intake is associated with risk of multiple myeloma and its precursor disease.Thordardottir, M., Lindqvist, EK., Lund, SH., et al.[2019]

References

Prediagnosis dietary pattern and survival in patients with multiple myeloma. [2022]
High Carbohydrate Diet Is Associated with Severe Clinical Indicators, but Not with Nutrition Knowledge Score in Patients with Multiple Myeloma. [2021]
Pre-Diagnosis Dietary Patterns and Risk of Multiple Myeloma in the NIH-AARP Diet and Health Study. [2023]
Dietary intake is associated with risk of multiple myeloma and its precursor disease. [2019]
Diet and risk of multiple myeloma in Connecticut women. [2022]
The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. [2018]
Dietary supplements and functional foods: 2 sides of a coin? [2022]
A Place for Plant-Based Nutrition in US Medical School Curriculum: A Survey-Based Study. [2022]
Development and Application of a Plant-Based Diet Scoring System for Japanese Patients with Inflammatory Bowel Disease. [2019]
10.United Statespubmed.ncbi.nlm.nih.gov
Whole-Foods, Plant-Based Diet Perceptions of Medical Trainees Compared to Their Patients: A Cross-Sectional Pilot Study. [2023]
Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies. [2022]
12.United Statespubmed.ncbi.nlm.nih.gov
Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets. [2023]