Norethindrone Acetate And Ethinyl Estradiol

Endometriosis, Low Testosterone, Osteoporosis + 16 more

Treatment

20 Active Studies for Norethindrone Acetate And Ethinyl Estradiol

What is Norethindrone Acetate And Ethinyl Estradiol

Norethisterone

The Generic name of this drug

Treatment Summary

Norethisterone, also known as norethindrone, is a synthetic hormone that mimics the action of the body’s natural progesterone. It is used to treat irregular menstruation and endometriosis and can also be used as part of a hormone replacement therapy or as an oral contraceptive. It was first created in 1951 in Mexico City and was approved for contraceptive use in 1962.

Necon

is the brand name

image of different drug pills on a surface

Norethindrone Acetate And Ethinyl Estradiol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Necon

Norethisterone

1967

347

Effectiveness

How Norethindrone Acetate And Ethinyl Estradiol Affects Patients

Norethisterone is a synthetic medication taken orally to prevent pregnancy or treat hormone-related conditions such as menopause and endometriosis. It works by altering cervical and endometrial function at the pelvic level, as well as blocking hormones released by the pituitary gland that are involved in the development of eggs. Taking norethisterone, or any other type of combined oral contraceptive, is associated with a small increase in the risk of developing breast cancer. Patients who take this medication should be aware of this risk and perform regular self-exams to check for any masses.

How Norethindrone Acetate And Ethinyl Estradiol works in the body

Norethisterone works by changing the body's hormones to stop pregnancy. It thickens the mucus in the cervix, making it harder for sperm to reach the egg. It also changes the endometrium, making it harder for a fertilized egg to attach. Norethisterone also works on the hypothalamus and anterior pituitary to stop follicle-stimulating and luteinizing hormones from being released, stopping ovulation and corpus luteum development. Lastly, when used as part of hormone replacement therapy, it prevents endometrial hyperplasia and reduces the risk of endometrial cancer.

When to interrupt dosage

The prescribed dosage of Norethindrone Acetate And Ethinyl Estradiol is dependent on the specified situation, such as Atrophic, Fracture and Hormone Replacement Therapy. The quantity of dosage varies, depending on the mode of delivery (e.g. Oral or Tablet) featured in the following table.

Condition

Dosage

Administration

Fracture

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Osteoporosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Atrophic

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

hypoestrogenism

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Hot flashes

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Birth Control

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Therapeutic procedure

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Menopause

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Estrogen Deprivation Symptoms

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Oral Contraceptives

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Low Testosterone

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Osteoporosis, Postmenopausal

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Primary Ovarian Insufficiency

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Hormonal Contraception

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

female castration

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Hormone Replacement Therapy

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Vasomotor System

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Norethindrone Acetate And Ethinyl Estradiol has eight contraindications and should not be used concurrently with the circumstances specified in the following table.

Norethindrone Acetate And Ethinyl Estradiol Contraindications

Condition

Risk Level

Notes

Liver Diseases

Do Not Combine

Thrombophilia

Do Not Combine

Vaginal Hemorrhage

Do Not Combine

Malignant Neoplasms

Do Not Combine

Benign hepatic neoplasm

Do Not Combine

Breast Cancer

Do Not Combine

Thromboembolism

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Norethisterone may interact with Pulse Frequency

There are 20 known major drug interactions with Norethindrone Acetate And Ethinyl Estradiol.

Common Norethindrone Acetate And Ethinyl Estradiol Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Norethisterone.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Norethisterone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.

Clomipramine

Major

The metabolism of Clomipramine can be increased when combined with Norethisterone.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Norethisterone.

Norethindrone Acetate And Ethinyl Estradiol Toxicity & Overdose Risk

The lowest toxic dose of oral contraceptives in mice is 6 g/kg and in human women is 42 mg/kg. Even if a child were to take too many oral contraceptives, there have been no reports of serious health issues. However, overdose symptoms may include nausea and vomiting.

image of a doctor in a lab doing drug, clinical research

Norethindrone Acetate And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norethindrone Acetate And Ethinyl Estradiol?

A total of 160 active clinical trials are investigating the potential of Norethindrone Acetate and Ethinyl Estradiol to provide Birth Control, Hormonal Atrophy and Low Testosterone Therapy.

Condition

Clinical Trials

Trial Phases

Birth Control

21 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2

Oral Contraceptives

1 Actively Recruiting

Not Applicable

Endometriosis

30 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Osteoporosis

28 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 3, Phase 2

Low Testosterone

5 Actively Recruiting

Phase 4, Phase 2, Phase 1

Endometriosis

2 Actively Recruiting

Phase 4, Not Applicable

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3

Estrogen Deprivation Symptoms

0 Actively Recruiting

Osteoporosis, Postmenopausal

0 Actively Recruiting

female castration

0 Actively Recruiting

Atrophic

5 Actively Recruiting

Phase 4, Not Applicable

Hormone Replacement Therapy

0 Actively Recruiting

Hormonal Contraception

0 Actively Recruiting

hypoestrogenism

1 Actively Recruiting

Phase 4

Fracture

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Primary Ovarian Insufficiency

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Menopause

0 Actively Recruiting

Norethindrone Acetate And Ethinyl Estradiol Reviews: What are patients saying about Norethindrone Acetate And Ethinyl Estradiol?

5

Patient Review

5/5/2017

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I haven't experienced any hot flashes, mood swings, or weight gain since beginning this treatment. If anything, I've lost weight!

5

Patient Review

11/7/2011

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I took a break from this treatment for a while, but I really still need it.

5

Patient Review

10/17/2012

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This treatment has completely changed my life for the better. No more hot flashes, no more night sweats, and my husband is thrilled.

5

Patient Review

2/11/2018

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

After being on this medication for a month, I stopped having hot flashes. My cycle started again after three months, which was a bit of a bummer, but other than that I feel great. This has also helped with my hair loss and thinning due to low estrogen levels.

4.3

Patient Review

3/3/2016

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

So far, this treatment has been great! I no longer have hot flashes or night sweats, and my vaginal dryness is much improved. The only downside is that I've gotten one yeast infection--but it's worth it to be free of the hot flashes.

4.3

Patient Review

5/3/2021

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I've been taking this medication for a while now, and it's done wonders for my hot flashes. They stopped almost entirely after only a week of use! I'm also happy to report that I haven't gained any weight since starting the med, which was one of my concerns. The only downside is that I've started having some breakthrough bleeding recently.

4

Patient Review

8/26/2013

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I started this treatment when I was 38 and now I'm 48. It's helped with hot flashes and night sweats, but unfortunately not with the vaginal itching and dryness (for which I have to use an expensive cream). Recently, I realized that the weight issues, bloating, and swelling are NOT normal despite having an overall healthy diet.

4

Patient Review

11/10/2011

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This treatment has been great for my hot flashes. I can sleep through the night now which is amazing. The only downside is that it's given me a bit of gastric trouble and raised my blood pressure and heart rate. I'm going to discuss changing the dosage with my doctor soon.

4

Patient Review

7/2/2022

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

Within one week of taking this medication, my menopausal symptoms (hot flashes and night sweats) disappeared. However, the side effects are tough to deal with; I've been experiencing abdominal pain, nausea, and headaches. I'm going to continue taking it in the hopes that my body will adjust to the medication over time because I don't want to go back to having hot flashes and night sweats.

3.7

Patient Review

9/26/2016

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I've been taking this for just over three weeks now. I haven't had any hot flashes or night sweats, which is amazing, but I have gained four pounds. Not ideal. I go to the gym regularly, so I know it's not from a sedentary lifestyle. Not sure if I need a lower dose or to stop taking it altogether.

3

Patient Review

11/14/2016

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

After three weeks of use, my night sweats have stopped. However, I've unfortunately gained five pounds. It's a tough decision to make: whether to keep using the drug and risk gaining more weight or go without it and deal with the night sweats again.

3

Patient Review

5/28/2016

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This treatment effectively stopped my hot flashes, but I unfortunately gained twenty pounds in just five months. As a result, I had to discontinue use.

3

Patient Review

7/25/2022

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This effectively stopped my hot flashes, but I experienced high anxiety levels as a result, especially in the mornings. I took it for more than a year in the hopes that it would level out, but it didn't.

2.7

Patient Review

2/4/2016

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This medication did help to reduce my hot flashes and elevate my mood, however the weight gain was a significant side effect that I wasn't willing to accept.

2.7

Patient Review

1/30/2015

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

This has helped me with hot flashes, but the weight gain is a big problem.

2.7

Patient Review

8/11/2015

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

The weight gain was really concerning to me...I tried working out and eating healthy, but I would still gain half a pound every week.

2.3

Patient Review

10/15/2013

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

After taking this medication for two weeks, I have found that my depression has actually increased. As a result, I will be discontinuing use of the medication.

1.7

Patient Review

3/30/2014

Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs

I unfortunately developed breast cancer as a result of this treatment. Please be careful.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about norethindrone acetate and ethinyl estradiol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the downside to estradiol norethindrone acetate tablets?

"This medicine comes with risks. It might increase your risk of developing dementia, especially if you're a woman over 65. There's also a chance that it could cause gallbladder disease. If you start experiencing stomach pain, nausea, or vomiting, let your doctor know."

Answered by AI

What are the side effects of norethindrone acetate and ethinyl estradiol tablets?

"These side effects are usually not permanent.

Possible side effects of this medication include nausea, vomiting, headache, bloating, breast tenderness, swelling of the ankles/feet (fluid retention), or weight change. You may also experience vaginal bleeding between periods (spotting) or missed/irregular periods, especially during the first few months of use. These side effects are usually not permanent."

Answered by AI

What is norethindrone acetate and ethinyl estradiol used for?

"The combination of these two hormones also makes the cervical mucus thicker, which makes it more difficult for sperm to reach the uterus and fertilize an egg.

This pill contains a combination of two hormones, ethinyl estradiol and norethindrone, which work together to prevent pregnancy. The pill stops a woman's egg from fully developing each month, making it more difficult for sperm to reach the uterus and fertilize an egg."

Answered by AI

Does norethindrone acetate and ethinyl estradiol cause weight gain?

"Side effects from taking Estrostep can include weight gain from water retention, which is most common in the first one to two months of use."

Answered by AI

Clinical Trials for Norethindrone Acetate And Ethinyl Estradiol

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Alison B Hamilton, PhD MPH

Image of UC San Diego in San Diego, United States.

Epione Device for Bone Conditions

18+
All Sexes
San Diego, CA

The goal of this investigational device exemption is to evaluate the Epione assistance for introducer placement during percutaneous procedures in musculo-skeletic (MSK) structures of the pelvis and the spine in adults. The main question is the determination of the rate of feasible procedures assisted by the Epione device Participants will undergo their procedure(s) as planned by their physician. If they accept to participate to the study, the differences with standard of care will be: * The use of the Epione device to place the introducer(s), instead of freehand placement if they do not participate * Additional CT or CBCT scans during the procedure.

Waitlist Available
Has No Placebo

UC San Diego (+2 Sites)

Sean Tutton, MD

Quantum Surgical

Image of University of Waterloo in Waterloo, Canada.

Virtual Chiropractic Intervention for Spinal Fracture

18+
All Sexes
Waterloo, Canada

This study will determine feasibility of a chiropractor delivered virtual intervention for individuals following osteoporotic vertebral fracture. This pilot trial will have two parallel groups with a 1:1 ratio. Participants will be randomized to: 1) immediate receipt; or 2) waitlist usual care control and delayed receipt of VIVA 10 weeks post-randomization. VIVA is an intervention for people with vertebral fractures that covers four areas: pain management, safe movement, exercise, and nutrition. It includes print and video resources, and a framework for goal setting, selecting exercises, and teaching body mechanics. A chiropractor (DC) completes a virtual assessment and then leads twelve 1:1 virtual sessions (via Zoom) over eight weeks. Sessions start with brief education on a topic (e.g., safe movement, pain management, exercise, nutrition), followed by training and modeling of exercise and safe movement strategies, then goal setting, and action planning. This trial will be considered feasible if a) we recruit 14 people in eight months; b) 80% of participants complete the trial; and c) exercise adherence is 75%.

Recruiting
Has No Placebo

University of Waterloo

Have you considered Norethindrone Acetate And Ethinyl Estradiol clinical trials?

We made a collection of clinical trials featuring Norethindrone Acetate And Ethinyl Estradiol, we think they might fit your search criteria.
Go to Trials
Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada

The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.

Phase 4
Recruiting

Erevna Innovations Inc.

Andreas Nikolis, MD, PhD

Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Ketamine for Pelvic Pain

18 - 89
Female
Cleveland, OH

The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.

Phase 4
Waitlist Available

University Hospitals Cleveland Medical Center

Morgan Cheeks, MD

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