Norethindrone Acetate And Ethinyl Estradiol

Endometriosis, Low Testosterone, Osteoporosis + 16 more
Treatment
20 Active Studies for Norethindrone Acetate And Ethinyl Estradiol

What is Norethindrone Acetate And Ethinyl Estradiol

NorethisteroneThe Generic name of this drug
Treatment SummaryNorethisterone, also known as norethindrone, is a synthetic hormone that mimics the action of the body’s natural progesterone. It is used to treat irregular menstruation and endometriosis and can also be used as part of a hormone replacement therapy or as an oral contraceptive. It was first created in 1951 in Mexico City and was approved for contraceptive use in 1962.
Neconis the brand name
image of different drug pills on a surface
Norethindrone Acetate And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347

Effectiveness

How Norethindrone Acetate And Ethinyl Estradiol Affects PatientsNorethisterone is a synthetic medication taken orally to prevent pregnancy or treat hormone-related conditions such as menopause and endometriosis. It works by altering cervical and endometrial function at the pelvic level, as well as blocking hormones released by the pituitary gland that are involved in the development of eggs. Taking norethisterone, or any other type of combined oral contraceptive, is associated with a small increase in the risk of developing breast cancer. Patients who take this medication should be aware of this risk and perform regular self-exams to check for any masses.
How Norethindrone Acetate And Ethinyl Estradiol works in the bodyNorethisterone works by changing the body's hormones to stop pregnancy. It thickens the mucus in the cervix, making it harder for sperm to reach the egg. It also changes the endometrium, making it harder for a fertilized egg to attach. Norethisterone also works on the hypothalamus and anterior pituitary to stop follicle-stimulating and luteinizing hormones from being released, stopping ovulation and corpus luteum development. Lastly, when used as part of hormone replacement therapy, it prevents endometrial hyperplasia and reduces the risk of endometrial cancer.

When to interrupt dosage

The prescribed dosage of Norethindrone Acetate And Ethinyl Estradiol is dependent on the specified situation, such as Atrophic, Fracture and Hormone Replacement Therapy. The quantity of dosage varies, depending on the mode of delivery (e.g. Oral or Tablet) featured in the following table.
Condition
Dosage
Administration
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Primary Ovarian Insufficiency
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis, Postmenopausal
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Norethindrone Acetate And Ethinyl Estradiol has eight contraindications and should not be used concurrently with the circumstances specified in the following table.Norethindrone Acetate And Ethinyl Estradiol Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
There are 20 known major drug interactions with Norethindrone Acetate And Ethinyl Estradiol.
Common Norethindrone Acetate And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Norethindrone Acetate And Ethinyl Estradiol Toxicity & Overdose RiskThe lowest toxic dose of oral contraceptives in mice is 6 g/kg and in human women is 42 mg/kg. Even if a child were to take too many oral contraceptives, there have been no reports of serious health issues. However, overdose symptoms may include nausea and vomiting.
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Norethindrone Acetate And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norethindrone Acetate And Ethinyl Estradiol?

A total of 160 active clinical trials are investigating the potential of Norethindrone Acetate and Ethinyl Estradiol to provide Birth Control, Hormonal Atrophy and Low Testosterone Therapy.
Condition
Clinical Trials
Trial Phases
Endometriosis
30 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Birth Control
23 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Osteoporosis
34 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Estrogen Deprivation Symptoms
0 Actively Recruiting
female castration
0 Actively Recruiting
Endometriosis
3 Actively Recruiting
Phase 4, Not Applicable
Oral Contraceptives
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Hot flashes
18 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3
Low Testosterone
5 Actively Recruiting
Phase 4, Phase 2, Phase 1
Atrophic
3 Actively Recruiting
Phase 4, Not Applicable
Hormone Replacement Therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Fracture
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Primary Ovarian Insufficiency
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Menopause
0 Actively Recruiting

Norethindrone Acetate And Ethinyl Estradiol Reviews: What are patients saying about Norethindrone Acetate And Ethinyl Estradiol?

5Patient Review
5/5/2017
Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs
I haven't experienced any hot flashes, mood swings, or weight gain since beginning this treatment. If anything, I've lost weight!
5Patient Review
11/7/2011
Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs
I took a break from this treatment for a while, but I really still need it.
5Patient Review
10/17/2012
Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs
This treatment has completely changed my life for the better. No more hot flashes, no more night sweats, and my husband is thrilled.
5Patient Review
2/11/2018
Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs
After being on this medication for a month, I stopped having hot flashes. My cycle started again after three months, which was a bit of a bummer, but other than that I feel great. This has also helped with my hair loss and thinning due to low estrogen levels.
4.3Patient Review
3/3/2016
Norethindrone Acetate And Ethinyl Estradiol for "Change of Life" Signs
So far, this treatment has been great! I no longer have hot flashes or night sweats, and my vaginal dryness is much improved. The only downside is that I've gotten one yeast infection--but it's worth it to be free of the hot flashes.
View All Reviews
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Patient Q&A Section about norethindrone acetate and ethinyl estradiol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the downside to estradiol norethindrone acetate tablets?

"This medicine comes with risks. It might increase your risk of developing dementia, especially if you're a woman over 65. There's also a chance that it could cause gallbladder disease. If you start experiencing stomach pain, nausea, or vomiting, let your doctor know."

Answered by AI

What are the side effects of norethindrone acetate and ethinyl estradiol tablets?

"These side effects are usually not permanent.

Possible side effects of this medication include nausea, vomiting, headache, bloating, breast tenderness, swelling of the ankles/feet (fluid retention), or weight change. You may also experience vaginal bleeding between periods (spotting) or missed/irregular periods, especially during the first few months of use. These side effects are usually not permanent."

Answered by AI

What is norethindrone acetate and ethinyl estradiol used for?

"The combination of these two hormones also makes the cervical mucus thicker, which makes it more difficult for sperm to reach the uterus and fertilize an egg.

This pill contains a combination of two hormones, ethinyl estradiol and norethindrone, which work together to prevent pregnancy. The pill stops a woman's egg from fully developing each month, making it more difficult for sperm to reach the uterus and fertilize an egg."

Answered by AI

Does norethindrone acetate and ethinyl estradiol cause weight gain?

"Side effects from taking Estrostep can include weight gain from water retention, which is most common in the first one to two months of use."

Answered by AI

Clinical Trials for Norethindrone Acetate And Ethinyl Estradiol

Have you considered Norethindrone Acetate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate And Ethinyl Estradiol, we think they might fit your search criteria.
Have you considered Norethindrone Acetate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate And Ethinyl Estradiol, we think they might fit your search criteria.
Have you considered Norethindrone Acetate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate And Ethinyl Estradiol, we think they might fit your search criteria.
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